DESIGN AND EVALUATION OF ANTIUROLITHIATIC EFFERVESCENT HERBAL TABLETS CONTAINING HYDROALCOHOLIC EXTRACT OF BRYOPHYLLUM PINNATUM / تصميم وتقييم الأقراص العشبية الفوارة المضادة لليوروليثيات التي تحتوي على مستخلص مائي كحولي من البريوفيلوم بيناتوم
قطاع الدراسات الصيدلية / الصيدلانيات
تخصص البحث : الصيدلانيات
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ نيلوبال شاما بورا - مؤلف رئيسي
الصيدلانيات
The objective of this study was to prepare and evaluate effervescent tablets containing Bryophyllum pinnatum leaves extract and to assess the in vitro antiurolithiatic activity of these tablets. The leaves of Bryophyllum pinnatum were collected, authenticated, cleaned, dried and extracted using water:ethanol (80:20) as the solvent system. Prior to extraction the crude drug was tested for its macroscopic, microscopic and quantitative standards. The extract was also assessed for its antioxidant potential by determining the DPPH radical, hydroxyl radical, nitric oxide radical and hydrogen peroxide radical scavenging activities; total phenolic and total flavonoid contents. Thereafter, the extract was formulated into an effervescent tablet and characterized for its different evaluation parameters as described previously. The formulated tablets were then assessed for its in vitro antiurolithiatic activity through estimation of the rate of nucleation and aggregation of CaOx crystals. The results were compared with a standard marketed formulation, Cystone®. Statistical analyses were performed using GraphPad Prism software (v6.01, Sept 2012). The antioxidant studies indicated that the Bryophyllum pinnatum extract has high antioxidant potential. The effervescent tablets were prepared by wet granulation method and passed all the evaluation tests, viz. weight variation test, effervescence time, effervescence solution pH, hardness test, thickness of tablets, moisture content and friability. The tablets also demonstrated superior antiurolithiatic activity by reducing the rate of nucleation and aggregation of CaOx crystals.
COMPLICATIONS ASSOCIATED WOUND HEALING IN DIABETIC PATIENTS: DOES NANOTECHNOLOGY HAVE ANY SUPERIOR THERAPEUTIC ADVANTAGES? / المضاعفات المصاحبة لالتئام الجروح لدى مرضى السكري: هل تتمتع تقنية النانو بأي مزايا علاجية فائقة؟
قطاع الدراسات الصيدلية / الصيدلانيات
تخصص البحث : الصيدلانيات
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 26
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ ياسمين أبو زيد - مؤلف رئيسي
الصيدلانيات
Delayed wound healing is one of the main complications facing diabetic patients worldwide. It can be followed by serious consequences such as ulcer, gangrene, amputation unless treated correctly. Four phases of normal wound healing are compromised in diabetic patients due to complex pathophysiology; thus, wounds healing time is prolonged. Consequently, the probability of wounds infections in diabetic patients is higher than non-diabetic patient and it is much higher with immunocompromised diabetic patients. There are several strategies for treatment of diabetic wounds such as; dressings, growth factors, stem cells, antidiabetic drugs, antihypertensive drug, etc. However, some of these strategies are still under investigations to ascertain their safety, while others are clinically non-applicable due to rapid biodegradation. Nanotechnology might be a novel and a promising alternative strategy for diabetic wound healing as nanoparticles could overcome limitations of medical products currently used. Some nanoparticles such as; metal-based nanoparticles (MBNPs) demonstrated an excellent antibacterial activity including resistant strains inhabitant diabetic wound, moreover, some of MBNPs could enhance the healing of wound in diabetic patients via modulating many disturbed issues recorded in four phases of wound healing. This review explores the recent literature in this area, discusses the complications associated diabetic patients with special focus on delayed wound healing, pathophysiology of wound healing in diabetic patients, treatment approved for wound healing and controlling wound infection. In addition, shedding the light on nanotechnology application to improve wound healing, with a special concern devoted to MBNPs including their antibacterial mechanisms and barriers faced to their clinical application.
CYTOTOXIC AND ANTIMICROBIAL EFFECTS OF selectED EGYPTIAN ASTERACEAE SPECIES AS WELL AS GC-MS METABOLITE PROFILING OF SENECIO CRUENTUS LIPOPHILIC FRACTION / التاثيرات السامة للخلايا السرطانية والمضادة للميكروبات لنباتات مصرية مختارة من العائلة النجمية وكذلك معرفة التركيب الكيميائي لمستخلص هكسان السينيسيو كرونتيس بواسطة GC-MS
قطاع الدراسات الصيدلية / العقاقير
تخصص البحث : العقاقير
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ أحمد محمد زاهر - مؤلف رئيسي
العقاقير
The ethanol extracts of three ornamental Asteraceae species; Senecio cruentus DC., Dimorphotheca ecklonis DC. and Arctotis aurantiaca L. were studied for their cytotoxicity against Panc1 and antimicrobial activities against selected microbial strains. Lipophilic fraction of S. cruentus showed the most active cytotoxic extract (IC50 = 7.63±0.46 µg/ml) and was subjected to metabolite profiling by using GC-MS. Seventeen compounds of different categories were identified. The detection of phytol as well as unsaturated fatty acids/esters; cis-vaccenic acid (C18:1), glycidyl oleate (C21:1), 9,12-Octadecadienoic acid (Z,Z)- methyl ester (C19:2), 9,12,15-(Z,Z,Z)- Octadecatrienoic acid, 2,3-dihydroxypropyl ester, (C21:3) and Z,Z-3,15-Octadecadien-1-ol acetate (C20:2) are suggesting its cytotoxicity. The S. cruentus lipophilic fraction exhibited potent cytotoxic activity against A549 (lung) cancer cells (IC50 = 1.919±0.1 µg/ml) through inhibition of cell growth at G1/S stage. All the species displayed moderate antimicrobial activities against certain types of selected strains. The LD50 of S. cruentus ethanol extract was determined as 1.5 g/kg.
ULTRASONIC - ASSISTED EXTRACTION AND MICROENCAPSULATION OF BIOACTIVE COMPOUND from PIGEON PEA SEED / استخلاص وكبسلة دقيقة للمركب النشط بيولوجيا من بذور بازلاء الحمام بواسطة الموجات فوق الصوتية
قطاع الدراسات الصيدلية / العقاقير
تخصص البحث : العقاقير
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 12
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ إرسال موه - مؤلف رئيسي
العقاقير
The global COVID-19 pandemic that began at the end of 2019 has not finished until now. So it is necessary to use local food that contains antioxidant compounds that can improve the immune system. Pigeon pea is one of the indigenous foods that can be utilized as a functional food because it contains bioactive compounds—the objective of this work is to obtain the optimal condition for extracting pigeon pea seed based on total phenol content (TPC) and antioxidant activity and then microencapsulation it. It was demonstrated that the best extraction conditions were 30 min, a temperature of 60 °C, and 90% methanol with TPC 36.0219 mg GAE/30 g dry sample and antioxidant activity 19.6091 mg AAE/30 g dry sample. Pigeon pea seed extract was entrapped by Freeze-drying using gum arabic and maltodextrin as wall material. Microcapsules contained 8.85% water with a solubility of 87.35%. Microcapsules have a color of greenish-yellow chromaticity (GY) and irregular shape with an average size of 23.03 ?m. The best bioactive compounds in pigeon pea seed extract showed the most compounds: mome inositol (42,76%) and isoflavones (13,85%). In addition, there are several other compounds showing bioactivity as antioxidants.
APPLICATION OF ASPERGILLUS ORYZAE ASU44 (OL314732) AND THEIR KOJIC ACID AS PESTICIDES AGAINST COTTON APHID, APHIS GOSSYPII / إستخدام فطرة Aspergillus oryzae ASU44 (OL314732) وحامض الكوجيك المنتج بواسطتها كمبيدات للآفات ضد حشرة مَن القطن
قطاع الدراسات الصيدلية / العقاقير
تخصص البحث : العقاقير
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 20
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ غادة عبدالمنصف محمود - مؤلف رئيسي
العقاقير
Because of their negative effects on the environment, humans, and other organisms, chemical pesticides have been prohibited in many countries. Alternative microbial management is easy-to-implement, effective, and safe for humans and the environment. Fungus-based bio-pesticide products like kojic acid could commercialize as effective alternative chemical pesticides. Aspergillus oryzae ASU44 (OL314732) was isolated from hollyhock rhizosphere and identified using 18S rRNA gene sequencing. The strain showed high ability of kojic acid production especially after optimizing the production using 41-run Box-Behnken statistical design. Maximum kojic acid production was 46.53 g/l (predicted values 46.62 g/l) obtained in run number (23) using Glucose (150, g/l), Yeast extract (5 g/l), KH2PO4 (3 g/l), MgSO4.7H2O (0.5 g/l) and pH (3). The design was effective to applied with coefficient (R2) 0.988, 0.986 (adjusted R2 0.975, 0.972) for kojic acid (g/l) and dry fungal mass formation (g/l). The pathogenicity of the fungus and their kojic acid in addition to standard synthetic kojic acid was investigated to the cotton aphid, Aphis gossypii Glover (Homoptera: Aphididae). All treatments had a considerable impact on aphid mortality. The mortality rate was relative to the duration of exposure and the quantities of bio-pesticides agents. However, data revealed that as concentrations increased, the lethal time values decreased. Aspergillus oryzae ASU44 and its extract containing kojic acid were found effective against A. gossypii. As a result, this research suggests that these agents could be effective in aphid cotton management.
QUALITATIVE PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND WOUND HEALING ACTIVITIES OF PISTACIA PALAESTINA BOISS. EXTRACTS / المسح الكيميائي النباتي النوعي والتحري عن الخصائص المضادة للأكسدة والشافية للجروح في خلاصات نبات البطم الفلسطيني
قطاع الدراسات الصيدلية / العقاقير
تخصص البحث : العقاقير
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 14
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ محمد الشلاش - مؤلف رئيسي
العقاقير
The current work was designed to undertake a qualitative phytochemical screening of various plant parts of Pistacia palaestina, and estimate antioxidant and wound healing activities for therapeutic applications. The qualitative phytochemical screening of the leaf and the fruit of P. palaestina was performed using different chemical tests. The total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity were determined by using Folin-Ciocalteu, aluminum chloride, and DPPH (2,2-Diphenyl-1-picryl hydrazyl) methods, respectively. The extracts with the highest TPC and TFC were examined for their wound healing activity using an incision wound model on rats. The qualitative phytochemical screening revealed the presence of phenols, tannins, flavonoids, carbohydrates, saponins, phytosterols, terpenoids, mucilages, and resins, whereas no coumarins, alkaloids, cardiac glycosides, or anthraquinones were found. TPC and TFC were observed between (144.80 ± 8.81 to 489.79 ± 15.09 mg gallic acid equivalent (GAE)/g extract) and (18.34 ± 1.16 to 36.16 ± 1.05 mg rutin equivalent (RUE)/g extract), respectively. Methanolic extracts of leaves and fruits showed high antioxidant activity with IC50 about 5.16 ± 1.22 and 8.21 ± 1.87 ?g/mL, respectively, which are slightly higher than ascorbic acid (IC50 = 3.52 ± 0.14 ?g/mL). The prepared ointments from methanolic extracts significantly accelerated wound healing compared to a negative control group, as the final time of healing was 8.2 ± 1.30 (fruits), 9.6 ± 1.14 (leaves), 12 ± 1.22 (gentamicin ointment 0.1%) and more than 21 (negative control) days. In conclusion, P. palaestina could be used for the treatment of skin wounds.
THE PHYTOCHEMICAL PROFILE OF MANGIFERA RUFOCOSTATA KOSTERM AND ITS ANTIOXIDANT ACTIVITY / دراسة فيتوكيميائية لنبات مانجيفيرا روفوكوستاتا كوستيرم ونشاطه المضاد للأكسدة
قطاع الدراسات الصيدلية / العقاقير
تخصص البحث : العقاقير
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 7
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ ديني سيتياوان - مؤلف رئيسي
العقاقير
The tandui plant (Mangifera rufocostata Kosterm.) is one of the typical plants of South Kalimantan which belongs to the genus Mangifera. It has the potential as medicine. The local people use boiled water from bark of M. rufocostata to treat diabetes and minor stoke. This study aims to identify compounds and determine the antioxidant activity of leaves and bark ethanol extract M. rufocostata qualitatively and quantitatively. The results of the identification show that ethanol extract of M. rufocostata contains tannins, phenols, flavonoids and saponins. The result of the qualitative antioxidant activity test shows that the ethanol extract of M. rufocostata has an antioksidan activity. The result of quantitative antioxidant acivity test reveals that the leave and bark have IC50 value of 7,614 ppm and 8,254 ppm. Based on this research, it can be concluded that ethanol extract of M. rufocostata from Hulu Sungai Tengah District contains various secondary metabolites such as tannins, phenols, flavonoids, and saponins and have a very strong antioxidant activity
RESIDUAL SOLVENTS ANALYSIS IN METRONIDAZOLE RAW MATERIAL USING HEAD SPACE GAS chrOMATOGRAPHY / تحليل المذيبات المتبقية في مادة ميترونيدازول الخام باستخدام كروماتوجرافيا غاز مساحة الرأس
قطاع الدراسات الصيدلية / الكيمياء التحليلية الصيدلية
تخصص البحث : الكيمياء التحليلية الصيدلية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ مطمور درويشة - مؤلف رئيسي
الكيمياء التحليلية الصيدلية
In pharmaceutical raw material (PRM), the residual solvents (RS) are residual impurities which must be controlled due to their toxicity. In this study, we report the quality control results of residual solvents impurties analysis using head space gas chromatography with flame ionization detector (HS-GC-FID) of six raw materials samples of Metronidazole marketed in Algeria. The GC is equipped with a flame-ionization detector and silica column coated with 1.8 µm layer of phase G43. The carrier gas is nitrogen with a linear velocity of 35 cm/s and a split ratio of 1:5. The column temperature is 40 °C then it rise to 240 °C. The injection temperature is 140 °C and that of detector is 250 °C. 29 organic solvents belongs to classes 1 and 2 were researched whose control is mandatory because of their carcinogenic and intrinsic toxicity, only five solvents were identified in the different samples and the methanol was quantified in M2 sample. All samples collected satisfy the test except M2 sample which contains a slight excess of methanol estimated of 14 ppm. This slight excess show that M2 sample wasn’t well purified and this may be due to the difficulty of solvents complete removal.
APPLICATION OF FAST NON- INVASIVE SOLID STATE ANALYSIS ON COUNTERFEIT TRACING OF PHARMACEUTICAL DRUG EXCIPIENTS / تطبيق تحليل الحالة الصلبة السريع وغير الجراحي على التتبع المزيف لسواغات الأدوية الصيدلانية
قطاع الدراسات الصيدلية / الكيمياء التحليلية الصيدلية
تخصص البحث : الكيمياء التحليلية الصيدلية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ ريم يوسف شاهين - مؤلف رئيسي
الكيمياء التحليلية الصيدلية
Near-infrared (NIR) spectroscopy has long been used for quantitative and qualitative analysis. It offers the advantages of being rapid and non-destructive technique. Pharmaceutical analysis is always concerned with active pharmaceutical ingredients (APIs), while no focus is done on the analysis of excipients used in pharmaceutical dosage forms. In this study, the NIR spectra of most commonly used excipients are presented, the interpretation of such spectra can be used as a reference in counterfeit tracing during pharmaceutical analysis. In this article, twenty two excepients are studied which fall into seven classes: disaccharides [?-lactose anhydrous, ?-lactose monohydrate and sucrose], polysaccharides [corn starch, wheat starch, sodium starch glycolate, maltodextrin, croscarmellose sodium, microcrystalline cellulose, hydroxypropyl cellulose and hypromellose (hydroxypropylmethyl cellulose)], a fatty acid and its salt [stearic acid and magnesium stearate], a carboxylic acid salt [potassium sorbate] inorganic compounds [calcium carbonate, dibasic calcium phosphate, silicon dioxide and talc], an anionic surfactant [sodium lauryl sulphate (sodium dodecyl sulphate)] and unclassified compounds [calcium ascorbate, candelilla wax and polyvinylpyrrolidone]. Counterfeit tracing was applied for samples representing each class of excipients by examination of their NIR spectra followed by comparison with the related spectra of the standards.
STUDY OF RELATED IMPURITIES PROFILE BY HPLC: CASE OF FIVE SAMPLES OF FLUCONAZOLE ACTIVE PHARMACEUTICAL INGREDIENT / دراسة ملف تعريف الشوائب ذات الصلة بواسطة HPLC: حالة خمس عينات من FLUCONAZOLE API
قطاع الدراسات الصيدلية / الكيمياء التحليلية الصيدلية
تخصص البحث : الكيمياء التحليلية الصيدلية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 12
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ مطمور درويشة - مؤلف رئيسي
الكيمياء التحليلية الصيدلية
The main objective of this work was to analysis nine drug related impurities (A-I) by High Performance Liquid chromatography (HPLC) in five samples (F1-F5) of Fluconazole active pharmaceutical ingredient (API), collected from five pharmaceutical industries installed in Algeria. For the organic related-impurities analysis, a liquid chromatography apparatus HPLC-UV device equipped with an automatic injector and UV/Vis detector and a column (C18), deactivated for the bases, post-grafted (5 ?m) and dimensions (w: 0.15 m, ?: 4.6 mm) were used. Each sample of Fluconazole API was processed according to the related substances procedures of the European Pharmacopoeia (EP), 8th edition. The HPLC related-impurities analysis showed that the F1, F3, F4 and F5 samples had an individual content of specified impurities (A, B and C) and unspecified impurities meeting the required standards with a total of all impurities present meeting with the standard. F2 sample had a high content of unspecified impurity 0.126 % compared to the acceptance limit and a total of impurities 0.387 % meeting the standard. This can be explained either by the sample degradation which may be due to poor storage conditions or the batch from which this sample comes wasn’t well purified during the synthesis route
UTILIZATION OF THE STABILITY-INDICATING RP-HPLC METHOD FOR DIETRY SUPPLEMENT CALCIUM OROTATE QUANTIFICATION IN CAPSULE DOSAGE FORM / استخدام طريقة كروماتوجرافيا السوائل ذات الأداء العالى كتحاليل دالة على الثبات لمكملات الحمية الغذائية الكمية لأورتات الكالسيوم فى الكبسولات كشكل صيدلى
قطاع الدراسات الصيدلية / الكيمياء التحليلية الصيدلية
تخصص البحث : الكيمياء التحليلية الصيدلية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 16
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ هيمانت كومار تي - مؤلف رئيسي
الكيمياء التحليلية الصيدلية
A rapid, accurate, and precise HPLC approach for quantifying calcium orotate in capsule dosage form was developed and validated. As optimum conditions for analysis, a C8 column (250 mm x 4.6 mm, 5?) was used as the stationary phase, with a mobile phase of 65:35 v/v acetonitrile and 25 mM potassium dihydrogen phosphate buffer (pH 4.7) at a flow rate 1 ml/min and detected at 254 nm. The method showed a 0.999 correlation and an excellent linear response throughout a concentration range of 15–90 ?g/ml. Retention lasted for 3.186 minutes. Validation of the method done as per the requiremnts of ICH and subjected to oxidation, photolysis, heat, acid, alkali hydrolysis, and water stress. Degradation byproducts did not affect the ability to detect calcium orotate, hence the approach is stability indicating. The approach may be used to determine calcium orotate in pharmaceutical capsule dose form since the findings of the research were within the parameters of ICH standards.
DEVELOPMENT OF RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF NEBIVOLOL HYDROCHLORIDE, VALSARTAN AND HYDROCHLOROTHIAZIDE IN CO-ADMINISTRATED ANTIHYPERTENSIVE AGENTS AND HUMAN PLASMA / تطوير طريقة فصل باستخدام كروماتوغرافيا السائل ذات الأداء العالي لتحديد متزامن لـنيبفولول ، هيدروكلوروثيازيد و فالسارتان في مستحضرات الأدوية الخافضة للضغط التي يتم تناولها معاً و كذلك في البلازما البشرية
قطاع الدراسات الصيدلية / الكيمياء التحليلية الصيدلية
تخصص البحث : الكيمياء التحليلية الصيدلية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 16
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ مريم محمد - مؤلف رئيسي
الكيمياء التحليلية الصيدلية
Reversed phase high performance liquid chromatography combined with photodiode array (HPLC-PDA) detector method was developed for simultaneous determination of two binary antihypertensive combinations; either Nebivolol (NEB) with Hydrochlorothiazide (HCZ) or with Valsartan (VAL) in pharmaceutical formulation and spiked human plasma. The method was successfully applied to separate the three drugs on one chromatogram under the same chromatographic conditions that used for two binary combinations. The separation was established on Xterra C18 column using gradient mobile phase which composed of acidified water of pH = 3.0 (adjusted with 0.1% orthophosphoric acid) and acetonitrile with flow rate of 1.0 mL/min. The drugs were determined at 280 nm. Concentration range of each analyte was shown linearity at 5.0–70.0 ?g/mL for NEB, 8.0–60.0 ?g/mL for HCZ and 5.0-80.0 ?g/mL for VAL. The results of method validation were displayed according to ICH guidelines. The green assessment of the proposed has been carried out using two different tools.
STANDARDIZATION AND GC-MS ANALYSIS OF KERSEN (MUNTINGIA CALABURA L.) FRUIT ETHANOL EXTRACT AS AN HERBAL RAW MATERIAL / التوحيد القياسي وتحليل كروماتوغرافيا الغاز - مطياف الكتلة لمستخلص الإيثانول لثمار الكرز (مونتينجيا كالابورا ل.) كمادة عشبية خام
قطاع الدراسات الصيدلية / الكيمياء التحليلية الصيدلية
تخصص البحث : الكيمياء التحليلية الصيدلية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 15
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ س. نور - مؤلف رئيسي
الكيمياء التحليلية الصيدلية
Kersen (Muntingia calabura) is a plant widely reported to have pharmacological effects so it can be developed as a traditional medicine. This study aims to standardize the ethanol extract of kersen fruit from various locations where it grows in South Sulawesi Province, Indonesia. Standardization-specific parameters were carried out, including organoleptic analysis, phytochemical profiles, water, insoluble ethanol extracts, phenolic content, and total flavonoids. Non-specific parameters include total ash content, acid insoluble ash content, water content, drying shrinkage, specific gravity, and heavy metal contamination content of Pb, Cd, and Cu. The ethanol extract of the kersen fruit was also followed by GC-MS analysis. Specific parameters in the chemical content analysis showed the presence of groups of phenolic compounds, tannins, saponins, alkaloids, steroids, and terpenoids. The water-soluble extract content yielded <2%, and the ethanol-soluble extract content was 14-15.12%; The total phenolic content obtained was 11-12.20% EAG; total flavonoids obtained levels of 3-6.34% EQ. Non-specific parameters indicate that the total ash content is 0.19-0.31%; acid-insoluble ash content of 1.09-1.33%; water content <10%; Drying shrinkage <4%; specific gravity of 1.01-1.07 g/mL; total plate number and mold and yeast numbers obtained the number of colonies <20 colonies/g; and the content of Pb, Cd, and Cu respectively obtained levels of 0 mg/Kg. The results of the GC-MS analysis obtained 36 compounds belonging to the benzoate, phenolic, alkaloid, terpenoid, steroid, and fatty acid ester groups. It can be concluded that the ethanol extract of kersen fruit can be considered a raw material for developing traditional medicine in Indonesia.
CHROMATOGRAPHIC ISOLATION, IDENTIFICATION AND charACTERIZATION OF SOME CHEMICAL CONSTITUENTS OF PETROSELINUM CRISPUM LEAVES AND EVALUATING AS HEPATOPROTECTIVE AGENTS / فصل كروماتوجرافي و تعريف وتوصيف لبعض المركبات الكيميائيه لاوراق نبات بيتروسلينيم كرسبم و تقييمها كعوامل واقيه للكبد
قطاع الدراسات الصيدلية / الكيمياء العضوية الصيدلية
تخصص البحث : الكيمياء العضوية الصيدلية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 13
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ ايمان مرسى - مؤلف رئيسي
الكيمياء العضوية الصيدلية والكيمياء الدوائية
Petroselinum crispum Mill. (family Apiaceae) is widely used as an essential spice due to its health benefits. This study aimed to investigate the constituents of P.crispum aerial parts and evaluate its hepatoprotective activity. Ethyl acetate and n-butanol fractions of P. crispum subjected to different chromatographic separation techniques. The compounds were identified on the basis of spectral data and compared with previously reported data. Also, the methanolic extract and n-butanol fraction were evaluated for in-vivo hepatoprotective activity against carbon tetrachloride (CCl4) induced hepatotoxicity in mice (10 groups; 8 mice/group). All groups intraperitonially injected by CCl4 (0.5mg/kg b.w., i.p.) in single dose at 11th day, the treated groups received (100, 200, 300, 400 mg/kg b.w.) of MeOH extract and BuOH fraction separately for 14 days. The results revealed that seven compounds were isolated from EtOAc and n-BuOH fractions which were identified as ?-sitosterol (1), quercetin (2), isorhmentin (3), apigenin (4), apigenin-7-O-?-D-glucopyranoside (cosmosiin) (5), diosmetin-7-O-?-D-glucopyranoside (6), apigenin 7-O-?- D- apiofuranosyl (1?2)-?- D glucopyranoside (apiin) (7). On other hand, CCl4 – induced hepatotoxicity cleared in severe liver damage, showed elevation of liver enzymes. The MeOH extract and n-BuOH fraction exhibited significant hepatoprotection in improvement liver enzymes, with a propensity to return to near-normal levels. So, P. crispum extracts are promising in-vivo hepatoprotective activity.
SYNTHESIS, charACTERIZATION AND ANTIBACTERIAL EVALUATION OF NOVEL ?- LACTAM AND THIAZOLIDIN-4-ONE DERIVATIVES HAVING THIADIAZINYL RING / التشييد والتوصيف والتقييم المضاد للبكتيريا لمشتقات بيتا - لكتام و الثيازوليدون الجديدة التي تحتوي على حلقة ثياديازينيل
قطاع الدراسات الصيدلية / الكيمياء العضوية الصيدلية
تخصص البحث : الكيمياء العضوية الصيدلية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 14
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ كريشنا سريفاستافا - مؤلف رئيسي
الكيمياء العضوية الصيدلية والكيمياء الدوائية
Since ancient times, several heterocyclic scaffolds have been recognized as possessing a wide spectrum of anti-infectious pharmacological properties. The present work aimed to synthesize and to perform antibacterial screening of some novel heterocyclic derivatives of thiadiazinyl ?-lactam and thiazolidin-4-one. Cyclization of thiosemicarbazide with cyclohexanone and substituted aromatic aldehydes leads to the formation of Schiff bases, which form thiazolidinone derivatives upon reaction with thioglycolic acid in the presence of a catalytic amount of ZnCl2. Lactam derivatives were synthesized by the cyclization of Schiff bases with chloroacetyl chloride in presence of triethyl amine. The synthesized derivatives 2a (MIC 25 µg/ml), and 3f (MIC 25 µg/ml) with 4-OH, 3-OCH3, and o-hydroxy substituents, respectively, exhibit good activity against S. aureus, while compound 2c containing p-nitro substituent was found to be the most active (MIC 12.5 µg/ml) against B. subtilis. In Gram-negative bacterial strains, compound 3b (o-chloro) was extremely potent (MIC 12.5 µg/ml) against P. pneumonia while compound 2d containing the p-hydroxy group shows excellent activity (MIC 12.5 µg/ml) against E.coli.
SECONDARY METABOLITES from THE STEM BARK OF POLYALTHIA STENOPETALA (HOOK. F. & THOMSON) RIDL. AND THEIR ACETYLCHOLINESTERASE ACTIVITY / الأيضات الثانوية من اللحاء الجذعي لـنبات بولي الثيا ستينوبيتالا (هوك. و. وطومسون ريدل) و نشاط أسيتيل كولين استيراز خاصتهم
قطاع الدراسات الصيدلية / الكيمياء العضوية الصيدلية
تخصص البحث : الكيمياء العضوية الصيدلية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 7
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ وان محمد نزل حكيمي وان صالح1 - مؤلف رئيسي
الكيمياء العضوية الصيدلية والكيمياء الدوائية
Plants have always been a common source of medicaments, either in the form of traditional preparations or as pure active principles. Polyalthia belong to the Annonaceae family and are a type of evergreen trees distributed across many tropical and subtropical regions. Polyalthia stenopetala is locally used to treat rheumatic fever and diarrhea. Herein, we report the phytochemical composition and acetylcholinesterase (AChE) inhibitory activity of Polyalthia stenopetala. Fractionation and purification of the stem bark extract of P. stenopetala led to isolation and identification of laurotetanine (1), N-methyllaurotetanine (2), reticuline (3), liriodenine (4), yangambin (5), syringaresinol (6), vanillic acid (7), 4-hydroxybenzoic acid (8), cinnamic acid (9), and syringic acid (10). Structures of these ten compounds were elucidated using different spectral analyses and their comparison with previously reported data. All isolated compounds were found to inhibit AChE (inhibition of 40.2 to 80.6%). Our study highlights the potential of Polyalthia species as phytomedicinal sources.
BIOSYNTHESIS, charACTERIZATION, AND ANTIMICROBIAL ASSESSMENT OF METAL NANOPARTICLES from DRYOPTERIS MANNIANA (HOOK.) C. chr LEAF EXTRACT / التخليق الحيوى و التعرف و التقييم كمضاد للميكروبات لجسيمات نانوية معدنية من مستخلص أوراق نبات دريوبتريس مانيانا (هوك) س. كر
قطاع الدراسات الصيدلية / الكيمياء العضوية الصيدلية
تخصص البحث : الكيمياء العضوية الصيدلية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 14
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ آي. ب. إيجيديك - مؤلف رئيسي
الكيمياء العضوية الصيدلية والكيمياء الدوائية
Background: An integral part of nature is medicinal plants containing natural constituents which are vital to health. Dryopteris manniana (Hook.) C. chr. leaves contain phytochemicals such as polyphenols and flavonoids which serve as an effective reducing agent. Methods: Metallic nanoparticles were synthesized by reducing salts of silver, nickel, manganese, and copper using Dryopteris manniana leaf extracts to form metal nanoparticles represented as AgNPs, NiNPs, MnNPs, and CuNPs respectively. The obtained nanoparticles were then characterized using UV-Visible Spectroscopy, Fourier-transform infrared spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and Energy-dispersive X-ray spectroscopy (EDX). The antimicrobial activities of the nanoparticles were investigated against six microbial strains using the disk diffusion method. Results: The EDX result identified the metal atoms present in the metal nanoparticles formed. The SEM revealed that AgNPs have a diamond-like crystalline, CuNPs have a triangular-like structure, NiNPs have a teardrop-like structure, and MnNPs have a spherical crystalline structure. The results of the antimicrobial experiments showed that the nanoparticles have activity against all the tested bacteria but are less active against some isolated fungi. AgNPs showed zone of inhibitions: S. aureus (10 mm), ?-H. streptococcus (8 mm), and E. coli (12 mm), while CuNPs exhibited 9 mm, 11 mm, and 11 mm against S. aureus, E. coli, and ?-H. streptococcus respectively. Conclusion: This method for green metal nanoparticle synthesis may useful in nanomedicine, environmental, and industrial applications as they possess greater effectiveness and reduced toxicity, however, further investigation will be implemented.
SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING OF DIARYLIMIDAZOLE DERIVATIVES AS NEW POTENTIAL ANTI-INFLAMMATORY AGENTS TARGETING COX-2 ENZYME / تشييد والتقييم البيولوجي والالتحام الجزيئي لمشتقات دياريليميدازول كعوامل محتملة جديدة مضادة للالتهابات تستهدف إنزيم COX-2
قطاع الدراسات الصيدلية / الكيمياء الدوائية
تخصص البحث : الكيمياء الدوائية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 12
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ هند أ. عبد الوهاب - مؤلف رئيسي
الكيمياء العضوية الصيدلية والكيمياء الدوائية
A series of diaryl imidazole derivatives (5a-h) was designed as novel selective COX-2 anti-inflammatory drug candidates. The designed compounds were synthesised, and their structures were characterized by spectroscopic analysis. The anticipated anti-inflammatory activity for the synthesized compounds was assessed by in-vitro cyclooxygenases (COX-1/COX-2) inhibition assay. Most of tested compounds demonstrated moderate COX-2 inhibitory activity and selectivity (IC50 = 0.068 – 0.80 µm, SI = 7.5 - 175) in comparison to indomethacin (IC50 = 0.079 µm, SI = 12.5) and celecoxib (IC50 = 0.046 µm, SI = 315.22). Molecular modelling study of the synthesized compounds into the active site of COX-2 enzyme was performed to rationalize their preferred binding affinity; except for compound 5f, all compounds showed binding with amino acids at the selectivity pocket Additionally, In-silico simulation studies explored the drug drug-likeness parameters of the synthesized compounds, all synthesized compounds exhibited promising physicochemical parameters and pharmacokinetics according to the in-silico simulation results.
3D PRINTING TECHNOLOGY IMPLEMENTATION FOR PERSONALIZED MEDICATION / تطبيقات تقنية الطباعة ثلاثية الأبعاد للأدوية المخصصة
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 15
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ سواتانترا ك. س. كوشواها - مؤلف رئيسي
الصيدلة الإكلينيكية
The unique properties of 3D printing technology, such as additive manufacturing, have been attributed to its growing demands in the pharmaceutical and medical device industries. In recent years, these technical approaches have gained in popularity as a cost-effective way to develop custom dose forms for tissue engineering and molecular diagnostics. A multimodal drug delivery system with faster release characteristics is being developed, which is useful in the case of personalized dose forms, according to an assessment of the existing situation. A review of 3D printing technology used throughout pharmaceutical applications was carried out. There are several kinds of 3D printers, and each one employs a unique technique to interact with different materials in diverse ways. In terms of material and application, the most crucial thing to keep in mind with 3D printing is that there is no one-size-fits-all solution. A light and heat source are sometimes used in 3D printers that employ powder materials to melt or fuse the layers of powder to create the desired shape. When using a 3D CAD (Computer Aided Design) file to make a 3D model or scanning a 3D object with a 3D scanner, the filament is heated by the extruder to form the layer and produce the desired shape
NEED AND SATISFACTION OF HEALTHCARE SPECIALISTS TOWARD THE PERFORMANCE OF CLINICAL PHARMACISTS: A CROSS-SECTIONAL STUDY IN PALESTINE / حاجة ورضا أخصائيي الرعاية الصحية تجاه أداء الصيادلة السريريين: دراسة مقطعية في فلسطين
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 13
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ محمد كامل الهبيل - مؤلف رئيسي
الصيدلة الإكلينيكية
Background: Although the willingness of healthcare specialists is a determining factor in the successful implementation of clinical pharmacy services, there is little information on specialists’ needs and satisfaction with incorporating such a new discipline into Palestinian clinical practice. Hence, this study aimed to determine the need and satisfaction of healthcare specialists toward the performance of clinical pharmacists in Palestine.Methods: A cross-sectional study using a self-administered questionnaire was undertaken between March and May 2022 at a tertiary care pediatric hospital. A total of 175 healthcare specialists (physicians, pharmacists, and nurses) working alongside clinical pharmacists were asked to participate in this survey. T-test and one-way ANOVA were used to examine the association between need and satisfaction with the different variables. Results: Of the total; 167 specialists completed the questionnaire with a response rate of 95.4%. The majority 95.8% of specialists expressed a need to work with clinical pharmacists and 94% of them were satisfied with their positive contribution to healthcare delivery. Significant differences were found between the practitioners’ need and their country of education (p= 0.009) and profession (p= 0. 026). Moreover, male participants (p = 0.001) and those holding a master’s degree (p = 0.002) were significantly satisfied with the performance of clinical pharmacists in the healthcare team. Conclusion: Most healthcare specialists had a positive belief in adopting the performance of clinical pharmacists in direct patient care. Consequently, Palestinian stakeholders should be in place to extrapolate clinical pharmacy workers within various healthcare centers and promote their professional collaboration with other specialists.
ROLE OF NEOADJUVANT CHEMOTHERAPY IN THE CONSERVATIVE MANAGEMENT OF NON-MUSCLE INVASIVE BLADDER CANCER (NMIBC) T1 / دور العلاج الكيميائي المساعد الجديد في العلاج التحفظى لسرطان المثانة الغير مخترق للعضلات
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 10
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ هبة م شيحه - مؤلف رئيسي
الصيدلة الإكلينيكية
Aim:In this study our aim is to evaluate the benefit of neoadjuvant chemotherapy (NAC) in high risk NMIBC in preventing disease recurrence and progression while improving overall survival (OS).Patients and Methods:This prospective study included 33 patients with a pathologically confirmed NMIBC(T1) at the time of Transurethral resection of a bladder tumor (TURBT) with one or more high risk features (HRFs) during the period (2019- 2022),at Assiut University Hospital. All patients received 3 cycles neoadjuvant chemotherapy (cisplatin-gemcitabine) every 3 weeks and assessment of response was done by pelviabdomen Multi slice-CT and cystoscopy then TURBT and kept under follow up every 3 months by cystoscopy in the first 2 years. Results: A complete response (CR) was observed in 82% of the patients and disease progression (DP) to in 18% of the patients. Two year OS rate was 79% and two year disease free rate survival(DFS) was 76%.In Univariate regression t Patients with one risk features were 7 time more in 2 years DFS than patients with ? 2 risk features (OR= 6.90), Patients with no foci of squamous differentiation were 5 time more in 2 years DFS than patients with foci of squamous differentiation (OR= 5.25) and all factors were significant. In a multivariate regression model the significant variable only was Patients with no foci of squamous differentiation(OR= 6.92).Conclusion:NAC seems to have promising results in treatment of patients with one HRF NMIBC and a further investigation needed to determine the role of multimodal therapy in patients with two or more high risk feature NMIBC.
CLINICOPATHOLOGICAL AND PROGNOSTIC SIGNIFICANCE OF PLATELET TO LYMPHOCYTE RATIO IN DIFFUSE LARGE B-CELL LYMPHOMA: A META-ANALYSIS / وان الأهمية الإكلينيكية والتشخيصية لنسبة الصفائح الدموية إلى الخلايا الليمفاوية في سرطان الغدد الليمفاوية B- الخلية الكبيرة المنتشرة: التحليل التلوي
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 14
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ محمد أ. عبد الرحيم - مؤلف رئيسي
الصيدلة الإكلينيكية
Background: Nowadays, there is a significant but variable correlation between the diffuse large B-cell lymphoma (DLBL) and the platelet-lymphocyte ratio (PLR). This meta-analysis will assess this association. Methods: A thorough search was done up until June 2022, and 11 research revealed 2284 patients with DLBL. They discovered a connection between DLBL and the PLR. A fixed or random-effect model was used to construct odds ratios (ORs) with 95% confidence intervals (CIs) and examine the prognostic significance of the PLR on overall survival, progression-free survival, and a variety of clinicopathological characteristics. Results: Poor 5-years overall survival (OR, 0.59; 95% CI, 0.36-0.98, p<0.001), poor 2-years progression-free survival subjects (OR, 0.42; 95% CI, 0.27-0.67, p<0.001), and poor 5-years progression-free survival (OR, 0.50; 95% CI, 0.34-0.72, p<0.001) were all significantly correlated with high the PLR. In a similar manner, a high the PLR was strongly correlated with the presence of B-symptoms (OR, 2.22; 95% CI, 1.69-2.93, p<0.001), a high lactate dehydrogenase level (OR, 2.98; 95% CI, 2.19-4.06, p<0.001), a higher tumour stage (OR, 1.84; 95% CI, 1.08-3.13, p=0.03). Nevertheless, there was no significant correlation between a high the PLR and a high Eastern Cooperative Oncology group performance status ?2 (OR, 1.44; 95% CI, 0.69-3.02, p=0.33), a high bone marrow infiltration (OR, 1.02; 95% CI, 0.60-1.74, p=0.94), a person’s gender (OR, 1.20; 95% CI, 0.93-1.55, p=0.17); age (OR, 0.89; 95% CI, 0.69-1.15, p=0.37); and cell of origin (OR, 1.00; 95% CI, 0.71-1.39, p=0.98). Conclusions: The impact of the PLR on DLBL may be substantial as a technique to enhance prognosis. Patients with DLBL who have a high the PLR may be at an independent risk for having a poor prognosis. To prevent potential problems, we advise keeping track of patients with a high platelet-to-lymphocyte ratio.
AZATHIOPRINE AND BIOLOGICAL TREATMENT GENETIC ASSOCIATION WITH CLINICAL RESPONSE AND TOXICITY IN INFLAMMATORY BOWEL DISEASE PATIENTS / دور تعدد الأشكال الجيني في الآزوثيوبرين والعلاج البيولوجي. الاستجابة السريرية والسمية لدى مرضى التهاب الأمعاء
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 26
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ محمد عبد الرحيم - مؤلف رئيسي
الصيدلة الإكلينيكية
Inflammatory Bowel Disease (IBD) involves a variety of conditions, particularly Crohn’s disease (CD) and ulcerative colitis (UC). IBD is characterized by a chronic inflammatory process of the patient’s gut. This review aims to summarize the pharmacogenetics of biologics approved for IBD and the correlation with azathioprine-metabolizing enzymes and adverse reactions, therefore highlighting a likely relationship between particular polymorphisms and therapeutic response. Therefore, we reviewed and discussed the activities of therapeutic drug monitoring (TDM) protocols that use monoclonal antibodies (mABs) with a particular attention to the integration of other actions aimed to exploit the most effective and safest medications for IBD cases. The pharmacotherapy of IBD (CD and UC) has experienced a great advancement with the advent of mABs which have peculiar pharmacokinetic properties differentiating them from chemical agents, like aminosalicylates, antimetabolites (e.g., azathioprine (AZA), 6-mercaptopurine (6MP)), and methotrexate), and immunosuppressant agents (steroids and cyclosporine). But clinical studies showed that biologicals might have pharmacokinetic variability which can affect the anticipated clinical outcomes, beyond primary resistance phenomena. Thus, TDM protocols are applied to the doses of medications according to the required serum mABs levels. This aims to maximize the favourable effects of mABs and minimize the toxicity. But, the presence of particular genetic polymorphisms in patients might determine a different outcome in response to treatment, indicating the heterogeneity of the effectiveness among IBD cases. Indeed, many reports demonstrated significant associations between polymorphisms and response to biologics. In conclusion, the improvement of TNF-, TNFR and IL-1 pharmacogenetics could be the best approach toward a targeted treatment for IBD.Pre-therapy genotyping has to be integrated with IBD therapeutic guidelines, as it is the most suitable approach to choose the most appropriate biologicals for each case. Also, the addition of pharmacodynamic markers (including serum, cellular, or tissue concentrations of TNF-alpha and IL-8) might boost the predictive performance of models and, eventually, control the disease with a significant improvement in quality of life (QOL).
EVALUATING THE EFFECTS OF PERITONSILLAR INFILTRATION OF BUPIVACAINE AND DEXAMETHASONE ON POST-TONSILLECTOMY PAIN REDUCTION IN KIDS / تقييم آثار تسلل الصفاق للبوبيفاكايين وديكساميثازون على الحد من الألم بعد استئصال اللوزتين لدى الأطفال
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 7
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ محمد شوريد يزدي - مؤلف رئيسي
الصيدلة الإكلينيكية
This study aimed to investigate the effect of percutaneous injection of bupivacaine and dexamethasone on pain relief after pediatric tonsillectomy. This clinical trial study was performed on 68 children undergoing tonsillectomy surgery. The intervention group was given topical dexamethasone and topical bupivacaine to reduce postoperative pain but oral paracetamol was administered at a dose of 15 mg/kg when pain score was > 4 in the control group patient. Postoperative pain was recorded by VAS score at 6, 12 and 24 hrs. In the experiment 51.5% of the subjects were male and 48.5% were female and mean age was 7.5 ± 2.99 years. Mean pain at 6 and 12 hrs after surgery was not significantly different between the intervention and control groups, but at 24 hrs after surgery the mean pain in the intervention group was 1.85 ± 0.85 and in the control group was 2.38 ± 1.18 which was statistically significant. There was no significant correlation between mean age, sex, weight, and duration of surgery with mean pain scores in the intervention group and control group at 6, 12 and 24 hrs after surgery.
GLUTEN CONTENT IN PHARMACEUTICALS MARKETED IN THE GAZA STRIP / تحديد محتوى الغلوتين في المستحضرات الصيدلانية المتداولة في قطاع غزة
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 8
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ مي رمضان - مؤلف رئيسي
الصيدلة الإكلينيكية
Gluten is a wheat protein which could trigger an immune-mediated inflammatory response causing Celiac disease. Pharmaceuticals are possible source of gluten due to excipients like wheat starch. This study examined some pharmaceuticals (non-prescription and prescription type) on gluten and partially hydrolyzed gluten fragments content using sandwich and competitive ELISA techniques, respectively. Partially hydrolyzed gluten fragments were detected in ca. 37% of tested samples (Total: 38). Only 5 samples had gluten concentration above 20 ppm. None of the pharmaceuticals had detectable levels of glutens upon sandwich ELISA application. Oral administration of four dosage forms at recommended doses provided celiacs with a daily gluten intake exceeding the daily tolerance limit. Excipients in patient information leaflet were absent in most cases. The findings confirmed that pharmaceuticals could increase the burdens of celiac patients. Accordingly, regular examination of pharmaceuticals on gluten content is advised. Further studies are recommended that would include a larger sample size, and analytical methods to determine gluten in pharmaceuticals should be developed. Registration agencies in the Gaza Strip should apply updated regulations of excipients.
THE EFFECT OF MELATONIN, METFORMIN AND URSODEOXYCHOLIC ACID ON NON-ALCOHOLIC FATTY LIVER DISEASE: A RANDOMIZED, DOUBLE-BLINDED CONTROLLED TRIAL / تأثير الميلاتونين والميتفورمين وحمض أورسوديوكسيكوليك على مرض الكبد الدهني غير الكحولي: تجربة معشاة مزدوجة التعمية ذات شواهد
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 14
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ فريبرز منصور قناعي - مؤلف رئيسي
الصيدلة الإكلينيكية
Objective: This study was to investigate and compare the effect of melatonin, metformin, and ursodeoxycholic acid (UDCA) on non-alcoholic fatty liver disease(NAFLD). Methods: In this randomized double-blinded clinical trial, 120 patients with NAFLD who had been referred to Gastrointestinal and Liver Diseases Research Center, Rasht, Iran, between September 2015 and January 2016. Patients were randomly assigned to 4 groups. Each group received melatonin, metformin, UDCA, or placebo in addition to a weight loss diet for 3 months. Results: A significant reduction was observed in levels of steatosis, alanine aminotransferase, alkaline phosphatase, body weight, BMI, waist circumstance and triacylglycerol among participants in groups with metformin or melatonin administration. In addition a significant decrease in fasting plasma glucose, and total cholesterol concentration was detected following metformin and UDCA administration, respectively. Conclusions: The present study suggests that the addition of metformin or melatonin to a low-caloric diet may be effective in the treatment of patients with NAFLD.
ASSESSMENT OF PENTOXIFYLLINE EFFECTS ON LIVER STEATOSIS UTILIZING DIXON-BASED MRI TECHNIQUE; RANDOMIZED CONTROLLED STUDY / تقييم تأثيرات البنتوكسيفيلين على تنكس الكبد الدهنى باستخدام تقنية التصوير بالرنين المغناطيسي القائمة على ديكسون. دراسة معشاة ذات شواهد
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 18
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ أسماء السيد - مؤلف رئيسي
الصيدلة الإكلينيكية
Background: Pentoxifylline (PTX) has been proven to reduce hepatic steatosis in animal models; however, data regarding its safety and efficacy in type-2 diabetics (T2D) with nonalcoholic fatty liver disease (NAFLD) are rare. Aim: Determine the effects of PTX in reducing liver fat content (LFC; %) in T2D patients with NAFLD in various disease states. Methods: 187 T2D subjects with NAFLD were randomized to receive either Pentoxifylline 800 mg (PTX group) or standard T2D care only (control group) for 24 weeks. The primary outcomes included changes in LFC (%) as measured by magnetic resonance imaging-derived proton density fat-fraction technique (MRI-PDFF) and the calculation of a fibrosis score (NFS). Results: PTX significantly reduced LFC (%) more than the control group (-8.18 vs. -1.87; P< 0.0001). Only the PTX group significantly reduced the NFS score (-1.16; P<0.0001). The PTX group showed significant LFC changes in liver segments II (-9.77; P< 0.0001), IVb (-9.51; P< 0.0001), and VI (-9.13; P< 0.0001); however, the control group achieved significant LFC changes in liver segments III (-2.57; P= 0.02) and VI (-2.22; P= 0.04). In subgroup analysis, PTX showed comparable efficacy in decreasing LFC in different fibrosis scores, gender, and BMI categories. However, Patients with severe steatosis grade (LFC>22.1%) (-10.55%; P=0.001) and HbA1c levels > 7.5% (-8.75%; P= 0.015) achieved significantly higher LFC reductions than other steatosis grades and HbA1c categories. Conclusion: PTX presented a similar efficacy profile in reducing LFC in different fibrosis scores, genders, and BMI categories, while patients with severe steatosis grade and HbA1c > 7.5% achieved higher LFC reductions.
EVALUATING HOSPITAL PHARMACY PRACTICE: MEDICATION PRESCRIBING, TRANSCRIBING, AND ADMINISTRATION IN TABUK REGION, SAUDI ARABIA / تقييم خدمات الممارسة الصيدلة بالمستشفيات: وصف الأدوية ونسخها وتناولها في منطقة تبوك ، المملكة العربية السعودية
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 10
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ مصطفى علي - مؤلف رئيسي
الصيدلة الإكلينيكية
This study aimed to outline the scope of pharmacy practice activities in managing medication use in hospital settings in Tabuk region, Saudi Arabia. The study used a modified American Society of Health-System Pharmacists (ASHP) national survey related to Saudi Arabia hospitals. The pharmacy directors of the Ministry of Health hospitals in Tabuk region were contacted by email. They received a soft copy of the survey questionnaire and a link to the survey formulated using the online survey platform “Google forms”. The survey comprised checklist items inquiring about the nature of professional pharmacy services offered in hospital pharmacies. The responses of the pharmacy directors were received, exported to an Excel sheet, and then to statistical software for analysis. Ten hospitals participated in the survey. The nature of pharmacists’ services was mostly distributive pharmacists in six (60%) hospitals. Four hospitals (40%) reported a regular evaluation of physician adherence to medication-use policies. Five hospitals (50%) reviewed compliance with clinical practice guidelines. Seven hospitals (70%) had computerized prescriber order entry (CPOE) systems with clinical decision support systems (CDSSs) to handle the medication orders. Automation was not much implemented in medication distribution, where three hospitals (30%) used automated dispensing cabinets, and three hospitals (30%) routinely utilized machine-readable coding to verify doses before dispensing. Six of the approached hospitals (60%) had an IV admixture preparation area. Pharmacists were not much engaged in clinical services. More efforts are needed to implement electronic technologies to improve the safety and efficiency of medication prescribing, transcribing, and administration. Pharmacists should expand their role in medication use review, compounding sterile preparations, optimizing medication administration records (MAR), and participation in patient care units.
EVALUATION OF THE EFFICACY AND TOXICITY OF NEO-ADJUVANT SHORT COURSE RADIATION THERAPY CONCURRENTLY WITH CONTINUOUS INFUSION 5-FLUOROURACIL IN THE MANAGEMENT OF LOCALLY ADVANCED RECTAL CANCER PATIENTS / تقيم الفاعلية و السمية للعلاج الاشعاعى و الكيمائى المصغر ما قبل الجراحة فى علاج اورام المستقيم المتقدمة موضعيا
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 9
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ مريم محسن - مؤلف رئيسي
الصيدلة الإكلينيكية
Purpose: To assess the safety and efficacy of neo-adjuvant short-course radiation therapy (SCRT) concurrently with continuous infusion of 5-fluorouracil (5-FU) in the treatment of locally advanced rectal cancer. Method and material:Patients with cT3-4 or any T with N+ rectal cancer diagnosed by magnetic resonance imaging (MRI) and proved pathologically as adenocarcinoma were eligible to be enrolled in our study. Patients received continuous infusion of 5-FU with dose escalation from 100mg/m2/day up to 200mg/m2/day through 5 days concurrently with a SCRT (5 Gy x 5 fractions), followed by 2 months of neo-adjuvant mFOLFOX, radical surgery with total mesorectal excision (TME) was done for patients with complete clinical (cCR), partial response (PR) or stationary disease (SD) and was follow by 4 months of adjuvant mFOLFOX. Results: Twenty patients were included in the study. All patients completed a SCRT concurrently with 5-FU and the 5-FU dose was safely escalated to 200 mg/m2/d with no dose-limiting toxicity (DLT). Four patients (20%) out of 20 patients showed cCR, 14 patients (7o%) had PR, and 2 patients (10%) had disease progression (PD). Four patients (26.7) out of 15 patients had complete pathological response (pCR), and 11 patients (73.3%) had PR. The most common grade III and ? toxicities according to common terminology criteria of adverse events version 5.0 (CTCAE) were diarrhea and abdominal pain. The most common grade ? and ? toxicities were non-hematological toxicity mainly gastrointestinal.
DISPENSING ANTIBIOTICS WITHOUT PRESCRIPTION IN THE ARAB WORLD: A NARRATIVE REVIEW OF THE PREVALENCE, APPROPRIATENESS, FACILITATORS AND PREVENTIVE INTERVENTIONS / بحث مرجعي لدراسة ظاهرة صرف المضادات الحيوية بدون وصفة طبية في العالم العربي من حيث مدى الانتشار، الجودة، المسببات و استراتيجيات الحد منها
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 08/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 22
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ هلا زكريا إبراهيم الأغا - مؤلف رئيسي
الصيدلة الإكلينيكية
Inappropriate antibiotic-related practices are common worldwide but feature more strongly in developing countries. An example of such practices is dispensing antibiotics without prescription [DAwP] in community pharmacies, despite being illegal in most countries around the globe. The aim of this review is to discuss in-depth all aspects related to the practice of DAwP in Arab countries. We searched SCOPUS, PubMed and Google Scholar for articles involving studies addressing the practice of DAwP, conducted in any Arab country, and published from 2000 to 2022. We found that DAwP is very common with extremely high prevalence rates that differ according to methodologies used in those studies. Malpractices associated with DAwP include poor information-gathering before dispensing, poor counseling, inappropriate choice of the antibiotic, recommending antibiotics when they are not indicated, wrong duration and wrong dosing. Common factors shown to contribute to this practice include lax enforcement of regulations, misconceptions about antibiotics by the public, accessibility of community pharmacies, trustability of pharmacists, and the business orientation of pharmacies. Enforcement of regulations, increasing the competency of pharmacists by enhancing undergraduate pharmacy plans and establishing well-planned continuing education programs, reframing regulations to account for the expanding role of competent pharmacists, and increasing the awareness of the public towards antibiotics may limit DAwP and other antibiotic-related inappropriate practices.
ASSOCIATION BETWEEN ANTIBIOTIC RESISTANCE, BIOFILM FORMATION AND LASB GENE IN PSEUDOMONAS AERUGINOSA ISOLATED from DIFFERENT CLINICAL SPECIMENS / الارتباط بين مقاومة المضادات الحيوية وتكوين الأغشية الحيوية وجين lasB في Pseudomonas aeruginosa المعزولة من عينات سريرية مختلفة
قطاع الدراسات الصيدلية / الميكروبيولوجيا والمناعة
تخصص البحث : الميكروبيولوجيا والمناعة
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ شيماء محمد غانم سليمان - مؤلف رئيسي
الميكروبيولوجيا والمناعة
A microorganism’s capacity to form a biofilm is seen as a sign of a clinically significant infection. Pseudomonas aeruginosa infections are challenging to treat since the majority of isolates have high levels of innate resistance to numerous antibiotics and a propensity to develop biofilms. A total of 350 specimens were collected from patients. 125 isolates of P. aeruginosa were recovered from different clinical samples. The antibiotic susceptibility of these isolates against Ciprofloxacin, Amikacin, cefepime, Norfloxacin, imipenem, Genamicin, Tobramycin, Aztreonam, Piperacillin-tazobactam and Colistin was determined using disk diffusion method. The TCP technique assay was chosen to identify the development of biofilm. Elastase gene detection was carried out using polymerase chain reaction (PCR) (lasB). The antibiotics against which there was the greatest resistance were cefepime (92.8%) and ciprofloxacin (67.2%). TCP technique identified 15 as weak or non-biofilm producers, 32 as moderate, and 78 as robust producers of biofilm. In 89.6% of P. aeruginosa isolates, LasB was found. P. aeruginosa’s pattern of antibiotic resistance was more prevalent in biofilm producers than in non-producers. We come to the conclusion that P. aeruginosa biofilm development and drug resistance have a positive association.
IN- VITRO EVALUATION OF NANOCURCUMIN AGAINST MULTI-DRUG RESISTANT BACTERIA / التقييم المختبري لمادة النانو كوركومين ضد البكتيريا المقاومة للأدوية المتعددة
قطاع الدراسات الصيدلية / الميكروبيولوجيا والمناعة
تخصص البحث : الميكروبيولوجيا والمناعة
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 16
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ نهى محمد صفوت إبراهيم عبدالعظيم - مؤلف رئيسي
الميكروبيولوجيا والمناعة
A natural substance called curcumin, derived from the Curcuma longa plant, is frequently used to fight both gram-positive and gram-negative bacteria.It is poorly soluble in water so it has low bioavailability. The aim of this work was to develop effective nanocurcumin formulation to enhance its water solubility and antibacterial activity against four types of multidrug resistant strains. Nanocurcumin was formulated with different combined stabilizers employing antisolvent nanoprecipitation approach and then evaluated in terms of particle size, zetapotential and transmission electron microscopy. The optimized nanocurcumin formulation containing and Polyvinylpyrrolidone K30 (PVP) and Polyethylene glycol 6000(PEG6000) was selected for the In-vitro antibacterial studies against Staphylococcus aureus ATCC® 43300™*, Escherichia coli ATCC® 8739™*, Pseudomonas aeruginosa ATCC® 27853™* and Klebsiella pneumoniae ATCC® 33495™* compared with free curcumin. The prepared nanocurcumin formulation showed mean particle size of 272.15 ± 34.5 nm and polydispersity index (PDI) of 0.423 and high drug content percent ((95.5 ± 1.5 %). The in-vitro antibacterial studies exhibited that the minimum inhibitory concentration (MICs) of free curcumin are 5011, 2511, 10000 and 10000 µg/ml against Staphylococcus aureus ATCC® 43300™*, Escherichia coli ATCC® 8739™*, Pseudomonas aeruginosa ATCC® 27853™* and Klebsiella pneumoniae ATCC® 33495™*, respectively while the MICs of nanocurcumin are 128.8, 549.5, 67.60 and 312.2 µg/ml against Staphylococcus aureus ATCC® 43300™*, Escherichia coli ATCC® 8739™*, Pseudomonas aeruginosa ATCC® 27853™* and Klebsiella pneumoniae ATCC® 33495™*, respectively. It showed highly reduced growth rate of tested strains. Curcumin in nanosized form has remarkable antibacterial activity against Staphylococcus aureus ATCC® 43300™*, Escherichia coli ATCC® 8739™*, Pseudomonas aeruginosa ATCC® 27853™* and Klebsiella pneumoniae ATCC® (MDRO) compared with free curcumin.
THERAPEUTIC PHARMACOLOGICAL PROPERTIES OF CITRULLUS COLOCYNTHIS FRUIT PULPS METHANOLIC CRUDE EXTRACT AGAINST POTASSIUM OXONATE-INDUCED HYPERURICEMIC GOUT RAT MODEL / الخصائص الدوائية العلاجية للمستخلص الميثانولي الخام للب فاكهة نبات الحنظل ضد أكسونات البوتاسيوم المستخدمة في أستحداث النقرس تجريبيا في ذكور الجرذان
قطاع الدراسات الصيدلية / الكيمياء الحيوية
تخصص البحث : الكيمياء الحيوية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 15
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ هبة م. القاضى - مؤلف رئيسي
الكيمياء الحيوية
This study was carried out to study the anti-hyperuricemic and antioxidant properties of C. colocynthis fruit pulps methanolic crude extract. The intra-peritoneal injection with 250 mg/kg/day potassium oxonate (PO) was used to develop hyperuricemic gout rat model. Our results reported that C. colocynthis pulps oral administration introduced potent hypouricemic and antioxidant properties against hyperuricemic gout rat model. The oral administration with C. colocynthis extract greatly alleviated the levels of ankle joint swelling rates (%), serum uric acid, xanthine oxidase (XOD), and thiobarbituric acid reactive substances (TBARS/MDA) as well as reduced the fold of differences of the renal mRNA URAT1 and mRNA GLUT9 urate re-absorption transports. Furthermore, C. colocynthis extract highly increased the levels and activities of serum total proteins content, glutathione peroxidase (GSHPx), and superoxide dismutase (SOD) enzymes. Moreover, Cc pulps extract greatly improved and reduced damage, inflammation and cytotoxicity in the liver and ankle joint specimens. Finally, C. colocynthis fruit pulps greatly introduced powerful therapeutic properties to improve the harmful hyperuricemia features compared to the allopurinol (Allo) administration.
INVESTIGATION OF THE PREVALENCE OF CANDIDURIA IN PATIENTS WITH HEMATOLOGIC MALIGNANCIES IN HOMS – SYRIA / تحري انتشار بيلة المبيضات عند مرضى الخباثات الدموية في حمص – سورية رفاه
قطاع الدراسات الصيدلية / الكيمياء الحيوية
تخصص البحث : الكيمياء الحيوية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 8
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ رفاه العلي - مؤلف رئيسي
الكيمياء الحيوية
The aim of this study was to investigate the incidence of candiduria in patients with hematologic malignancies, and identity its causative agents. The study included 100 patients with one of the following diseases: Acute myeloid leukemia (AML), chronic myeloid leukemia (CML), Acute lymphoid leukemia (ALL), chronic lymphoid leukemia (CLL), Multiple myeloma (MM), Hodgkin’s lymphoma (HL) and Non-Hodgkin’s lymphoma (NHL), who were admitted to the Hematology Department in some hospitals in Homs-Syria between December 2020 to September 2021. Candida species were identified by colony color on chrOMagar candida, germ tube production and micro-morphology on cornmeal agar. Among the 100 patients, 13 (13%) were positive for candiduria. C. albicans was the most common cause of candiduria (61.5%), followed by C. tropicalis and C. krusei (15.4%, respectively) and C. dubliniensis (7.7%). According to the results of the statistical analysis, candiduria was found to correlate significantly with female gender, previous exposure to a urinary catheter, acute myeloid leukemia (AML) and severe neutropenia (<500 cells/mm3).
ISCHEMIA MODIFIED ALBUMIN (IMA): A NOVEL BIOMARKER FOR THE DIAGNOSIS OF ACUTE CORONARY SYNDROME / تقييم دور الألبومين المعدّل بنقص التّروية (IMA) في تشخيص الحوادث الإقفاريّة القلبيّة لدى مرضى الألم الصدري الحاد
قطاع الدراسات الصيدلية / الكيمياء الحيوية
تخصص البحث : الكيمياء الحيوية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 9
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ علا أبو صالح - مؤلف رئيسي
الكيمياء الحيوية
Due to the high mortality rate related to Acute Coronary Syndrome (ACS), early detection is critical. In the emergency room, ischemia modified albumin (IMA) has been proposed as a helpful indicator for the diagnosis of ACS. In this study, we aimed to investigate the role of IMA for its potential in the early diagnosis of ACS in patients experiencing sudden and severe chest pain, and the influence of some variables (gender, age, hypertension, diabetes, hypertriglyceridemia, hypercholesterolemia and smoking) on its level in ACS patients. A total of 127 patients with acute chest pain were included in the study. Patients were divided into three groups: those with acute myocardial infarction (N=45), unstable angina (N=52), and non-ischemic chest pain (NICP) (N=30). Patients with ACS had a higher level of IMA compared to those with NICP. To achieve the best sensitivity (86.5%) and specificity (76.7%), the cutoff for IMA was determined to be 71.3 u/ml. Based on our results, IMA is a sensitive marker for the early diagnosis of ACS in patients presenting with symptoms of acute chest pain.
OBESITY IS ASSOCIATED WITH AUTOPHAGY DYSREGULATION IN EGYPTIAN WOMEN / مصاحبة السمنة لاضطراب الالتهام الذاتي عند النساء المصريات
قطاع الدراسات الصيدلية / الكيمياء الحيوية
تخصص البحث : الكيمياء الحيوية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 14
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ عبد الرحمن عبد القوي - مؤلف رئيسي
الكيمياء الحيوية
Background: Obesity causes a reduced life quality and economic burden to Egyptians. Therefore, it is of utmost importance to investigate its risk factors to establish potential preventive strategies for it and its future complications. Obesity and its associated stress insults can often interfere with the autophagic process through various mechanisms, which can result in further aggravation of obesity-related metabolic pathologies. This case control study aimed at investigating autophagy dysregulation in Egyptian obese women. Methods: This study comprised 85 women that were classified into 5 groups (17 persons each):1- healthy, 2-overweight, 3-moderate obese, 4-severe obese and 5-morbid obese group. The expression of autophagy related gene (ATG5) was estimated by qRT-PCR, whereas, the serum activity of P70S6 kinase was assayed by ELISA. Results: The data revealed elevated mRNA expression levels of ATG5 with a significantly high serum P70s 6 kinase-1 in a stepwise fashion in obese subgroups. Conclusion: The present study demonstrated increased levels of both autophagy parameters in obese women that mean autophagy dysregulation. ROC curve analysis showed that p70S6 kinase-1 is a useful biomarker for both diagnosis and prognosis of obese subgroups. On the other hand, ATG5 was able to discriminate between the severe and moderate obese women. These data may represent a possible protective value for obese women, in addition to establishing potential strategies for autophagy inhibition in obesity and in turn, alleviation of its future complications.
THE IMPACT OF EPITHELIAL TO MESENCHYMAL TRANSITION IN KIDNEY FIBROSIS / تأثير التحول الطلائي الوسيط في تليف الكلى
قطاع الدراسات الصيدلية / الكيمياء الحيوية
تخصص البحث : الكيمياء الحيوية
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 9
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ اوليفيا نادى بشاى - مؤلف رئيسي
الكيمياء الحيوية
Abstract: Fibrosis is a pathological condition attributed to an inappropriate deposition of extracellular matrix that promotes scarring and dysfunction of the implicated organ or tissue. Moreover, fibrosis encompasses an enormous range of organs and tissues, each with a distinct molecular basis. Yet, two factors are discussed: the critical function of transforming growth factor-beta (TGF-?) and the participation of the inflammatory cascade, which is required to initiate fibrotic destruction. Epithelial to mesenchymal transition (EMT), the most prevalent cellular program underlying fibrosis, is regulated by TGF-?, as well as other cytokines. EMT has been widely investigated, although it has not yet been adequately examined as a potential treatment option for fibrosis. A better knowledge of the linkages between fibrosis and EMT may provide an option for the establishment of a highly useful anti-fibrotic treatment. Thus, we provide a general overview of EMT; summarize the significance of TGF-?/Smad signaling cascade in EMT induction, the correlation between both EMT and renal fibrosis and the promising treatment strategies targeting fibrosis induced by EMT.
SHORT-TERM EFFECTS OF THE ANTI-ASTHMATIC DRUG, MONTELUKAST, IN FEMALE RATS / الآثار قصيرة المدى للدواء المضاد للربو ، مونتيلوكاست ، في إناث الجرذان
قطاع الدراسات الصيدلية / علم الأدوية والسموم
تخصص البحث : علم الأدوية والسموم
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 10
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ رواء سالم المياحى - مؤلف رئيسي
علم الأدوية والسموم
Asthma is a chronic disease affecting more than 300 million people worldwide. Rising asthma rates have fuelled a demand for more effort to focus on the possible effects of anti-asthma therapies. Montelukast, a leukotriene receptor antagonist was shown to be an essential mediator of asthma. It has a dual mechanism of action, acting as a bronchodilator and anti-inflammatory. However, such therapy is associated with harmful effects. This study aimed to determine the short term effects following montelukast treatment. A total of twenty female rats were assigned into two equal groups. The control group received vehicle 0.2 ml of saline solution (0.9%), while the treated group received 10 mg/kg/day of montelukast diluted in saline solution 0.9% for five consecutive days. The haematological, biochemical and histopathological analyses were studied. There were no significant differences in haematological analysis and liver enzymes compared with control group. However, there were significant reductions in the levels of total cholesterol, triglyceride and high density lipoprotein compared with control group. Also, several histopathological alterations in rat liver tissues and kidney following montelukast treatment were observed. In conclusion, montelukast has harmful effects even after short treatment periods.
DEPRESSION-LIKE EFFECTS OF LEVETIRACETAM WAS HALTED BY PRETREATMENT WITH N-METHYL-D-ASPARTATE RECEPTOR (NMDAR) BLOCKERS IN MICE / إيقاف التأثيرات المشابهة للاكتئاب لدواء ليفيتيراسيتام عن طريق المعالجة المسبقة بمضادات مستقبلات الجلوتامات ن-مثيل-د-أسبارتات (NMDA) فى الفئران آزاده
قطاع الدراسات الصيدلية / علم الأدوية والسموم
تخصص البحث : علم الأدوية والسموم
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ مسريبور - مؤلف رئيسي
علم الأدوية والسموم
N-methyl-D-aspartate receptor (NMDAR) stimulation might be responsible for levetiracetam -(Lev) induced depression. The aim of our study is to evaluate the effect of noncompetitive NMDAR blockers, dextromethorphan (Dxt) and dizocilpine (MK801), on Lev- induced depression in mice. Male NMRI mice were daily injected with Lev for 14 days. Pretreatments with Dxt, or MK801 were performed 30 min prior to Lev administration. The locomotor test and the forced swimming test (FST) and the novelty suppressed feeding test (NSFT) were performed. Following Dxt or MK801 pretreatment immobility time during FST was lower than Lev alone. There was no change in the locomotor activity. During NSFT, Lev increased latency, and decreased food intake; while, pretreatment with Dxt or MK801 reversed these effects. To our knowledge this is the first study showing that NMDAR blockers prevented the depressive-like behavior induced by Lev in mice. And proved that, at least in part activation of NMDAR is responsible for Lev induced depression, that warrants further research.
NEUROPROTECTIVE EFFECTS OF PHYLLANTUS DEBILIS ON RAT’S HIPPOCAMPUS / التأثيرات الوقائية العصبية ل فيلانتم ديبيليس على الحصين فى الجرذان
قطاع الدراسات الصيدلية / علم الأدوية والسموم
تخصص البحث : علم الأدوية والسموم
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 7
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ ماريا إيماكولاتا إيو - مؤلف رئيسي
علم الأدوية والسموم
Phyllanthus debilis has the potential as an antioxidant and anti-inflammatory, suitable for application in neurodegenerative disorders such as cognitive impairment. This study aimed to examine the effect of P. debilis dichloromethane extract as a neuroprotector in rats treated with electroconvulsive shock (ECS). The rats were given the test substances for 20 days p.o, and ECS induction was held from day 15 to day 19. The Morris water maze (MWM) test determined the cognitive function, while hippocampus homogenates were used for biochemical studies. P. debilis showed the ability to reduce cognitive impairment in ECS-induced rats. The biochemical tests on the rat hippocampus showed a significant increase in catalase (CAT) activity and lipid peroxidase inhibition. The results aligned with anti-inflammatory activity, where TNF-? concentration showed significantly lower results than the ECS control. Overall results demonstrated the ability of P. debilis as a neuroprotective agent through the reduction of oxidative stress and inflammation.
CO-TREATMENT WITH CRANBERRY AND VITAMIN-C AMELIORATES THE HEPATO-RENAL TOXICITIES INDUCED BY PHENOBARBITAL IN WISTAR RATS / العلاج بكل من التوت البري و فيتامين سي يقلل من السمية الكبدية والكلوية الناتجة عن حقن الفينوباربتال في الجرذان المعملية
قطاع الدراسات الصيدلية / علم الأدوية والسموم
تخصص البحث : علم الأدوية والسموم
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 14
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ صبري علي النجار - مؤلف رئيسي
علم الأدوية والسموم
Although phenobarbital (PB) is used to treat epilepsy, its long-term treatment leads to liver and kidney dysfunctions. Natural products, however, can provide essential resources to alleviate hepato-renal toxicities due to their antioxidant’s properties. This study evaluated the impact of cranberries (CB) and Vitamin-C (Vit-C) on hepato-renal toxicities induced by PB in rats. Forty male Wistar rats were allocated into five groups (N= 8) as follows: group 1 (Gp1) was served as a negative control. Gp2 had administered with PB (160 mg/kg), orally for a month. Gp3 and Gp4 had administered with PB as in Gp2, then administered with CB (500 mg/kg) and Vit-C (27 mg/kg), respectively for a month. Gp5 had administered with PB, then administered with a combination of CB and Vit-C as in Gp3 and Gp4. Liver transaminases, albumin, total protein, creatinine, urea, total lipids, cholesterol, as well as catalase (CAT), super oxide dismutase (SOD), glutathione reduced (GSH) and malondialdehyde (MDA) were assessed. The liver and kidney histopathological alterations were examined. The treatment with PB decreased the percentage of the body weight changes, impaired the liver and kidney functions, increased the levels of total lipids, cholesterol, MDA levels, decreased the SOD, CAT activities, and changed the histological architectures of both kidney and liver. Treatment with CB or Vit-C ameliorates the adverse effects that were induced by PB, however, PB-injected rats that were co-treated with CB/Vit-C showed the highest therapeutic effects. Collectively, co-treatment with CB and Vit-C mitigated hepato-renal toxicities induced by PB-treatment in rats.
SHORT AND LONG TERM CARDIOTOXICITY OF SOFOSBUVIR AND DACLATASVIR ASSOCIATED WITH LIPID PROFILE ABNORMALITIES / السمية القلبية لعقارى سوفوسبوفير وداكلاتاسفير و الناتجة عن خلل في مستويات الدهون على المدى الزمنى القصير والطويل
قطاع الدراسات الصيدلية / علم الأدوية والسموم
تخصص البحث : علم الأدوية والسموم
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 13
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ شيرين زكريا - مؤلف رئيسي
علم الأدوية والسموم
Background: Direct-acting antivirals (DAA) are relatively a new group of drugs. Different studies reported disturbances in lipid metabolism among HCV patients treated with DAA combinations Objective: This study tries to evaluate the short and long term effects of DDA on lipid profile, cardiac enzymes and oxidative stress, as well as, to determine if these effects are disease-related or drug-dependent. Methods: Male Wistar rats were treated with sofosbuvir with or without daclatasvir for four consecutive weeks. Five samples were collected at day 0 (baseline point), another ten samples were obtained after four weeks (end of treatment point) and finally, after six months of treatment, the last ten animals were assigned for follow up point. AST, ALT, lipid profile, serum creatine kinase and troponin were assessed colorimetrically. Moreover, liver tissue content of malondialdehyde was assessed. Results: Results revealed that, at the end of drug therapy period, sofosbuvir whether alone or combined with daclatasvir caused significant increase in total cholesterol, LDL and triglyceride compared to baseline data. These effects were persistent for 20 weeks after the end of treatments. This increase in lipid profile was also correlated with a significant deterioration of cardiac markers such as troponin and creatine kinase –MB and increased oxidative stress. Conclusion: Sofosbuvir and/or daclatasvir elevate lipid profile and cardiac enzymes. These changes are due to the effects of direct acting antiviral agents and independent of hepatitis C virus infection. Consequently, Lipid profile and cardiovascular markers should be monitored during and after drug cessation.
LETROZOLE ATTENUATES CARDIOMETABOLIC RISK IN PLASMODIUM BERGHEI-INFECTED MICE / عقار ليتروزول يخفف من مخاطر التمثيل الغذائي القلبي في الفئران المصابة بالبلازموديوم بيرغي
قطاع الدراسات الصيدلية / علم الأدوية والسموم
تخصص البحث : علم الأدوية والسموم
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 14
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ آدم عليتان عبد الكريم - مؤلف رئيسي
علم الأدوية والسموم
Malaria is associated with cardiometabolic disorders, promoting the risk of cardiovascular disease (CVD). We recently demonstrated letrozole’s cardioprotective effects in fructose-exposed male rats. Hence, in this study, we investigated the effect of a low-dose letrozole against cardiometabolic risk in Plasmodium berghei-infected female mice. Twenty female mice were randomly grouped into four (n=5/group): uninfected, infected, letrozole (0.24 mg/kg, p.o/day, without infection), and infected + letrozole. Weekly percentage parasitaemia was recorded. At the end of the 21-day exposure, blood and liver were collected and processed for biochemical analyses. P. berghei infection decreased serum estradiol level after 21-day infection and increased serum and liver levels of malondialdehyde, very low-density lipoprotein cholesterol, triglycerides, and triglycerides/high-density lipoprotein cholesterol (TG/HDL-c) index. Similarly, P. berghei elevated serum uric acid and hepatic total cholesterol levels. Meanwhile, the administered dose of letrozole did not significantly affect serum estradiol but lowered lipid peroxidation, attenuated lipid alterations, and reduced serum uric acid level. We reveal that P. berghei-infection lowered serum estradiol and promoted cardiometabolic risk in female mice, while letrozole lowered parasitaemia and mitigated the associated cardiometabolic risk. Thus, this study is suggestive of letrozole’s potential as an adjuvant therapy for improved management of malaria-induced cardiometabolic complications. Further study is recommended to investigate the anti-malaria potency of letrozole, independent of gender.
RECENT APPROACHES FOR SODIUM-GLUCOSE CO-TRANSPORTER 2 INHIBITORS IN THE MANAGEMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE / الأساليب الحديثة لمثبطات النواقل المشتركة للصوديوم والجلوكوز من النوع الثاني فى السيطرة على مرض الكبد الدهنى غير الكحولى
قطاع الدراسات الصيدلية / علم الأدوية والسموم
تخصص البحث : علم الأدوية والسموم
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 17
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ جيهان حسين هيبة - مؤلف رئيسي
علم الأدوية والسموم
NAFLD is an umbrella term for a variety of illnesses of ranging severity starts with simple steatosis, develops to non-alcoholic steatohepatitis (NASH), then cirrhosis, and if not controlled, eventually can develop to fibrosis and even hepatocellular carcinoma (HCC). The disease is linked to obesity, insulin resistance, and type 2 diabetes mellitus (T2DM), thus addressing these interconnected disorders could be an effective approach for its management. This review gives an overview the most recent relevant research studies and the on-going therapeutic options for NAFLD focusing on the recently discovered sodium glucose cotransporter 2 inhibitors (SGLT2i), the new antihyperglycemic class of drugs which recently gained adequate popularity, as well as their efficacy and applications in experimental and clinical work.
ORLISTAT /GEMFIBROZIL AMELIORATE TESTICULAR DYSFUNCTION IN STREPTOZOTOCIN-INDUCED DIABETES IN RATS VIA TARGETING VEGF/ NO / PROGRAMMED CELL DEATH FACTOR 4 SIGNALING PATHWAYS / أورليستات / جمفبروزيل يحسن اعتلال الخصية الوظيفي في مرض السكري الناجم عن الستربتوزوتوسين في الجرذان عن طريق استهداف مسارات إشارات عامل موت الخلايا المبرمج VEGF / NO / 4
قطاع الدراسات الصيدلية / علم الأدوية والسموم
تخصص البحث : علم الأدوية والسموم
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 18
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ ريم الخولي - مؤلف رئيسي
علم الأدوية والسموم
One of the complex chronic consequences of diabetes is testicular dysfunction, which is well-known yet still has a murky origin. Objective: With the aim of preventing testicular dysfunction in diabetic rats, we looked into the potential effects of orlistat and gemfibrozil on vascular endothelial growth factor (VEGF) as a marker of angiogenesis, nitric oxide (NO) as an oxidative stress marker, and programmed cell death factor 4 (PDCD4) as an apoptotic marker. Methods: Streptozotocin (STZ, 40 mg/kg/i.p. once) was used to induce diabetes in adult rats, and the treated groups received treatment started one week before induction. Rats were sacrificed three weeks later, and blood samples were obtained for hormonal analysis. Additionally, testicular tissue was examined for testicular oxidative stress, inflammatory markers, and apoptotic markers. Additionally, testicular VEGF and androgen receptors were evaluated, and testicular damage was identified. Results: The results revealed a notable decrease in PDCD4 signaling along with a considerable improvement in inflammatory markers, and oxidative stress status. Conclusion: Our data highlight the significance of VEGF/NO/ PDCD4 signaling pathways in the genesis of testicular dysfunction as a consequence of diabetes mellitus and point to the positive benefits of orlistat and gemfibrozil, either separately or in combination, in reducing testicular damage in diabetic rats.
HEPATOPROTECTIVE AND ANTIOXIDANT EFFECTS OF CAFFEINE AND SILYMARIN COMBINATION BY DECREASING LYSOPHOSPHATIDIC ACID RECEPTOR 3 TISSUE AND GENE EXPRESSION IN RATS / التأثيرات الواقية للكبد والمضادة للأكسدة لمزيج الكافيين والسيليمارين عن طريق تقليل التعبير النسيجي و الجيني لمستقبلات حمض الليزوفوسفاتيدك 3 في الجرذان
قطاع الدراسات الصيدلية / علم الأدوية والسموم
تخصص البحث : علم الأدوية والسموم
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 17
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ سلمى عراقي - مؤلف رئيسي
علم الأدوية والسموم
Liver disease causes about 2 million deaths yearly in the world. Caffeine (Caff) is the most common psychoactive substance utilized around the world. Caff has been demonstrated to possess anti-fibrotic actions in the liver. Silymarin (Sily) is a natural product largely used for its hepatoprotective actions through antioxidant, anti-inflammatory, and anti-fibrotic effects. Aim of the study: The current study aims to investigate the hepatoprotective and antioxidant effects of Caff and Sily alone or in combination in a rat model of liver fibrosis focusing on their effects on lysophosphatidic acid receptor 3 (LPAR3) expression. Materials and methods: 200 mg/kg of thioacetamide (TAA) was injected intraperitoneally twice weekly for 8 weeks to induce liver fibrosis. Caff, Sily, and their combination were orally administered to rats at a dose of 50 mg/kg/day for 8 weeks together with TAA injection. Results: Caff and Sily alone or in combination significantly improved liver function tests compared with fibrotic group. Moreover, they significantly decreased hepatic malondialdehyde (MDA) content and significantly increased the hepatic glutathione (GSH) concentration as compared with the fibrotic group. They significantly decreased fibrosis and necro-inflammatory scores with a superior significant effect in the necro-inflammatory score for the combination group each drug alone. Caff and Sily alone or in combination significantly decreased the hepatic LPAR3 gene and tissue expression, which was significantly correlated to their hepatoprotective effects. Conclusion: Caff and Sily alone or in combination protected against hepatic fibrosis through down-regulation of LPAR3 as well as antioxidant effects.
STUDY THE ANTI-INFLAMMATORY EFFECTS OF TAMSULOSIN BY THE EVALUATION OF INFLAMMATORY CELLS AND LUNG HISTOPATHOLOGY IN AN AIRWAY INFLAMMATION MODEL IN RATS / دراسة تأثير علاج التامسولوسين كمضاد للألتهابات في نموذج التهاب مجرى الهواء عند الجرذان من خلال تقييم الخلايا الالتهابية والتشريح النسيجي للرئة
قطاع الدراسات الصيدلية / علم الأدوية والسموم
تخصص البحث : علم الأدوية والسموم
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 13
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ هالة العبدلي - مؤلف رئيسي
علم الأدوية والسموم
Objective: Study the role of tamsulosin on the respiratory inflammation in rats with ovalbumin (OVA) induced airway sensitization by evaluating the inflammatory cells in the broncho-alveolar lavage fluid (BALF) and the lung histopathology. Materials and methods: Thirty adult male albino rats were allocated into 5 groups (n=6). group A – Normal control (NC) fed commercial pellets and water. group B – (as negative control) – subjected to an airway OVA-sensitization. group C (as positive control) – treated with oral prednisolone (4.12 mg/kg) plus OVA-sensitization. group D – treated with oral tamsulosin (35 mcg/kg/d, equivalent to 0.4 mg for a 70 kg human) plus OVA-sensitization. group E – treated with oral tamsulosin (17.5 mcg/kg/d, equivalent to 0.2 mg tamsulosin for a 70 kg human) plus OVA-sensitization. Inflammatory cells count/µl in the BALF was calculated along with histological analysis of the lung tissue. Results: Both doses of tamsulosin (35 and 17.5 mcg/kg/d) significantly reduced the total WBC count, eosinophils, and neutrophils. A significant reduction in mononuclear cells was detected after treatment with 35 mcg/kg/d tamsulosin. Also, the histopathological examination revealed that both doses (35 and 17.5 mcg/kg/d) of tamsulosin caused less agglomeration of the inflammatory cells within the lung tissue and clear alveolar sacs. Conclusion: the administration of tamsulosin in rats with induced airway sensitization resulted in protection from respiratory inflammatory events.
PRESCRIBING PATTERNS AND PHARMACOLOGICAL KNOWLEDGE OF ANALGESICS AMONG COMMUNITY PHARMACISTS IN JEDDAH, SAUDI ARABIA / أنماط وصف الأدوية والمعرفة الدوائية للمسكنات بين صيادلة المجتمع في جدة بالمملكة العربية السعودية
قطاع الدراسات الصيدلية / علم الأدوية والسموم
تخصص البحث : علم الأدوية والسموم
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ ناصر العرفي - مؤلف رئيسي
علم الأدوية والسموم
Background: Analgesics are frequently used to manage pain, and community pharmacists play a crucial role in prescribing these medications. However, inappropriate prescribing patterns and inadequate pharmacological knowledge of analgesics among pharmacists can lead to adverse health outcomes and increase healthcare costs. Aim: Eevaluating the prescribing patterns and pharmacological knowledge of analgesics among community pharmacists in Saudi Arabia. The study also seeks to identify any potential areas of deficiency in the knowledge or practices of community pharmacists regarding the safe and effective use of analgesics. Ultimately, to enhance the quality of care provided to patients who require analgesic therapy, by addressing any gaps in the knowledge or practices of community pharmacists. Method: In November 2022, a study was conducted in Jeddah to investigate the prescribing skills and level of pharmacological knowledge of analgesics among community pharmacists. The research design used for this study was cross-sectional. Results: One hundred thirty fours community pharmacists responded to the survey. Most participants were male, 31 years old or above, with a Bachelor’s Degree in Pharmacy. Most of the community pharmacists were aware of the correct use, side effects or complications, contraindications, safe dosage, and reaction mechanism of analgesics. The community pharmacists obtained a favorable mean knowledge score (> 50%) of analgesic drugs. Conclusion: Community pharmacists reported correct prescribing patterns and adequate pharmacological knowledge. However, when pharmacists have little community experience their analgesic drug knowledge tends to be weaker, but it becomes stronger after 5 years.
THERAPEUTICAL INTERVENTIONS FOR MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME; A REVIEW OF PHASE IV CLINICAL TRIALS / التدخلات العلاجية لالتهاب الدماغ والنخاع العضلي / متلازمة التعب المزمن ؛ مراجعة المرحلة الرابعة من التجارب السريرية
قطاع الدراسات الصيدلية / علم الأدوية والسموم
تخصص البحث : علم الأدوية والسموم
Bulletin of Pharmaceutical sciences / / vol.46 الجزء الأول لعام 2023 - 1/7/2023
تاريخ تقديم البحث 09/07/2023
تاريخ قبول البحث 28/08/2023
عدد صفحات البحث 10
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ ناصر العرفي - مؤلف رئيسي
علم الأدوية والسموم
Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling and complex illness with multifactorial etiology. Current clinical trials were examined to understand the characteristics of ME/CFS as well as possible therapeutical interventions. Aim: To identify features of clinical trials related to ME/CFS registered at ClinicalTrials.gov, specifically, the therapeutical interventions used to manage the syndrome in phase IV. Method: Analysis of all clinical trials registered at ClinicalTrials.gov for ME/CFS. Those clinical trials that employed a targeted therapy were included. The analysis identified a selection of clinical trials examining a targeted therapy for ME/CFS, providing a platform for further exploration of potential treatments. Results: By November 19th, 2022, 151 clinical trials related to ME/CFS had been found. Interventional studies were the most prevalent type. However, the trials were restricted to specific continents and were not extensively conducted in pediatric patients. Micronutrients were the most commonly used intervention. Phase IV studies had fewer clinical trials with limited interventional measures. Only three out of nine studies completed pharmacological interventional studies, and of these, sodium oxybate was being used most frequently. Conclusion: Among the clinical trials identified through this paper, there were few related to ME/CFS treatment. The interventions in the completed phase IV studies involved drugs that mainly interacted with the CNS, and more rarely that had an effect on blood vessels and blood perfusion. The limited number of phase IV clinical trials meant that the results were inconclusive.
جميع البيانات التي يتم تسجيلها على النظام هي ملك للجهة صاحبة هذه البيانات
لا يتم الاطلاع على هذه البيانات من قبل مهندسي المركز إلا للضرورة القصوى ولغرض الدعم الفني وبالاتفاق مع الجهة صاحبة البيانات شفوياً أو كتابياً
لا يتم إعطاء أي بيان من بيانات النظام لأي فرد او جهة فرعية تنتمي للجهة صاحبة البيانات او لأي جهة أخرى إلا بموافقة كتابية من الجهة صاحبة البيانات
يمكن استخدام البيانات المسجلة على النظام بهدف عمل إحصائيات يستفاد منها فى قياس اداء النظام وكفاءة استخدامه من قبل مستخدميه
يتم تأمين جميع البيانات الخاصة بالنظام من خلال تأمين الحاسب الخادم الذي يستضيف البيانات ومن خلال تأمين انتقال البيانات بين جهاز المستخدم والحاسب الخادم وكذلك تأمين واجهة النظام التي يستخدمها المستخدم
كل مستخدم للنظام مسئول مسئولية كاملة عن كلمة المرور الخاصة به وعليه اتخاذ كافة الاحتياطات الممكنة حتى لا يستطيع أى شخص آخر الحصول عليها
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