A REVIEW OF THEOPHYLLINE’S PHARMACOLOGICAL INTERACTIONS WITH MEDICINAL HERBS / دراسة استعراضية للتفاعلات الدوائية للثيوفيللين مع الأعشاب الطبية
قطاع الدراسات الصيدلية / الصيدلانيات
تخصص البحث : الصيدلانيات
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 09/01/2023
تاريخ قبول البحث 23/01/2023
عدد صفحات البحث 14
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ عصام محمد ابو شمالة - مؤلف رئيسي
الصيدلانيات والصيدلة الصناعية
Theophylline (TPH) is a bronchodilator with a limited therapeutic index and high inter-individual pharmacokinetic (PK) variability. In this paper, the interactions between TPH and medicinal herbs recorded in the literature were summarized. The collected references in the analyzed literature were investigated. A decrease in TPH bioavailability by induction mechanism on CYP1A2 was reported during co-administration of herbs or herbal extracts as (Andrographis paniculata, Commiphora myrrha, Ephedra species, Evodia rutaecarpa, Lepidium sativum, Sophora flavescens, Salvia miltiorrhiza, and Trigonella foenum-graecum). TPH bioavailability was increased by inhibition mechanism on CYP1A2 when co-administered with herbs (Acacia catechu, Angelica species, Astragalus species, Cassia auriculata, Cardiospermum halicacabum and Scutellariae baicalensis. Meanwhile, concomitant use of TPH with (Cassia occidentalis, Glycyrrhiza glabra, Ginkgo biloba, Hypericum perforatum, Nigella sativa, Punica granatum and Rhodiola rosea) was reported to be insignificant. In this review, we focus on the interactions between TPH and medicinal herbs that haven’t been covered in prior studies. To reduce the patients’ health risks, health professionals involved in their treatment are expected to be thoroughly educated about the interactions between TPH and medicinal plants.
NANOSTRUCTURED LIPOSOMES FOR NOSE TO BRAIN DELIVERY OF CARMUSTINE: IN VIVO EVALUATION / الليبوزومات النانوية المهيكلة لتوصيل كارموستين من الأنف إلى الدماغ: التقييم داخل الجسم الحي
قطاع الدراسات الصيدلية / الصيدلة الصناعية
تخصص البحث : الصيدلة الصناعية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 09/01/2023
تاريخ قبول البحث 23/01/2023
عدد صفحات البحث 10
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ ج. نيثرا فاني - مؤلف رئيسي
الصيدلة الصناعية
Nano sized particles are promising mediators for the administration of active compounds in the nasal and cerebral systems. However, the ability to achieve relevant therapeutic concentrations of exogenous molecules in the body is dependent mainly on the capability of nanoparticles to break down biological obstructions. In this work, nanoscale formulations conveying the minimally soluble model drug Carmustine (CS) were discussed. Box Behnken design (QbD tool) was applied to predict the interactions between the independent variable (drug-lipid ratio (X1), cholesterol (X2) and Critical Process Parameters (sonication time, X3) on the dependent variable (Entrapment efficiency (Y1), Particle size (Y2) and in vitro drug release (Y3)). The nano scale liposomal optimized Carmustine formulation (NSL-OCS) was investigated for their effect on the biopharmaceutical facets decisive for nose-to-brain delivery such as permeation across the nasal mucosa. An in vivo pharmacokinetic study was performed in Wistar albino rats via intravenous routes. Histopathologic studies support the absence of evidence of toxicity. In vitro drug dissemination studies show rapid drug release followed by extended release of CS for up to 24 hrs. The Pharmacokinetic parameters of NSLs in brain were higher in intranasal route compared to NSLs administered by intravenous route. The findings showed that the intranasal pathway can be an effective approach to administering the drug straight to the brain and improve the drug’s efficacy in the brain to treat brain tumors and become a good substitute to oral medication.
PREPARATION AND EVALUATION OF COMPRESSED COATED TABLETS USING POLYELECTROLYTE COMPLEX FOR TARGETED DELIVERY OF ANTI-AMOEBIC DRUG / تحضير وتقييم الأقراص المضغوطة المغلفة باستخدام مركب متعدد الإلكتروليت للايصال المستهدف لعقار مضاد للأميبا
قطاع الدراسات الصيدلية / الصيدلانيات
تخصص البحث : الصيدلانيات
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 09/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 16
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ هيمانت رامشاندرا بادويك - مؤلف رئيسي
الصيدلانيات
An unwanted absorption of anti-amoebic drug at upper gastrointestinal tract (GIT) causes numerous side effects and requires higher doses to get therapeutic effect. The primary goal of this study was to develop a secnidazole colon targeted drug delivery system (CTDDS) employing compressed coated tablets (CCT) coated with polyelectrolyte complexes (PECs). The optimized PEC was formulated by using varying ratios of cationic and anionic polymers which have the ability to resist a wide range of pH environment from stomach to colon (acidic, neutral to basic). The in vitro release profile of drug was studied in various simulated physiological conditions i.e., gastric, intestinal and colonic environment. For in vivo evaluation, barium sulfate imaging x-ray technique was used to evaluate the transit behavior of formulation in GIT. The results obtained from physical evaluation have demonstrated uniform diameter, thickness, desired hardness (> 4 kg/cm2), and friability (not more than 1.0%). The Korsmeyer-Peppas model suggested the kinetics of drug release as ‘n> 0.89’ which indicates super case–II transport mechanism. In vivo images have confirmed that the tablet formulations were not disintegrated in the upper stomach and degraded in the colonic area.
LIPID NANOEMULSION-BASED LIQUISOLID COMPACT TABLETS FOR ORAL DELIVERY OF CLOTRIMAZOLE: FABRICATION STRATEGIES, charACTERIZATIONS, ANTIMYCOTIC AND TOXICOLOGICAL EVALUATIONS / أقراص مضغوطة سائلة قائمة على مستحلب النانو الدهني للتوصيل الفمى لعقار كلوتريمازول: استراتيجيات التصنيع ، والتوصيف، وتقييم السمية و الفاعلية المضادة للفطريات
قطاع الدراسات الصيدلية / الصيدلانيات
تخصص البحث : الصيدلانيات
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 09/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 32
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ تشوكويبوكا ايمانويل أوميور - مؤلف رئيسي
الصيدلانيات
This work aims to fabricate liquisolid compact tablets incorporating clotrimazole (CLOT)-loaded lipid nanoemulsions (LNE) for oral treatment of systemic fungal infections. Nanoemulsion was characterized for droplet size, rendered into free-flowing granules and compressed into liquisolid compact tablets, and evaluated using pharmacopoeial and non-pharmacopoeial methods. In-vitro and in vivo antifungal, stability and toxicological tests of the tablets were evaluated. LNE was nanosized (66.7 ± 5.7 – 121.6 ± 3.2 nm). Liquisolid tablets were stable, non-toxic, had uniform weight (341.4 ± 1.2 – 346.7 ± 0.8 mg), drug content uniformity (85.2 ± 0.1 – 99.8 ± 0.2 %), and had excellent disintegration (2.96 ± 0.8 – 5.88 ± 1.3 min), and controlled release property. In-vitro and in vivo antifungal evaluations revealed improved antimycotic activity of CLOT. The results highlight that CLOT-LNE liquisolid compact tablets is a promising carrier system with improved oral utility for the treatment of systemic fungal infections.
REGULATIONS ON GENETICALLY MODIFIED MICROORGANISMS & THEIR RELATION TO BIOTERRORISM IN INDIA / اللوائح المتعلقة بالكائنات الدقيقة المعدلة وراثيًا وعلاقتها بالإرهاب البيولوجي في الهند
قطاع الدراسات الصيدلية / الصيدلانيات
تخصص البحث : الصيدلانيات
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 09/01/2023
تاريخ قبول البحث 23/01/2023
عدد صفحات البحث 20
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ جورفيندر سينغ - مؤلف رئيسي
الصيدلانيات
Covid-19, a virus-driven pandemic, has shown the world the possible dangers posed by microorganisms like bacteria, viruses, rickettsia, fungi, and their toxins. However, genetically engineered microorganisms are helpful in various biosciences fields, including medication, horticulture, and fundamental investigation into life processes. Among these, some genetically altered microorganisms have drastic potential to cause harm to humans, and the environment, like the current coronavirus pandemic has shaken the world with fatalities caused by it worldwide and crashed the global economy. On the one hand, genetically engineered organisms help understand the ultrastructure of these organisms and as a tool to combat the disease caused by them. On the other, the increasing research on this also poses a threat to the occurrence of pandemics throughout the world. In India, genetically altered microorganisms are regulated by the Rules, 1989 under sections 6,8 and 25 of the Environment Act, 1986. Bioterrorism is the systematic and deliberate deployment of hazardous organisms such as bacteria, viruses, or toxins to spread infectious diseases on a massive scale to wipe out a vast population. The global incidents of the recent twenty years presented that the danger of biological fighting isn’t a fictional thing yet a harsh truth. Hazardous microbes can be utilised in bioterrorism by seeing flare-ups brought about by microorganisms. So, there is a need to improve the countermeasures to tackle the spread of infectious diseases. This review covers the various regulations for genetically altered microorganisms in India regarding their sale, import-export storage, and creation, emphasising regulating bodies; their constitution, and application forms for the registrations and approval for research on such microorganisms, and this assessment presents a clear overview of the country’s probable biothreats, current laws, and regulations to combat such incidents, with a significant necessity for their execution, and biodefense measures for readiness and defence, in favour of making India a bioterror-free country.
PHYTOCHEMICAL SCREENING AND PHARMAOCOLOGICAL EVALUATION OF TECOMA GAUDICHAUDI / الفحص الكيميائي النباتي الأولي والتقييم الفارماكولوجي لـنبات تيكوما جاوديكاودي
قطاع الدراسات الصيدلية / العقاقير
تخصص البحث : العقاقير
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 09/01/2023
تاريخ قبول البحث 23/01/2023
عدد صفحات البحث 8
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ ف. ألكيا - مؤلف رئيسي
العقاقير
Tecoma gaudichaudi is a tropical flowering plant in the Bignoniaceae family that is used to treat diabetes. The aim of this research was to evaluate antioxidant, anti-inflammatory, and antibacterial properties. Tecoma gaudichaudi ethanolic extract had considerable antioxidant activity. Antioxidant activity was measured using the DPPH assay, the radical scavenging method, and the superoxide assay. Antibacterial activity and antifungal activity were performed by cup plate method by using Ciprofloxacin as standard for antibacterial and antifungal activity. Ethanolic extract of Tecomo gaudichaudi shows significant antibacterial effect against S. Aureus, B. Subtilis, P. vulgaris and E. coli using ciprofloxacin (50µg/ml) as standard. Three alternative methods were used to calculate IC50 values for antioxidant activity. The IC50 values for T. gaudichaudi (21 g/ml) and ascorbic acid (12 g/ml) were obtained using the DPPH technique. For anti-inflammatory studies the extracts show remarkable zone of inhibition ranging from 58.97 to 72.35 µg/ml respectively compared to standard indomethacin. Steroids, saponins, flavonoids, triterpenes, and phenols are found in preliminary phytochemical investigation. In conclusion, ethanolic extract of Tecomo gaudichaudi shows significant antioxidant, anti-inflammatory and antibacterial properties.
IN-VITRO AND IN-VIVO HYPOGLYCEMIC EFFICACY OF ROSA DAMASCENA PETALS EXTRACTS / الفعالية الخافضة لسكر الدم لخلاصة بتلات الوردة الدمشقية في الزجاج والجسم الحي
قطاع الدراسات الصيدلية / العقاقير
تخصص البحث : العقاقير
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 09/01/2023
تاريخ قبول البحث 23/01/2023
عدد صفحات البحث 12
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ عبد المجيد السلطي - مؤلف رئيسي
العقاقير
Rosa damascena, which belongs to the Rosaceae family, is considered as one of the most important plants used in traditional medicine due to its different pharmacological properties, such as treatment of abdominal and chest pain, menstrual bleeding, and reduction of inflammation. The objective of our study was to investigate the hypoglycemic efficacy of R. damascene. Aqueous and methanolic extracts were prepared from the petals of R. damascena mill (RDM). The phenolic content of the extracts was assessed using the Folin-Ciocalteu colorimetric method. The hypoglycemic activity was evaluated by the determination of in vitro alpha-amylase inhibitory activity. The in vivo post-prandial hypoglycemic effect was performed in normal and alloxan-induced diabetic mice. Acarbose (alpha-glucosidase inhibitor) was used as a standard drug. The total phenolic content of aqueous and methanolic extracts was 29.23 gGAE/l and 58.8 gGAE/l. The alpha-amylase inhibition assay was performed using concentrations of (20, 40, 60, 80, 100, and 120 µg/ml) of aqueous extract, methanolic extract, and acarbose. The percentage inhibition of alpha-amylase was dependent on dose and varied between (33.66-89.96%), (41.57-92.16%) and (23.4-81.82%), respectively. Both aqueous and methanolic extracts revealed higher inhibitory activity of alpha-amylase compared to acarbose. Oral administration of methanolic extract in normal and diabetic mice significantly decreased glucose blood levels after maltose loading in a dose-dependent manner. These results suggest that R. damascena petal extracts might have a hypoglycemic effect. They also imply that R. damascena may have anti-diabetic properties by inhibiting of alpha-glucosidase-mediated carbohydrate absorption in the intestine and lowering postprandial glucose levels.
EVALUATION OF RHEUM PALMATUM RHIZOMES AVAILABLE IN JORDANIAN MARKETS AND INVESTIGATION OF ITS POTENTIAL USE AS HAIR DYE COSMETICS / تقييم ريزومة الراوند المتوفرة في الأسواق الأردنية و فحص إمكانية استخدامها في مستحضرات التجميل
قطاع الدراسات الصيدلية / العقاقير
تخصص البحث : العقاقير
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 09/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 9
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ ليديا كمال الهلسه - مؤلف رئيسي
العقاقير
Context: Dyeing hair with natural components derived from plant material is a common practice since ancient time. Variable colour shadows obtained from different plant extracts. The folkloric practices need optimization to find alternatives for the chemical dyes, which carry loads of health hazards. For decades, people use Rhubarb roots extract in treating chronic constipation and other minor health disorders. The pharmacological effects refer to their active constituents; anthraquinone glycosides. Hair dyeing properties of Rhubarb roots extracts need further scientific investigations. Aims: To evaluate the hair-dyeing properties of rhubarb’s aqueous extract as an eco-friendly alternative to the commercially available hair dyes and to measure the fastness of the produced colour in different conditions. Methods: Identification of the plant material was done according to international specifications. Wool pieces dyed by aqueous extracts of rhubarb’s roots and rhizomes under different conditions. Variables that might be affecting the dyeing process such as concentration, pH, using colour mordant, swelling agent, and dyeing time were studied. Spectroscopic methods used to record colourfastness measurements. Results and Conclusion: The extract of rhubarb roots and rhizomes show good dyeing properties. The obtained colours were pale yellow, intense yellow and pink. Colour fastness is enhanced and optimized using 2 mg/ml concentration, 2 h dyeing time, acidic pH, adding mordant and pretreating the fibres with a swelling agent.
ESTIMATION, charACTERIZATION OF PHENOLICS COMPOUNDS AND IN VITRO EVALUATION OF THE ANTIOXIDANT ACTIVITY OF THYMUS FONTANESII BOISS ET REUT EXTRACTS / تقدير و تشخيص المركبات الفينولية، واظهار مختبريا النشاط المضاد للأكسدة للمستخلص الهيدروكحولي و أجزائه العضوية لنبات REUT THYMUS FONTANESII BOISS ET
قطاع الدراسات الصيدلية / العقاقير
تخصص البحث : العقاقير
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 09/01/2023
تاريخ قبول البحث 23/01/2023
عدد صفحات البحث 13
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ أحمد نواصري - مؤلف رئيسي
العقاقير
This study aimed to investigate the hydro methanolic extract and its fractions of aerial parts from Thymus fontanesii Boiss et Reut for their total phenolic and flavonoid contents, characterization of compounds in hydro methanolic extract, and antioxidant activity. The total phenolic and flavonoids were determined by Folin-Ciocalteu and aluminium chloride methods, respectively. The characterization of the crude hydromethanolic extract was done by HPLC UV-DAD, 2, 2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and -carotene–linoleic acid tests were used to assess antioxidant activity in vitro. The extracts’ total phenolic and flavonoid concentrations ranged from 14.56–237.6 mg gallic acid equivalent (GAE)/g. extract and 1.63–2.27 mg quercetin equivalent (QE)/g extract, respectively where the ethyl acetate fraction has the highest value. The characterization of hydro methanolic extract has revealed the presence of salicylic acid, coumaric acid, rosmarinic acid synergistic acid, naringenin 7-glucoside, and luteolin 7-glucoside. The results of antioxidant tests indicated that for the antiradical test the diethyl ether fraction exhibited stronger antioxidant activity, for the FRAP test methanolic extract was more active than other fractions, at least the chloroform fraction was the stronger protector of ?-carotene–linoleic acid system against lipids oxidation. Considering these results T. fontanesii Boiss et Reut aerial part can be used for developing antioxidants, that can act against various oxidative diseases.
PROSPECT OF NATURAL COMPOUNDS AGAINST MALARIA: A REVIEW / مركبات طبيعية محتملة ضد الملاريا: بحث مرجعي
قطاع الدراسات الصيدلية / العقاقير
تخصص البحث : العقاقير
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 09/01/2023
تاريخ قبول البحث 23/01/2023
عدد صفحات البحث 25
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ جايا باركاش ياداف - مؤلف رئيسي
العقاقير
Malaria is one of the leading life-threatening vectors borne diseases prevalent in tropical and subtropical regions of the world. The traditional system of medicine uses drugs of plant origin. Quinine and artemisinin, two naturally occurring plant chemicals, are traditionally used to treat malaria. The present reviews have emphasized the anti-malarial activity of plants that are effective against emerging resistance. The aim of the present study was to analyze the concept and objectives of isolated natural compounds, their mechanism of action, and plant parts used for malaria treatment in the traditional system of medicine. 113 isolated compounds, plant parts used from 49 species, and molecular mechanism of 70 anti-malarial natural compounds from various plant species were explored. These plants were traditionally used for malaria treatment worldwide. They are therapeutically more effective, safer, and traditionally reported for having high cure rates. There is an urgent need for the development of novel drugs to treat malaria. These isolated compounds may be explored for the development of antimalarial drugs against plasmodium-resistant strains.
PHARMACOGNOSTIC STUDY AND ANTIOXIDANT ACTIVITY OF SUNGKAI (PERONEMA CANESCENS JACK.) METHANOL EXTRACT from INDONESIA / دراسة العقاقير والنشاط المضاد للأكسدة من مستخلص الميثانول لنباات سانجكاي (برونما كانسينس جاك) من إندونيسيا
قطاع الدراسات الصيدلية / العقاقير
تخصص البحث : العقاقير
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 09/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ محمد رزكي فضيل براتاما - مؤلف رئيسي
العقاقير
Sungkai (Peronema canescens Jack.) from South Kalimantan, Indonesia, are used to treat fever and increase body immunity. This study aims to establish pharmacognostic standards that include specific and non-specific parameters and determine the antioxidant activity of methanol extract of P. canescens leaves. P. canescens leaves were taken from South Kalimantan, Indonesia, and were processed into simplicia according to the standards. The extraction was carried out using methanol and maceration techniques, then investigated covering specific and non-specific parameters. Antioxidant testing was carried out by TLC and DPPH assay. The results showed that drying shrinkage was 7.43%, total ash content was 4.10%, and acid-soluble ash content was 0.23%. Simplicia of P. canescens leaves was green in color, had a strong taste, and a characteristic odor, as well as some cell parts from microscopic observations. This study provides an overview of P. canescens, including specific and non-specific parameters that meet herbal medicine standards.
ANTI-INFLAMATORY AND ANTI-LIPID PEROXODATION POTENTIALS OF SALVIA CHUDAEI BATT. et TRAB. AND LAVANDULA ANTINEAE MAIRE: ENDEMIC PLANTS from ALGERIAN SAHARA / المضاد الكمون للالتهاب و أكسدة الليبيدات لكل من SALVIA CHUDAEI BATT. et TRAB. AND LAVANDULA ANTINEAE MAIRE، نباتين مستوطنين من صحراء الجزائر
قطاع الدراسات الصيدلية / العقاقير
تخصص البحث : العقاقير
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 09/01/2023
تاريخ قبول البحث 23/01/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ نواصري أحمد - مؤلف رئيسي
العقاقير
The present study was undertaken to investigate the anti-inflammatory and anti-lipid peroxidation activities of two endemic plants of the central Sahara; Salvia chudaei Batt. et Trab and Lavandula antineae Maire (Lamiaceae), as well as their chemical composition of hydromethanolic extracts. In the test of carrageenan-induced oedema in mice, L. antineae extract, at the dose of 200 mg/kg, revealed good anti-inflammatory activity (P?0.05) showing 80.74% reduction in the paw thickness comparable to that produced by the standard drug aspirin an83.44% at 4h, while S. chudaei extract was found to have moderate activity (50.74%). When the plant extracts were applied topically at a dosage of 1 and 2 mg per ear, the reduction of ear oedema inflammation was very remarkable compared to the mice of the control group. The plant extracts also showed anti-lipid peroxidation activity with no significant difference compared to ascorbic acid (77.63 ± 1.58%). In addition, the chemical characterization of two extracts by HPLC-DAD revealed the presence of various phenolic acids and flavonoids. These findings showed that Lavandula antineae and Salvia chudaei displays remarkable anti-inflammatory and anti-lipid peroxidation activities and hence can be potential natural sources in health and medicine.
ESSENTIAL OIL COMPOSITION AND CYTOTOXICITY OF Decaspermum parviflorum (Lam.) A.J.Scott from MALAYSIA / التركيب الكيميائي والسمية الخلوية للزيت المستخلص من نبات ديكاسبرموم بارفيلوروم (لام) إيه جي سكوت من ماليزيا
قطاع الدراسات الصيدلية / العقاقير
تخصص البحث : العقاقير
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 09/01/2023
تاريخ قبول البحث 23/01/2023
عدد صفحات البحث 6
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ وان محمد نزول حكيمي وان صالح - مؤلف رئيسي
العقاقير
The present study analyzed the chemical composition and evaluated the cytotoxicity of essential oil extracted from Decaspermum parviflorum (Lam.) A.J.Scott (Myrtaceae). The chemical composition of the essential oil was analyzed using gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). Thirty-five components were identified, accounting for 97.3% and comprising mainly of monoterpene hydrocarbons, 52.5%. ?-Pinene (40.5%), ?-pinene (9.2%), ?-eudesmol (8.0%), globulol (7.5%), and ?-caryophyllene (5.1%) were identified as its major components. The oil exhibits potent cytotoxicity (IC50 values of 68.5-70.2 ?g/mL) against three human cancer cell lines; HepG2 (liver), MCF7 (breast), and A549 (lung). This is the first report on the chemical composition and cytotoxicity of D. parviflorum essential oil from the context of Malaysia in this study. The present study highlights the potential of using essential oil as an excellent alternative for the development of anticancer chemotherapeutic agents for the pharmaceutical industry.
قطاع الدراسات الصيدلية / الكيمياء العضوية الصيدلية
تخصص البحث : الكيمياء العضوية الصيدلية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 09/01/2023
تاريخ قبول البحث 23/01/2023
عدد صفحات البحث 9
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ جايبراكاش ن. سانججتي - مؤلف رئيسي
الكيمياء العضوية والدوائية
The emergence of resistance in the immunocompromised patients against existing anticandidal agents makes them ineffective causing high incidence and accompanying mortality due to the fungal infections. The generation of biofilms by various species of candida is the most frequent underlying mechanism in the emergence of resistance. Biofilms are defined as encapsulated complex microbial colonies in extracellular polymeric substances (EPS) matrix. The development of newer anticandidal with lower resistance remains a challenging task for researchers. We herein report, a series of N-(substituted benzylidene)-4,6-dimethoxypyrimidin-2-amine analogs along with their antibiofilm and anticandidal potential in-vitro. Compounds 3a, 3b, 3i, 3k, and 3l have shown better inhibition against C. albicans than Fluconazole (standard anticandidal agent). Compounds 3a, 3b, and 3i also exhibited good antibiofilm activity suggesting their antibiofilm as well as anticandidal potential. The results show that the new compounds could serve as an important lead in the discovery of effective anticandidal agents to overcome the resistance problem associated with the existing anticandidal agents.
AN IN-SILICO STUDY OF SOME NATURAL AND SYNTHETIC COMPOUNDS AS POTENTIAL INHIBITORS FOR FACTOR XA / دراسة في السيليكو لبعض المركبات الطبيعية والاصطناعية كمثبطات محتملة للعامل العاشر
قطاع الدراسات الصيدلية / الكيمياء الدوائية
تخصص البحث : الكيمياء الدوائية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 09/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 14
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ غالية صباغ - مؤلف رئيسي
الكيمياء الدوائية
Recent research has demonstrated the significance of factor Xa and its inhibitors as a possible treatment approach. Since currently approved drugs have a wide variety of side effects, new anticoagulants must be developed. So, the goal of this in silico research is to find molecules that may act as factor Xa inhibitors. The structure of factor Xa (2w26) was obtained from the Protein Data Bank database, while the structures of the organic compounds were obtained from the ZINC database or via other means. In order to verify the anti-factor Xa action of these chemical compounds, iGemDock program was used to perform molecular docking. The compound (1) [5-hydroxy-2-(3-hydroxy-4-phenylmethoxyphenyl)-3,7-bis(phenylmethoxy)chromen-4-one] showed the best interaction value against the 2w26 enzyme, and the binding energy was (–167.702 kcal/ mol); whereas the reference rivaroxaban was (–149.661 kcal/mol). These results lead to suggest new organic compounds as factor Xa inhibitors and further in vitro studies are required to confirm.
CHROMATOGRAPHIC ISOLATION, IDENTIFICATION AND charACTERIZATION OF SOME CHEMICAL CONSTITUENTS OF PETROSELINUM CRISPUM LEAVES AND EVALUATING AS HEPATOPROTECTIVE AGENTS / فصل كروماتوجرافي و تعريف وتوصيف لبعض المركبات الكيميائيه لاوراق نبات بيتروسلينيم كرسبم و تقييمها كعوامل واقيه للكبد
قطاع الدراسات الصيدلية / الكيمياء الدوائية
تخصص البحث : الكيمياء الدوائية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 09/01/2023
تاريخ قبول البحث 23/01/2023
عدد صفحات البحث 13
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ إيمان مرسي - مؤلف رئيسي
الكيمياء الدوائية
Petroselinum crispum Mill. (family Apiaceae) is widely used as an essential spice due to its health benefits. This study aimed to investigate the constituents of P.crispum aerial parts and evaluate its hepatoprotective activity. Ethyl acetate and n-butanol fractions of P. crispum subjected to different chromatographic separation techniques. The compounds were identified on the basis of spectral data and compared with previously reported data. Also, the methanolic extract and n-butanol fraction were evaluated for in-vivo hepatoprotective activity against carbon tetrachloride (CCl4) induced hepatotoxicity in mice (10 groups; 8 mice/group). All groups intraperitonially injected by CCl4 (0.5mg/kg b.w., i.p.) in single dose at 11th day, the treated groups received (100, 200, 300, 400 mg/kg b.w.) of MeOH extract and BuOH fraction separately for 14 days. The results revealed that seven compounds were isolated from EtOAc and n-BuOH fractions which were identified as ?-sitosterol (1), quercetin (2), isorhmentin (3), apigenin (4), apigenin-7-O-?-D-glucopyranoside (cosmosiin) (5), diosmetin-7-O-?-D-glucopyranoside (6), apigenin 7-O-?- D- apiofuranosyl (1?2)-?- D glucopyranoside (apiin) (7). On other hand, CCl4 – induced hepatotoxicity cleared in severe liver damage, showed elevation of liver enzymes. The MeOH extract and n-BuOH fraction exhibited significant hepatoprotection in improvement liver enzymes, with a propensity to return to near-normal levels. So, P. crispum extracts are promising in-vivo hepatoprotective activity.
EVALUATION OF BIOLOGICAL ACTIVITIES OF MATRICARIA PUBESCENS from ALGERIA / تقييم الأنشطة البيولوجية لماتريكاريا بوبسينس من الجزائر
قطاع الدراسات الصيدلية / الكيمياء التحليلية الصيدلية
تخصص البحث : الكيمياء التحليلية الصيدلية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 23/01/2023
عدد صفحات البحث 14
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ محمد طاهر بن موسى - مؤلف رئيسي
الكيمياء التحليلية الصيدلية
Abstract: Matricaria pubescens is a plant of the asteraceae family that grows wild in Algeria and throughout North Africa especially in the desert. It is commonly used as folk medicine to cure a variety of ailments in various preparations, aerial parts of the plant were sampled from two different sites in Algeria, the biological activities of the methanolic extracts and essential oils have been evaluated namely antioxidant, anti-inflammatory, antidiabetic, antibacterial, and antifungal activities, besides a safety bioassay , The essential oils of the plant have shown significant efficacy against the studied bacteria, and a strong antifungal activity against Candida albicans. Methanolic extracts and essential oils have shown noticeable anti-inflammatory activity. The essential oils showed good antidiabetic activity and weak antioxidant power. Meanwhile Matricaria pubecens essential oils noted significant cytolytic effect that may hamper its systemic use, it also noteworthy to mention the variability between the samples confirming the differences in the chemical patterns.
QUALITATIVE, QUANTITATIVE, AND MICROSCOPIC EVALUATION OF SYRIAN PANAX GINSENG PRODUCTS / التقييم النوعي والكمي والمجهري لمنتجات باناكس الجنسنج السوري
قطاع الدراسات الصيدلية / الكيمياء التحليلية الصيدلية
تخصص البحث : الكيمياء التحليلية الصيدلية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 23/01/2023
عدد صفحات البحث 9
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ نوار أحمد - مؤلف رئيسي
الكيمياء التحليلية الصيدلية
The use of Panax Ginseng (PG) products is continuously expanding around the world. The popular belief said herbal products are always “safe”, because of its natural source. However, evidences that indicate its quality before marketing are very limited. Although PG products have shown promising potential with the efficacy, many of these products remain untested. This work aims to evaluate some quality aspects of PG products in regard with Qualitative, Quantitative (total Ginsenosiedes content (TGC)), microscopic, Loss On Drying (LOD) tests and in comparison with PG crude plant. The qualitative test revealed the presence of flavonoids, alkaloids, glycosides, and saponins with the exception of tannins. The TGC ranged from (31.16 to102.58 mg/g). Microscopic findings revealed the presence of parenchyma cells with gelatinous content in product A. Moreover, Most of the products exceeded the reference limits for LOD. This process is becoming increasingly important, along with ‘quality control/assurance’, as a means of ensuring a consistent supply of high-quality herbal medicines.
FOURIER TRANSFORM INFRARED SPECTROSCOPY FOR QUANTITATIVE DETERMINATION OF VALSARTAN IN BULK MATERIALS AND IN PHARMACEUTICAL DOSAGE FORMS / مطيافية الأشعة تحت الحمراء باستخدام تحويل فورييه للتحديد الكمي للفالسارتان في المواد الأولية والأشكال الصيدلانية
قطاع الدراسات الصيدلية / الكيمياء التحليلية الصيدلية
تخصص البحث : الكيمياء التحليلية الصيدلية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 23/01/2023
عدد صفحات البحث 14
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ نجوى هرشو - مؤلف رئيسي
الكيمياء التحليلية الصيدلية
The present paper illustrates the potential applications of Fourier Transform Infrared Spectroscopy (FT-IR) in pharmaceutical analysis. A simple, rapid, non-destructive and green (FT-IR) spectroscopy method for quality control evaluation of valsartan was developed, using potassium bromide (KBr) as a matrix to quantify the drug in bulk pharmaceutical materials and in pharmaceutical dosage forms. The sample preparation was avoided except grinding for disk composition and excluded the use of organic solvents. Absorbance obtained for the carbonyl band (C=O) located at 1732 cm-1 was used for the development of calibration curve based on simple Beer-lambert’s law. Method validation was performed according to the International Conference on Harmonization (ICH) guidelines. Linearity, accuracy, precision, robustness and selectivity were evaluated and showed acceptable results for method validation in the concentration range of (0.5 - 2.5% w/w). The developed and validated method was suitable for the quality control analysis of valsartan in bulk materials and in pharmaceutical dosage forms.
DEVELOPMENT OF FOUR UV-SPECTROMETRIC TECHNIQUES FOR CONCURRENT ESTIMATION OF ASPIRIN AND SILDENAFIL CITRATE IN THEIR BINARY MIXTURE AND PHARMACEUTICAL FORMULATIONS / تطوير أربع تقنيات طيفية للأشعة فوق البنفسجية للتحديد المتزامن للأسبرين وسيترات السيلدينافيل في مزيجهما الثنائي وفي التركيبات الصيدلانية
قطاع الدراسات الصيدلية / الكيمياء التحليلية الصيدلية
تخصص البحث : الكيمياء التحليلية الصيدلية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 23/01/2023
عدد صفحات البحث 13
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ أمير الحاج صكر - مؤلف رئيسي
الكيمياء التحليلية الصيدلية
The combination of aspirin (ASP) and sildenafil citrate (SIL) into single dosage form has been of interest for a considerable period; because it has a synergistic effect for the handling of many diseases. Therefore, UV-spectrometric techniques were desperately required for the concurrent estimation of ASP and SIL in their binary mixture and pharmaceutical formulations. In this paper, four simple, low-cost and precise UV-spectrometric techniques were evolved for the concurrent estimation of ASP and SIL. The advanced methods include treatment of the zero-order spectrum by ratio subtraction (RS) along with spectrum subtraction method (SS), absorption correction method (ACM), area under the curve correction method (AUCCM) and induced dual wavelength method (IDWM). Moreover, UV-spectrometric purity analysis via spectral ratio factor (SRF) was developed; which considered the first UV-spectrometric purity testing to verify the purity of ASP in pharmaceuticals formulations. All approaches were linear; in the range of 25.0-100.0 ?g/mL for ASP, and 10.0-50.0 ?g/mL for SIL. The mean percentage recoveries for ASP were 100.92, 100.33, 100.79 and 100.18% respectively, and for SIL were 99.27, 99.56, 99.83 and 99.44% respectively. The SRF values were approximating unity and showed high purity of the resolved peaks. The results were statistically compared with the HPLC reported method and no significant variance was discerned
EMPIRICAL MODELING FOR REPORTED CASES AND DEATHS OF COVID-19 IN EGYPT DURING THE ACCELERATED SPREAD AND PREDICTION OF THE DELAYED PHASE / النموذج التجريبي لحالات COVID- 19 المسجلة و الوفيات الناتجة عنها في مصر أثناء الانتشار المتسارع والتنبؤ بالمرحلة الاخيرة
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 15
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ محمد أ حمد مدحت - مؤلف رئيسي
الصيدلة الإكلينيكية
This is a newly developed conceivable mathematical model for analyzing the spreading behavior of COVID-19 during the first wave of the pandemic in Egypt. We emphasized the impact of detection and control measures in flattening the spread of disease. This knowledge of the early spread dynamics of infection and assessing the efficiency of control measures is critical for reviewing and evaluating the potential for sustained transmission to occur during the coming waves. This proposed empirical model for the accelerated spread phase is based on non-linear regression technique, interpolations, tangents, least-square, and optimization methods to delimit different phases of the pandemic and predict the delayed phase. We prove that our model is mathematically consistent and present various simulation results using the best-estimated parameter value. The model can be easily updated when restrictions and other issues become changed. These simulation results may guide the local authorities to make timely right decisions.
THERAPEUTIC EFFICACY OF ORAL VERSUS INTRAVENOUS VITAMIN K IN PATIENTS WITH LIVER CIRRHOSIS / الدور العلاجي لفيتامين ك المعطي عن طريق الفم مقابل الوريد في مرضى تليف الكبد
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 12
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ سحر بدر حسن - مؤلف رئيسي
الصيدلة الإكلينيكية
Objective: Patients with liver cirrhosis have different complications including bleeding disorders, due to vitamin K-dependent coagulation factors deficiency. Vitamin K is administered to correct bleeding complications, however the evidence for its efficacy either orally or intravenously is lacking. This study aimed to assess therapeutic role of vitamin K in cirrhotic patients.Methods: A prospective observational study was conducted on ninety liver cirrhotic patients at Al-Rajhy Liver Hospital. Patients received vitamin K orally (N= 45) or intravenously (N= 45) at doses of 10 mg/day for 3 successive days. Prothrombin time (PT), international normalization ratio (INR), serum vitamin K level, hemoglobin, liver and kidney function were assessed at baseline and after 3 days of vitamin K administration. Child-Pugh score and bleeding signs were reported. Results: After vitamin K administration, vitamin K serum level was significantly increased in the oral and the IV group. PT and INR were significantly decreased in the oral and the IV groups. Vitamin K serum level had negative significant correlation with PT (r= -0.42, P= 0.033) and INR (r= -0.40, P= 0.038). Conclusion: Oral and IV vitamin K administration showed similar efficacy in improving PT, INR and bleeding signs. Child B class patients more benefited from vitamin k administration than Child C class..
ASTRAZENECA AND SINOPHARM VACCINES ADVERSE EFFECTS AT FIRST AND SECOND DOSES. CROSS SECTIONAL STUDY EGYPTIAN EXPERIENCE / الآثار السلبية للقاح الاسترازينيكا وسينوفارم في الجرعات الاولي والثانية
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 9
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ مروة كمال - مؤلف رئيسي
الصيدلة الإكلينيكية
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that causes severe acute respiratory syndrome (SARS). It was discovered in December 2019 in Wuhan, China., which subsequently led to a nationwide outbreak. The World Health Organization included the AstraZeneca and Sinopharm vaccines for the WHO Emergency Use List on February 16 and May 7, 2021, respectively. Egyptians have gotten 2,623,200 doses of AstraZeneca’s COVID-19 vaccination plus 500,000 doses of Sinopharm vaccine. The trial would test the vaccinations’ short-term side effects on Egyptian people aged 18 and older. Results: Most symptoms decreased significantly after the second dose when compared to symptoms seen at the first dose .In addition, both doses reduced symptoms significantly compared to the first dose.Interestingly, the desire to sleep appears to significantly increase the side effects again after both doses when compared to the second dose alone. The majority or nearly all of the participants (96.5%) had no infection after vaccination. Conclusion: Mild to moderate side effects are to be expected after the vaccination process because the body’s immunomodulatory instructions can lead to negative symptoms. Symptoms include injection site soreness, fever, tiredness, headache, muscle aches, chills, and diarrhoea.. The majority or nearly all of the participants (96.5%) had no infection after vaccination. Training and continuing education are needed to improve universal vaccine acceptance and reduce frequency.
PREVALENCE OF ANTIBIOTICS RESISTANCE AMONG PATIENTS UNDERGOING BRONCHOSCOPY IN CHEST DEPARTMENT AT AL-SHIFA MEDICAL COMPLEX IN GAZA STRIP, PALESTINE / انتشار مقاومة المضادات الحيوية لدى المرضى الذين خضعوا لتنظير القصبات الهوائية في قسم الصدر في مجمع الشفاء الطبي بقطاع غزة - فلسطين
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 12
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ عبد الحميد البلبيسي - مؤلف رئيسي
الصيدلة الإكلينيكية
Background: This study was conducted to determine the prevalence of antibiotics resistance among patients undergoing bronchoscopy in Chest Department at Al-Shifa Medical Complex. Method: This cross-sectional study was conducted in year 2021. A total of 88 patients who were admitted to the Chest Department to undergo bronchoscopy during the study period were included. A 176-bronchoalveolar lavage (BAL) samples were stained and cultured for bacteria and fungi. Isolated bacteria from the BAL samples were identified, and antimicrobial susceptibility testing was conducted. Statistical analysis was performed using the SPSS version 22 program. Results: Fifty-five (62.5%) of the patients were males, and 33(37.5%) were females. About 47(53.4%) of the BAL samples were positive bacterial cultures; 32(36.4%) of the BAL samples were positive fungal cultures. Among the isolated 39(83%) gram-positive bacteria, Streptococcus pneumoniae bacteria was the predominant pathogen in 35(89.7%) isolates. Among the isolated eight (17%) gram-negative bacteria, Pseudomonas aeruginosa was found to be the predominant organism in four (50%) isolates. Among the total of 32 fungal isolates samples, 15(46.9%) were Candida fungi detected, making it the most predominant pathogen. Conclusion: All bacteria as Streptococcus pneumoniae, Staphylococcal aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae were multiple drug resistance bacteria. Streptococcus pneumoniae is mainly susceptible to Rifampicin, whereas Gentamicin and Rifampicin are effective antimicrobial agents against Staphylococcal aureus. The effective antimicrobial agents against Pseudomonas aeruginosa were Amikacin, Colistin, Ceftazidime and Ciprofloxacin. Colistin and Doxycycline were the best effective drugs against each of Klebsiella pneumoniae and Escherichia coli. Additionally, Candida fungi were the most predominant pathogens.
THE EFFICACY OF SALVIA OFFICINALIS IN ON PROMOTION OF SEXUAL FUNCTION IN POSTMENOPAUSAL WOMEN: A DOUBLE-BLIND RANDOMIZED CONTROLLED CLINICAL TRIAL / فعالية سالفيا اوفيسيناليس في تعزيز الوظيفة الجنسية عند النساء بعد سن اليأس: تجربة سريرية عشوائية مزدوجة التعمية
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 9
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ أكبر زاده مرزية - مؤلف رئيسي
الصيدلة الإكلينيكية
Menopause is a stage in women’s life usually associated with sexual dysfunction. Estrogen plays a significant role in women’s sexual well-being. This study aimed to evaluate the effect of Salvia Officinalis extract on the sexual function of postmenopausal women. This was a double-blind randomized clinical trial on 66 eligible postmenopausal women referring to the Bone Density Measurement Center of Namazi Hospital in Shiraz, Iran in 2015. Subjects in the intervention and control groups daily received three tablets of Salvia Officinalis extract and a placebo, respectively. A sexual function questionnaire with domains of sexual arousal, lubrication, orgasm, and sexual satisfaction was completed for them at the baseline and 3 months after the intervention. Data were analyzed with SPSS-21 software using paired t-test at a significance level of 0.05. The mean score of sexual function, sexual desire, orgasm, sexual satisfaction, and pain relief in the Salvia Officinalis group increased after the intervention by 4.6, 1.1, 0.9, 1.1, and 0.5 units, respectively, which were significantly different from those of the control group. However, the mean score of sexual arousal did not show a statistically significant difference (P= 0.082). Due to the positive effect of Salvia Officinalis on sexual performance scores, it is recommended to be used as a supplement during menopause. Although no significant side effects were observed, further studies are recommended.
ASSOCIATION BETWEEN FOXP3 (RS3761548) PROMOTER POLYMORPHISM WITH VITILIGO PATIENTS, THEIR CLINICAL DATA AND RESPONSE TO PHOTOTHERAPY: A STUDY from EGYPT / الارتباط بين (3761548rs)FOXP3 تعدد الأشكال المحفز مع مرضى البهاق ، وبياناتهم السريرية والاستجابة للعلاج بالضوء: دراسة من مصر
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/مها عبد السلام - مؤلف رئيسي
الصيدلة الإكلينيكية
Background: The rs3761548 polymorphism (3279 C> A) of the FOXP3 gene is associated with several autoimmune disorders. Its role in vitiligo has not been well studied.We sought to investigate whether rs3761548 polymorphism is associated with vitiligo in Egyptian subjects. Methods:Case-control study where genomic DNA was isolated from blood samples of 100 patients and 100 control subjects and genotyping was done by allele-specific primers. Given that FOXP3 is an X-linked marker, data analysis was done for the entire cohort and then stratified based on the gender. Results:The genotype frequencies differed significantly from patients to control subjects showing that AC genotype was significantly higher in the patient group than control subjects (risky genotype ) despite of the protective nature of CC genotype which observed in our study. According to the alleles , the A allele was higher in the patient than in the control group .Insignificant results were reported according to the association between FOXP3 (rs3761548) promoter polymorphism and clinical data of patients and their response to phototherapy.Conclusions: The rs3761548 of FOXP3 gene may be associated with susceptibility to vitiligo because of altered expression.Both the A allele and AC genotype were significantly associated with vitiligo .
EVALUATION OF CURRENT PRACTICE OF STRESS ULCER PROPHYLAXIS IN PATIENTS ADMITTED TO INTENSIVE CARE UNITS IN THE GAZA STRIP- PALESTINE / تقييم استخدام أدوية الوقاية من قرحة الإجهاد لدى مرضى العناية المركزة في قطاع غزة / فلسطين
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 13
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ هلا زكريا إبراهيم الأغا - مؤلف رئيسي
الصيدلة الإكلينيكية
This study aimed at assessing the degree of adherence of Stress ulcer prophylaxis (SUP) practice to the American Society of Health-System Pharmacists (ASHP) guidelines in intensive care units (ICUs) at three hospitals in the Gaza Strip, Palestine. This was a prospective study that utilized chart review methodology for data collection. Four aspects of SUP practice were assessed: indication, dose, route of administration and duration. The study enrolled 442 ICU patients with a median (Interquartile range, IQR) age of 49.0 (36.6) years. More than half the patients (55.7%) were males. Coagulopathy was the most common major risk factor for stress ulcer, presented in 73 (16.5%) patients, while the use of corticosteroid therapy was the most common minor risk factor presented in 93 (21%) patients. SUP was administered to 426 (96.4%) patients, of which 86.9% received ranitidine and 13.1% received PPIs. Overall adherence and indication adherence rates to guidelines were 16.7% and 36.4%, respectively. Appropriate dose, route and duration of SUP were found in 63.6%, 68.2%, and 88.1% of the evaluated doses, respectively. Of the 426 patients prescribed SUP, 48 (11.3%) developed adverse effects. This study revealed suboptimal SUP practice in the investigated hospitals and the need to apply strategies to improve SUP use patterns.
ROLE OF HELICOBACTER PYLORI ERADICATION USING CLARITHROMYCIN-BASED TRIPLE THERAPY IN PATIENTS WITH IRRITABLE BOWEL SYNDROME / دورالتخلص من بكتريا هيليكوباكتر بيلوري باستخدام العلاج الثلاثي القائم على كلاريثروميسين في المرضى الذين يعانون من متلازمة القولون العصبي
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 10
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ هايدى كرم الله رمضان - مؤلف رئيسي
الصيدلة الإكلينيكية
Background: Association between Helicobacter pylori (H. pylori) and irritable bowel syndrome (IBS) remains controversial. We evaluated the changes in symptoms and quality of life (QOL) in IBS patients following H. pylori eradication using clarithromycin-based triple therapy. Methods: Patients with moderate or severe IBS and positive H. pylori stool antigen were included and received clarithromycin-based triple therapy, followed by testing for H. pylori eradication after one month. IBS symptoms and IBS-QOL questionnaire were evaluated at the baseline and after H. pylori eradication. Results: 108 patients had H. pylori eradication. Following eradication, 66 patients reported IBS symptoms improvement, while 42 did not. The improved patients were significantly younger; mean age was 38.1 ± 11.7 (p= 0.03). IBS-C type predominated (42.4%) and postprandial fullness and early satiety as dyspeptic symptoms were higher in the improved group. The non-improved group showed a decrease in IBS-QOL subscales, significantly observed in dysphoria, interference with activity, health worry, and social reaction domains. The total IBS-QOL score was significantly higher in the improved versus the non-improved group (p= 0.000). Conclusion: H. pylori eradication did not improve IBS symptoms or QOL in all patients with IBS. QOL improved in young patients with dyspeptic symptoms and the IBS-C subtype.
PHARMACISTS’ KNOWLEDGE AND ATTITUDES ABOUT ADRS REPORTING AND PHARMACOVIGILANCE PRACTICE IN EGYPTIAN HOSPITALS” / معرفة الصيادلة ومواقفهم حول تقارير التفاعلات الدوائية الضارة وممارسة اليقظة الدوائية في المستشفيات المصرية
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 14
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ مروة كمال - مؤلف رئيسي
الصيدلة الإكلينيكية
Background: Pharmacovigilance is the practice of discovering and reducing risks associated with pharmaceutical products, as well as improving patient safety by evaluating the risk-benefit ratio of medications. The current study looked at pharmacists’ knowledge, attitudes, and practices regarding ADR reporting, as well as the factors that may influence reporting. Methods: A cross-sectional questionnaire-based survey was conducted to collect data from 258 pharmacists from May 2020 to September 2021. A pre-designed questionnaires evaluating knowledge, attitude and practice were distributed and filled questionnaires were collected and analyzed. Results: More than third of pharmacists were unsure to whom ADRs reports should be reported , and about 26.36% said ADRs should be reported to the national ADR monitoring center. More than third group of pharmacists (34.11%) said that pharmacists are responsible for reporting ADRs, while (65.89%) said that all healthcare providers should report ADRs. Conclusions: Most pharmacists had sufficient knowledge of pharmacovigilance and maintained a positive attitude towards ADRs reporting. Education and training of ADRs reporting can be used as one of the planning strategies to improve the reporting rate. This trial is registered with ClinicalTrial.gov, number NCT05224804.
ASSESSMENT OF NEW PREDICTING BIOMARKERS OF POLLUTION TOXICITY IN WORKERS OR INDIVIDUALS LIVING CLOSE TO OIL REFINERY AREA IN AL-MUTHANNA CITY, IRAQAS ALARM INDICATORS FOR CLINICAL DISORDERS / تقييم المؤشرات الحيوية الجديدة للتنبؤ بسمية التلوث لدى العمال أو الأفراد الذين يعيشون بالقرب من منطقة مصفاة النفط في مدينة المثنى، العراق كمؤشرات إنذار للاضطرابات السريرية
قطاع الدراسات الصيدلية / الصيدلة الأكلينيكية
تخصص البحث : الصيدلة الأكلينيكية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ أسامة أيوب يعقوب - مؤلف رئيسي
الصيدلة الإكلينيكية
Objective, This study aims to assess the impact of petroleum exposure on certain biochemical parameters; to find out the sensitive predicting biomarkers which may be considered of a clinical role in detecting the toxic effect of exposure as well as to conclude the possible correlation among the parameters.Methods, 150 individuals were enrolled in this study. The participants were separated into three groups: group 1 is a control group of 50 people; Group2 is 50 people (who were oil well workers); and Group3 is 50 people (the individuals who live close to oil wells), working in the Middle Refinery Company unit for more than two years. The hematological parameters, serum interleukin 6, serum vitamin D3, serum homocysteine, and serum glutathione were all measured. Results showed significant increases in white blood cells,and platelets in Group2 and Group3 compared to Group1as well as a significant decrease of hemoglobin, hematocrit, and glutathione in workers compared to control groups. Interestingly, we found significant increases in serum interleukin 6 and homocysteine in workers. Conclusions, The individuals who work or live close to oil wells showed significant alterations in some hematological, immunological, and inflammatory parameters,as well as they, revealed more production of reactive oxygen species referring to an increase in oxidative stress.
CARDIOVASCULAR TOXICITY OF CHLORPYRIFOS IN FEMALE ADULT RATS: A PROBABLE PROTECTIVE EFFECT OF PHYTOCHEMICAL ISOFLAVONES / السمية القلبية الوعائية للكلوربيريفوس في إناث الجرذان البالغة: تأثير وقائي محتمل للأيزوفلافونات
قطاع الدراسات الصيدلية / الفارماكولوجى
تخصص البحث : الفارماكولوجى
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 8
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ اسيا سلمان عبدالله - مؤلف رئيسي
الفارماكولوجى
Chlorpyrifos (CF) an organophosphate insecticide broadly used for pest control and sterilization in agriculture applications. It has also established that CF toxicity linked to the increase of oxidative stress with accumulation of the lipid peroxides. CF poisoning causes the heart tissue to produce high quantity of free radicals, become sensitive to oxidative stress, and damage. Studies indicated that soy contains plenty of isoflavones, mainly genistein (GS), which have antioxidant properties. Current study designed to examine whether GS, daidzein (DZ), or their combination had any protection against CF induced cardiac toxicity in rats. Thirty adult female rats divided into five groups. group 1 received corn oil. group 2 received CF 6.7 mg/kg. group 3 received 6.7 mg/kg CF + 21.7 mg/kg GS. group 4 received 6.7mg/kg CF + 17.4mg/kg DZ. group 5 received 6.7mg/kg CF + 21.7 mg/kg GS + 17.4 mg/kg DZ daily oral doses for six weeks. At the end, rats sacrificed and their blood samples and heart tissues collected for biochemical and histopathology analysis. Conclusion: administration of GS or DZ provides a protective effect against oxidative stress induced by CF. However, administration of GS and DZ together synergise oxidative stress induced by CF.
STUDY THE PROTECTIVE EFFECT OF VITAMIN E AGAINST POTASSIUM BROMATE TOXICITY ON SOME HEMATOLOGICAL, RENAL, AND HEPATIC FUNCTIONS IN MALE RATS / دراسة التأثير الوقائي لفيتامين (ه) ضد سمية برومات البوتاسيوم علي بعض وظائف الدم والكلي والكبد في ذكور الجرذان
قطاع الدراسات الصيدلية / الفارماكولوجى
تخصص البحث : الفارماكولوجى
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ إيناس صالح عبد الباقي - مؤلف رئيسي
الفارماكولوجى
The current investigation was carried out to study the protective effect of vitamin E (VE) on the associated disturbances of hematological, renal, and hepatic functions in male rats produced in potassium bromate (KBrO3) treated rats. Twenty-four rats were divided randomly into four groups: First group: served as control group. Second group: rats were received 50 mg/kg b.wt. of KBrO3 orally. Third group: rats were received 30 mg/kg b.wt. of VE orally. Fourth group: rats were received 30 mg/kg b.wt. of VE orally an hour before administration of KBrO3 (50 mg/kg b.wt.) orally. The experiment continued for five successive weeks. Results showed that the treatment with KBrO3 revealed a significantly decrease in the mean of the body weight, red blood corpuscles (RBCs), white blood cells (WBCs), blood platelets (PLTs), hemoglobin (HB), hematocrit value (HCT) comparing to the control group. Whereas, the serum activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) enzymes, urea, uric acid, creatinine, were obviously elevated in KBrO3 treated group comparing with control group. The treatment with VE+KBrO3 ameliorated all the hematological, renal, and hepatic parameters tested. It is clear from the present results that VE reduced the severity of KBrO3. This could be mediated by its potent antioxidant effects.
STUDY THE PROPHYLACTIC EFFECTS OF MELATONIN AND CYANOCOBALAMIN AGAINST CYCLOPHOSPHAMIDE-INDUCED CARDIOTOXICITY / دراسة الاثار الوقائية للميلاتونين والسيانوكوبالامين ضد السمية القلبية التي يسببها سيكلوفوسفامايد
قطاع الدراسات الصيدلية / الفارماكولوجى
تخصص البحث : الفارماكولوجى
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 9
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ وليد خالد غانم - مؤلف رئيسي
الفارماكولوجى
English Cyclophosphamide chemotherapeutic agent, it’s used associated with multiorgan toxicity including the heart. Melatonin and cyanocobalamin possess cardiac-protective properties. This study was designed to evaluate the prophylactic effects of melatonin and cyanocobalamin. Fifty adult male rats have used in the study, divided into five groups each containing ten rats, melatonin, and cyanocobalamin were given orally for seven consecutive days before injection of (150 mg/kg) of cyclophosphamide on day seven. group I: Control group, in which rats were intraperitoneally injected with (1 ml/kg/day) of normal saline. group II: Rats were intraperitoneally injected with a single dose of cyclophosphamide. group III: Rats were given orally melatonin at a dose (1 mg/kg/day) and cyclophosphamide. group IV: Rats were given orally cyanocobalamin at a dose (0.1 mg/kg/day) and cyclophosphamide. group V: Rats were administered orally a mixture of melatonin at a dose (1 mg/kg/day) and cyanocobalamin at a dose (0.1 mg/kg/day) and cyclophosphamide. On day eight rats were sacrificed, serum and heart extracted for malondialdehyde, interleukin-1 beta, and troponin I measurement, furthermore cardiac immunohistochemical study was performed. It was found that both melatonin and cyanocobalamin significantly (P<0.05) decrease serum levels of malondialdehyde, interleukin-1 beta, and troponin I in comparison with group II and improve immunohistochemical changes in cardiac tissue when compared with the group treated by cyclophosphamide only (group II).
COMBINED ORAL CONTRACEPTIVE (ETHINYLESTRADIOL/ LEVONORGESTREL) ALLEVIATES LIPID AND LACTATE ALTERATIONS IN PLASMODIUM BERGHEI-INFECTED MICE / موانع الحمل الفموية المشتركة (إيثينيل إستراديول / ليفونورجيستريل) تخفف من تغيرات الدهون واللاكتات في الفئران المصابة بالبلازموديوم برجى
قطاع الدراسات الصيدلية / الفارماكولوجى
تخصص البحث : الفارماكولوجى
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 10
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ آدم عليتان عبد الكريم - مؤلف رئيسي
الفارماكولوجى
Despite the common use of combined oral contraceptive (COC) as a childbirth control pill, there is no sufficient information on the effect of COC in malaria. Hence, we aimed at investigating the effect of COC on parasite growth and the associated risk of metabolic disorder in Plasmodium berghei-infected mice. Twenty female mice were randomly allotted into four groups (n= 5/group): uninfected, infected (inoculated with P. berghei), COC (1.0 ?g ethinylestradiol and 5.0 ?g levonorgestrel, p.o/day, without infection) and infected + COC. Percentage parasitaemia was recorded weekly. At the end of 21-day exposure, the mice were sacrificed, while blood and liver were collected for biochemical analyses. Our data showed progressive increase in parasitaemia in P. berghei-infected mice. Our findings also revealed that P. berghei infection did not affect serum levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and total cholesterol (TC). It, however, elevated serum malondialdehyde (MDA), serum and liver triglycerides and liver TC. Elevations of serum and liver free fatty acid and lactate were also observed in P. berghei-infected mice. However, COC treatment lowered MDA level and attenuated lipid and lactate alterations in P. berghei infection. This study, therefore, suggests that COC possesses anti-plasmodial potential to mitigate malaria-associated metabolic disturbances. Further animal and human studies are necessary to validate our findings.
PREVALENCE OF CYP2D6*4 AND ITS POSSIBLE RELATION TO THERAPEUTIC OUTCOMES OF ADJUVANT TAMOXIFEN THERAPY IN EGYPTIAN PREMENOPAUSAL WOMEN WITH BREAST CANCER / انتشار انزيم سيتوكروم 2 دي 6*4 وعلاقته المحتملة بالنتائج العلاجية لعقار التاموكسيفين المساعد لدى النساء المصريات المصابات بسرطان الثدي في مرحلة قبل انقطاع الطمث
قطاع الدراسات الصيدلية / الفارماكولوجى
تخصص البحث : الفارماكولوجى
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 17
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ أميرة فوزي طه - مؤلف رئيسي
الفارماكولوجى
Background: Although tamoxifen is a main adjuvant therapy in estrogen positive breast cancer especially in premenopausal women, reliance on genetic polymorphisms of its CYP2D6 metabolizing enzyme and/or therapeutic drug monitoring of its active metabolite, endoxifen to determine tamoxifen-therapeutic outcomes is debatable. Objective: The goal of the study was to investigate the prevalence of CYP2D6*4 and possible association between its nonfunctional allele (A) and both tamoxifen-induced adverse effects and cancer relapse in premenopausal breast cancer patients. Method:Polymerase chain reaction -restriction fragment length polymorphism (PCR-RFLP) analysis was applied for detection of CYP2D6*4 (1846 G>A) genotypes. Results:Genotyping analysis of CYP2D6*4 showed a minimal allele frequency of 23%. Increased endometrial thickness in mm was significantly correlated with CYP2D6*4 GA and AA genotypes in comparison with GG genotypes (P< 0.01). No other relations were found between CYP2D6*4 alleles and other tamoxifen adverse effects (P > 0.9) or cancer relapse (P= 0.7). Conclusion: The prevalence of CYP2D6*4 polymorphism in Egyptian premenopausal females with breast cancer who are given tamoxifen is similar to that in Caucasians. The nonfunctional allele (A-allele) of CYP2D6*4 showed a significant association with increased endometrial thickness possibly related to tamoxifen, but no association with other drug adverse effects or cancer relapse.
ASSESSMENT OF GENITAL AND URINARY TRACT INFECTIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS TREATED WITH DAPAGLIFLOZIN / تقييم الإنتانات التناسلية والبولية لدى مرضى السكري من النمط الثاني المعالجين بالداباجليفلوزين
قطاع الدراسات الصيدلية / الفارماكولوجى
تخصص البحث : الفارماكولوجى
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 13
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ نسرين قدار - مؤلف رئيسي
الفارماكولوجى
Several studies have shown that pharmacologically induced glucosuria with dapagliflozin increases the risk of developing urinary and genital tract infections (UTIs). The aim of this study is to assess the incidence of urinary and genital infections and to investigate risk factors in T2DM patients treated with dapagliflozin 5 and 10 mg. The study included 108 patients with type 2 diabetes, aged between 40-70 years, randomly selected from the outpatient of the Endocrinology Department at Tishreen University Hospital in Syria. 52 patients received once daily dapagliflozin (5 or 10 mg) as add-on therapy to oral antihyperglycemic drugs, and 56 patients treated with antihyperglycemic agents for 24 weeks. We compared patients with well-controlled diabetes to deny the effect of HbA1c on the incidence of urinary and genital infections. We observed that treatment with dapagliflozin is associated with an increased risk of developing genital infections. There was no statistically significant increase in the incidence of urinary infections in patients treated with dapagliflozin. We identified gender and a previous history of genital infection as risk factors for genital infection. Long-term studies are still needed to determine association of dapagliflozin with an increased risk of UTIs.
LETROZOLE SUPPRESSES HEPATIC OXIDATIVE STRESS AND AMELIORATES LIPID ACCUMULATION IN FRUCTOSE-EXPOSED WISTER RATS / عقار ليتروزول يقلل الإجهاد التأكسدي الكبدي ويخفف من تراكم الدهون في جرذان ويستر المعرضة للفركتوز
قطاع الدراسات الصيدلية / الفارماكولوجى
تخصص البحث : الفارماكولوجى
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 8
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ آدم عليتان عبد الكريم - مؤلف رئيسي
الفارماكولوجى
An increase in sugar intake, especially fructose or fructose-containing sweeteners, poses a serious public health challenge globally. Unlike glucose, fructose metabolism results in generation of oxidative stress, which promotes hepatic lipid accumulation and consequently increases the risk of non-alcoholic fatty liver disease (NAFLD). chronic administration of letrozole has been previously reported to decrease lipid peroxidation and increase antioxidants but its effect on fructose-induced lipid accumulation has not been investigated. Thus, the present study sought to investigate the ameliorative effect of letrozole on hepatic oxidative stress and lipid accumulation in high fructose-taking Wister rats. After 3-week of exposure, our results reveal that fructose intake increased hepatic total cholesterol (p< 0.01), triglycerides (p< 0.001) and free fatty acid (p< 0.001). Similarly, fructose increased hepatic malondialdehyde (MDA) (p< 0.001 vs. control) and decreased catalase and superoxide dismutase activities (p< 0.001 and p < 0.05 vs. control, respectively). Furthermore, our data show that high fructose intake elevated levels of uric acid and xanthine oxidase activity in the liver (p< 0.001 vs. control). However, letrozole treatment attenuated the hepatic lipid accumulation, reduced MDA level, and suppressed uric acid biosynthesis in high fructose-taking rats. Conclusively, this study has demonstrated that high fructose intake induces hepatic uric acid synthesis, generating oxidative stress and promoting hepatic lipid accumulation in male Wister rats, while administration of letrozole attenuates the fructose effects. Our findings, therefore, suggest the efficacy of letrozole in attenuating hepatic lipid accumulation, hence, lowering the risk of NAFLD associated with excessive fructose intake.
POTENTIAL PROTECTIVE EFFECT OF METFORMIN AND L-CARNITINE IN RAT MODEL OF CARBOPLATIN-INDUCED MYELOSUPPRESSION, COMPARATIVE STUDY / التأثير الوقائي المحتمل لميتفورمين وإل كارنيتين في نموذج الفئران لتثبيط النخاع الناجم عن كاربوبلاتين ، دراسة مقارنة
قطاع الدراسات الصيدلية / الفارماكولوجى
تخصص البحث : الفارماكولوجى
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 14
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ رانيا شلبى - مؤلف رئيسي
الفارماكولوجى
Background: Carboplatin (CP), a well-known second-generation platinum compound, is effective against various malignancies including ovarian, lung, neck, breast, cervix and bladder cancer. However, myelosuppression is the most overwhelming toxic effect which results in leucopenia, thrombocytopenia and anemia. L-Carnitine (LCR) is a well-known antioxidant, cardioprotective, neuroprotective, and immunostimulant natural chemical compound. Metformin (MF) is a well-known drug approved for type 2 DM treatment. The aim of this work was to compare the potential protective effect of metformin and L-carnitine in a rat model of CP-induced myelosuppression. Methods and results: This study was performed on 40 adult male albino rats which were divided into four groups: control group, Carboplatin (CP) group, metformin (MF+CP) group and L-Carnitine (LCR+CP) group. Serum was used for measurement of TNF-? alpha, malondialdehyde (MDA), glutathione peroxidase (Gpx), glutathione reductase, catalase and superoxide dismutase (SOD) levels. Histopathological and immunohistochemical changes analyses were done in bone marrow. Carboplatin group showed redox status imbalance which was reversed by metformin and l-carnitine treatment corrected redox status balance. RBCs, WBCs and platelets counts were decreased in carboplatin treated group. Metformin and l-carnitine increased RBCs, WBCs and platelets counts significantly. TGF-?1 and caspase 3 expression were high in carboplatin treated group. Metformin and l-carnitine treatment significantly decreased their expression. Conclusions: Metformin and L-Carnitine have a possible protective role in myelosuppression induced by carboplatin and this effect is more potent with LCR treatment so we could recommend using L-Carnitine during Carboplatin treatment to prevent developing myelosuppression.
DEXAMETHASONE-INDUCED METABOLIC SYNDROME: RE-EVALUATION OF AN UNDERESTIMATED EXPERIMENTAL MODEL / متلازمة الأيض المستحثة بالديكساميثازون: إعادة تقييم نموذج تجريبي مقلل من شأنه
قطاع الدراسات الصيدلية / الفارماكولوجى
تخصص البحث : الفارماكولوجى
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 16
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ محمد معتصم محمد عسكر - مؤلف رئيسي
الفارماكولوجى
Dexamethasone is a fluorinated steroid and a synthetic member of glucocorticoids. It is an approved medication for inflammatory and allergic disorders. Also, it is clinically used in high doses to manage pain associated with metastatic osteolytic lesions. Furthermore, it has a wide array of side effects, particularly at high doses and after prolonged consumption, like; hypertension, hyperglycemia, and dyslipidemia. It is a promising tool for studying the underlying mechanisms of metabolic syndrome and insulin resistance. This review article discusses metabolic syndrome and insulin signaling. In addition, this review article will discuss metabolic-dexamethasone effects on the skeletal muscle, liver, adipose tissue, pancreas, brain, and the cardiovascular system, its underlying mechanisms of action, and the benefits of use, in comparison to the other dietary and chemical models of insulin resistance and type 2 diabetes, to identify new potential pharmacological treatments of the metabolic syndrome and its related complications.
EFFICACY OF OLMESARTAN, IRBESARTAN AND TELMISARTAN AGAINST ACUTE INDOMETHACIN-INDUCED GASTRIC ULCERS IN MICE / تقييم فعاليّة الأولميسارتان، الإربيسارتان، والتيلميسارتان ضدّ قرحات المعدة الحادّة المُحدثة بالإندوميتاسين لدى الفئران البحث
قطاع الدراسات الصيدلية / الفارماكولوجى
تخصص البحث : الفارماكولوجى
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 8
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ سارة خلوف - مؤلف رئيسي
الفارماكولوجى
Recent studies have determined detrimental effects of angiotensin-II in gastric mucosa. This study aims to investigate the gastroprotective role of some Angiotensin-II receptor blockers (ARBs): olmesartan, irbesartan and telmisartan on indomethacin-induced gastric ulcers in mice. Also, it provides a new comparison to know if the agonist action of peroxisome proliferator-activated receptor gamma (PPAR-?) involves in protecting gastric mucosa; if found. Animals were divided into six groups (n= 9 in each); group 1 (normal control), group 2 (non-pretreated, induced-ulcer), group 3 (olmesartan 8.2 mg/kg), group 4 (irbesartan 61.5 mg/kg), group 5 (telmisartan 16.4 mg/kg), group 6 (ranitidine 61.5 mg/kg). Drugs were given orally for 15 days; then gastric ulcers were induced by a single oral dose of indomethacin (250 mg/kg). Histological findings showed that these members of ARBs decreased the depth of ulcers but without significant difference between them. Their gastroprotective effects were not comparable to ranitidine effect. We need further researches, and recommend studying the effect of ARBs in combination with anti-ulcer drugs.
THE POTENTIAL MODULATING IMPACT OF THE DIPEPTIDYL PEPTIDASE-4 (DPP-4) INHIBITOR, SITAGLIPTIN ON STREPTOZOTOCIN-NICOTINAMIDE-INDUCED DIABETIC NEPHROPATHY IN RATS / التأثير المعدل المحتمل لمثبط الداي بيبتيديل بيبتيداز-4، سيتاجلبتن على اعتلال الكلية السكري الناجم عن الستربتوزوتوسين-نيكوتيناميد في الفئران
قطاع الدراسات الصيدلية / الفارماكولوجى
تخصص البحث : الفارماكولوجى
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 14
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ رانيا عبد المنعم عبد الامام - مؤلف رئيسي
الفارماكولوجى
The main risk factor for the onset and development of diabetic nephropathy (DN) is hyperglycemia. Kidney end-stage disease is brought on by DN, a significant microvascular consequence of diabetes. In this study, we evaluated the renoprotective potential of sitagliptin in a rat model of streptozotocin-nicotinamide-induced DN. Following the intraperitoneal treatment of rats with 110 mg/kg nicotinamide followed 15 min by 60 mg/kg streptozotocin, DN manifested in rats after 8 weeks. Fasting blood glucose, postprandial blood glucose, HbA1c, serum urea and creatinine, and urine albumin levels were assessed in control, DN, and DN rats treated with sitagliptin. Additionally, paraffin-embedded kidney segment histopathological assessment was carried out. The increased levels of fasting, postprandial blood glucose, and HbA1c were decreased with sitagliptin. Sitagliptin restored the changes in kidney structure and function brought on by DN. The findings suggest that sitagliptin could prevent DN by stringent glycemic management, restoring the kidneys’ declining function and protecting their structure.
AN OVERVIEW OF INCRETIN-BASED THERAPIES: PHARMACOLOGY AND FUTURE PERSPECTIVES / نظرة عامة على العلاجات القائمة على الإنكريتين: علم الأدوية ووجهات النظر المستقبلية
قطاع الدراسات الصيدلية / الفارماكولوجى
تخصص البحث : الفارماكولوجى
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 16
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ جيهان حسين هيبة - مؤلف رئيسي
الفارماكولوجى
Glucagon-like peptide-1 (GLP-1) is a gut-derived incretin hormone that is released upon nutrient ingestion stimulating insulin secretion, suppressing glucagon secretion, and suppressing appetite and food intake which contribute to glucose homeostasis. The incretin system is impaired during type 2 diabetes mellitus (T2DM). Incretin-based therapies are gaining popularity in the clinical field nowadays. Current treatment guidelines for T2DM incorporate glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase 4 inhibitors (DPP-4i) as second-line agents with the advantages of low risk of hypoglycemia with good control of postprandial hyperglycemia (with short-acting GLP-1 RAs and DPP-4i) and weight loss (with GLP-1 RAs). GLP-1 RAs have more efficacy and are preferred with patients with preexisting cardiovascular disease. Growing evidence suggests that incretin-based therapies have beneficial effects on cardiovascular, liver, kidney, and nervous system disorders. The current review includes the biology of the incretin system, the pharmacology of incretin-based therapies, and their applications in experimental and clinical work.
PREVALENCE OF ALLOIMMUNIZATION AGAINST RED BLOOD CELLS ANTIGENS IN SICKLE CELL DISEASE PATIENTS IN LATAKIA, SYRIA / شيوع الأضداد المناعية تجاه مستضدات الكريات الحمر لدى مرضى فقر الدم المنجلي في اللاذقية
قطاع الدراسات الصيدلية / الكيمياء الحيوية
تخصص البحث : الكيمياء الحيوية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 10/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 8
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ سراء بدور - مؤلف رئيسي
الكيمياء الحيوية
Sickle cell disease (SCD) is one of the most common inherited hemoglobin disorders in most parts of the world, including Syria. Red blood cells transfusion is a supportive procedure for patients with SCD. However, repeated blood transfusion is not risk-free; one major complication is RBCs alloimmunization; which is the focus of this study. Our objective was to estimate the prevalence of alloimmunization against RBCs antigens in multi-transfused SCD patients in the coastal city of Latakia, Syria, and to identify the involved alloantibodies. The factors that might affect RBC alloimmunization in these patients will also be studied. A multicenter study was carried on 100 SCD patients who previously received blood transfusions, and medical records of these patients were consulted. Antibody screening and identification were done using indirect antiglobulin test (IAT) at 37?C in gel cards. Extended antigens phenotyping, autocontrols, and direct Coombs test (DAT) were also performed. In this first study in our region, we found that 10% of SCD patients developed clinically significant alloantibodies. None of the patients enrolled in our study had autoantibodies. Of 10 cases of alloimmunization, the alloantibodies we identified were: anti-c (3/10), anti-K alone (2/10), anti-E (1/10), anti-Fya (1/10), anti-D alone (1/10), anti-C with anti-D (1/10), anti-C with anti-K (1/10). Matching for Rh and Kell antigens will significantly decrease alloimmunization rate, since it may prevent the development around 90% of RBCs alloantibodies in a Syrian population of multi-transfused SCD patients.
EVALUATION OF SERUM ZINC LEVELS AND ITS RELATIONSHIP TO GLYCEMIC CONTROL AND LIPID PROFILE IN TYPE (2) DIABETES MELLITUS / تقييم المستويات المصلية للزنك وعلاقته مع ضبط سكر الدم والصيغة اللبيدية لدى مرضى الداء السكري من النمط الثاني
قطاع الدراسات الصيدلية / الكيمياء الحيوية
تخصص البحث : الكيمياء الحيوية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 11/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ ريمال أسعد - مؤلف رئيسي
الكيمياء الحيوية
Due to the importance of Zinc in glucose and lipid metabolism, it has been aimed in this study to investigate the association of serum zinc levels with glycemic control and lipid profile in type 2 diabetes mellitus patients (T2DM). This study has been conducted on 129 adult patients with diabetes at Tishreen University Hospital (TUH) and The Diabetes Center of Latakia City in Syria, and 51 matched healthy subjects. The results have shown a statistically significant decrease in serum zinc levels in T2DM patients compared with controls. A statistically significant negative correlation has been identified between zinc and all of HbA1C, BMI, duration of disease, and triglycerides, while a positive correlation has been observed with HDL levels in the diabetic group. In conclusion, this study has demonstrated that low zinc level is associated with poor glycemic control and it may give a cause to explain a possible association with dyslipidemia observed in T2DM patients.
PHARMACOLOGICAL EVALUATION OF NOOTROPIC AND NEUROPROTECTIVE ACTIVITY OF SESBANIA GRANDIFLORA EXTRACTS IN STREPTOZOTOCIN-INDUCED DIABETIC MODEL OF RATS / التقييم الدوائي لنشاط منشط الذهن والوقاية العصبية لمستخلصات نباتات سيسينيا جرانديفلورا في نموذج الجرذان المصابة بمرض السكري الناجم عن الستربتوزوتوسين
قطاع الدراسات الصيدلية / الكيمياء الحيوية
تخصص البحث : الكيمياء الحيوية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 11/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 14
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ راشاسخار ردي الافالا - مؤلف رئيسي
الكيمياء الحيوية
Background: Diabetes Mellitus (DM) is a multifactorial disorder and is frequently correlated with chronic problems associated with various major organs. In recent times, there has been some correlations reported about the neurological complications of DM, such as cognitive impairment, vascular dementia, stroke, or depression. and observed that the brain tissue of the diabetic patients with hyperglycemia have shown injury at various locations with a varied profile of micro and macrostructural changes, which leads to the neurodegeneration, neuro-vascular deterioration, neuro-inflammation, and progressive cognition decline. Aim: The current study assesses memory enhancing activity of Sesbania grandiflora (SG) extracts in streptozotocin (STZ)-induced diabetic model in rat. Methods: The extracts (petroleum ether, ethyl acetate and methanol) were analyzed for acute toxicity and later its neuroprotective and memory enhancing activity in the selected rat model. STZ (55 mg/kg) injection was administered intraperitoneally to the animals to induce memory impairment. SG extracts were administered for 70 days after confirming STZ-induced dementia to detect its beneficial effect. To know the memory function the animals were subjected to Y-maze and Morris water maze test. After the tests, the animals were sacrificed and performed cholinergic function and oxidative stress with the brain tissue. Results: It was observed that STZ caused significant memory impairment, which was significantly reversed by methanolic extract with 100 and 200 mg/kg. It was found that the cholinergic dysfunction, rise in lipid peroxidation levels were significantly (p<0.001) reduced. In the diabetic induced group, it was identified that there was a radical reduction of glutathione, superoxide dismutase, and catalase activities than the control group animals. Conclusion: The current investigation established that SG leaf extracts improve the memory by enhancing the cholinergic transmission and reducing the oxidative stress in the brain of diabetic rats.
IN SILICO DESIGN AND VALIDATION OF A NOVEL PCR-RFLP ASSAY FOR GPRC6A RS2247911 POLYMORPHISM INVOLVED IN MALE INFERTILITY / تصميم دراسة مجراة حاسوبياً واختبار المصدوقية لمقايسة جديدة للتحري عن التعدد الشكلي rs2247911 في جين GPRC6A المتورط في العقم الذكري
قطاع الدراسات الصيدلية / الكيمياء الحيوية
تخصص البحث : الكيمياء الحيوية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 11/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 8
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ كندة جاويش - مؤلف رئيسي
الكيمياء الحيوية
Male infertility is a prevalent disorder affecting approximately 7% of the male population, at least 2,000 genes are involved in spermatogenesis, availability of genetic investigations is a challenge in developing countries, GPRC6A, G-protein coupled receptor, activated by Osteocalcin (OCN)an osteoblast secreted hormone, is a master regulator of a complex metabolic and reproductive networks. rs2247911 in GPRC6A plays a role in male fertility and glucose metabolism, Although DNA sequencing is regarded the golden standard tool for genotyping, it is less affordable in developing world laboratories, polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) assay is an inexpensive and highly valuable tool for genotyping, this study aimed to develop (PCR-RFLP) method for assessment of rs2247911 polymorphism.10% of male subjects genotyped previously by sequencing were genotyped the by PCR-RFLP method based on Geneious® bioinformatics tool suggested restriction enzyme (ScrFI), PCR-RFLP 100% correctly identified genotypes. we present for the first time an accurate and inexpensive method for genotyping rs2247911.
IL-17F GENE POLYMORPHISM (7488T/C, RS763780) IN EGYPTIAN PATIENTS WITH SLE / التعد الجينى للانتليوكين السابع عشرF- فى المرضى المصريين المصابين بالزئبة الحمراء
قطاع الدراسات الصيدلية / الكيمياء الحيوية
تخصص البحث : الكيمياء الحيوية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 11/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 12
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ ماجد مصطفى - مؤلف رئيسي
الكيمياء الحيوية
Systemic Lupus erythematosus (SLE) is a worldwide autoimmune disease with different presentations. Genetic and environmental factors like infection and ultraviolet light are supposed to be responsible for the development of SLE. Disturbance in cytokines production may be involved in SLE pathogenesis. In this case-control study, we investigate the interleukin-17F (IL-17F) gene polymorphism (7488T/C, rs763780) in Egyptian SLE patients using polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP). There were no significant changes when both genotypes and alleles for patients and controls were compared with each other. According to the results, no association between the IL-17F gene polymorphism (7488T/C, rs763780) and SLE.
EVALUATION OF ADIPOSITY PHENOTYPES: LIPID ACCUMULATION PRODUCT INDEX, VISCERAL ADIPOSE INDEX AND BODY ROUNDNESS INDEX AS PREDICTOR MARKERS FOR METABOLIC SYNDROME DEVELOPMENT IN TYPE 2 DIABETES MELLITUS / تقييم واسمات النسيج الشحمي:مشعر تراكم المنتجات الشحمية, مشعر الشحوم الحشوية، ومشعر محيط الجسم كعوامل تنبؤية للإصابة بالمتلازمة الاستقلابية لدى مرضى الداء السكري النمط الثاني
قطاع الدراسات الصيدلية / الكيمياء الحيوية
تخصص البحث : الكيمياء الحيوية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 11/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ رمال عبد العزيز أسعد - مؤلف رئيسي
الكيمياء الحيوية
Visceral obesity is strongly associated with Metabolic syndrome (MetS) and increases the risk of cardiovascular disease in type II diabetes mellitus (T2DM). We aimed in this study to determine the best discriminator of obesity indexes to predict the occurrence of MetS in T2DM patients. The present study was conducted on 129 T2DM patients (Mets+: 70.54% & MetS-: 29.45%) during the period from 2020 to 2021. MetS+ patients have higher HbA1C, TG, and obesity indexes (BMI, WC, BF%, BRI, VAI, LAP) compared with MetS- group with a lower HDL-cholesterol in the MetS+ group. The average of BF%, VAI, and LAP increased with increasing the number of MetS components according to NCEP-ATPIII criteria. In addition, the optimal cutoff points for obesity indexes were determined. Therefore, LAP with cutoff: 46.48 (AUC: 0.774, sensitivity: 80.2%, and specificity: 62.5%), VAI with cutoff: 1.73 (AUC: 0.668, sensitivity: 71.4%, and specificity: 54.2% ), and BRI with cutoff: 5.22 (AUC: 0.774, sensitivity: 82.4%, and specificity: 58.3%) seemed to be as useful indexes in MetS prediction among T2DM patients.
INTERFERON LAMBDA-3 AS A NEW CANDIDATE GENE INVOLVED IN THE PROGRESSION OF IDIOPATHIC PULMONARY FIBROSIS / جين إنترفيرون لامدا-3 مرشح جديد مشارك في تطور التليف الرئوي مجهول السبب
قطاع الدراسات الصيدلية / الكيمياء الحيوية
تخصص البحث : الكيمياء الحيوية
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 11/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ خالد ثابت - مؤلف رئيسي
الكيمياء الحيوية
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial respiratory illness with an unknown origin, which leads to inevitably fatal outcomes in the majority of cases. The pro-inflammatory cytokine interferon lambda-3 (IFN-?3) has been recently identified as a risk factor for the development of lung fibrosis in scleroderma patients. In this study, we examined the involvement of IFN-?3 in IPF by utilizing the mouse model of BLM-induced pulmonary fibrosis. Our study identifies a remarkable overexpression in the mRNA of IFNL3, and a positive significant correlation between the IFNL3 mRNA levels and the various pro-inflammatory cytokines for instance NF-kB, TNF-?, IL-1? and TGF-? throughout the three-weeks study. These findings have proven the impact of IFNL3 on BLM-induced pulmonary fibrosis occurrence and progression. Moreover, the data suggest that the pro-inflammatory and pro-fibrotic capacities of IFNL3 may be provoked by additional pro-inflammatory cytokines NF-kB, TNF-?, IL-1?, and TGF-?. In conclusion, IFN-?3 looks like a promising target in the therapeutic development of new drug candidates for pulmonary fibrosis.
NANOPARTICLES BASED COMBINED ANTIMICROBIAL DRUG DELIVERY SYSTEM AS A SOLUTION FOR BACTERIAL RESISTANCE / نظام توصيل مزيج المضادات الحيوية المعتمد على جسيمات النانو و ذلك للحد من مقاومة البكتيريا
قطاع الدراسات الصيدلية / الميكروبيولوجيا الطبية والمناعة
تخصص البحث : الميكروبيولوجيا الطبية والمناعة
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 11/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 21
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ صافى هديه - مؤلف رئيسي
الميكروبيولوجيا
The absence of novel antimicrobials is a main cause of the emergence of antibiotic resistance. Antimicrobial resistance has been evolved because of a variety of methods such as enzyme inactivation, reduced cell permeability, target mutation, changed target site/enzyme, and efflux pump overexpression. Using a combination of two antimicrobials drugs lead to an increase of the spectrum of antibiotics against multi drug resistance bacteria and a decrease in the emergence of resistant mutants. Despite of several advantages of using a combination of antibiotics, resistance can develop during treatment. Encapsulation of antimicrobials within the nanoparticles was proven to reduce the antimicrobial resistance by increasing the intracellular bioavailability of antimicrobial drugs through decreasing the development of resistant mutants and inhibiting the efflux pump. In this review, we will summarize the antimicrobial resistance, use of combined therapy and the use of antimicrobials- loaded nanoparticles and their application in the future to fight multidrug resistant bacteria.
EVALUATION OF THE SAFETY AND RESISTANCE ASSOCIATED VARIANTS OF SOFOSBUVIR/DACLATASVIR AMONG EGYPTIAN PATIENTS WITH HEPATITIS C VIRUS: A PROSPECTIVE STUDY / تقييم سلامة عقاري السوفوسبيوفير والدكلاتاسفير والطفرات المقاومة بين المرضي المصريين المصابين بالالتهاب الكبدي الفيروسي (سي): دراسة مستقبلية
قطاع الدراسات الصيدلية / الميكروبيولوجيا الطبية والمناعة
تخصص البحث : الميكروبيولوجيا الطبية والمناعة
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 11/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ هلال ف. حتة - مؤلف رئيسي
الميكروبيولوجيا
Background: Hepatitis C virus (HCV) is a major health problem. Current treatment by direct-acting antivirals achieved high sustained virological response (SVR). However, drug intolerance or relapse may occur. We aimed to demonstrate the safety of sofosbuvir (SOF) plus daclatasvir (DCV) regimen in Egyptian patients with hepatitis C infection and the assessment of resistance associated variants (RAVs) in non-responders. Methods: In this prospective study, 850 HCV patients eligible to SOF + DCV ± ribavirin (RBV) were recruited. They were divided into two groups; patients with chronic hepatitis C (CHC) and patients with liver cirrhosis. Baseline data included clinical history, examination, routine laboratory tests and HCV viral load. Safety evaluation was assessed during treatment up to 12 weeks after the end of treatment. RAVs assessment was considered at baseline and in cases of relapse. Results: CHC group included 548 patients while 302 had liver cirrhosis. The most frequent adverse events were headache 20%, fatigue 14%, myalgia 5.2%. Diarrhea occurred in 4.6% with significantly higher frequency among liver cirrhosis group; 7.3% vs. 3.1% (P= 0.04). No patients had to stop treatment because of adverse events. SVR was achieved in 91.2% while 75 (8.8%) had relapse. At baseline, RAVs were found in 10%. After therapy, RAVs (E237D) were detected in 1 non-responder. Conclusion: Treatment with SOF/DCV was effective and well tolerated in patients with HCV. RAVs testing is not routinely recommended before treatment as resistant variants could occur naturally in HCV.
EVALUATION OF PRESERVATIVE EFFECTIVENESS IN SOME EYE DROPS IN SYRIAN MARKET BY ANTIMICROBIAL EFFECTIVENESS TEST ACCORDING TO DIFFERENT PHARMACOPEIAS / تقييم فعّاليّة المادّة الحافظة في بعض القطورات العينيّة المسوّقة في السّوق السوريّة باستخدام اختبار فعالية المادّة الحافظة وفقاً لدساتير دوائية مختلفة
قطاع الدراسات الصيدلية / الميكروبيولوجيا الطبية والمناعة
تخصص البحث : الميكروبيولوجيا الطبية والمناعة
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 11/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 9
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ ريم رجب - مؤلف رئيسي
الميكروبيولوجيا
Ophthalmic drops are subject to microbial contamination during use and storage by repeated opening of bottle when administrating individual doses, touching dropper-tip with infected eye/eyelid or contaminated hands, that why preservatives are added to eye drops packaged in multidose containers to prevent preparation spoilage and minimize hazards of ophthalmic infections ,especially in post-operative patients. The aim of this study is to evaluate and compare the effectiveness of preservatives in three commercially marketed ophthalmic drops (timolol maleate solution 0.5%, polyvinyl alcohol solution 1.4%, and prednisolone acetate suspension 1%) in Syrian market by compendial antimicrobial effectiveness test which is not yet subject to international harmonization in different pharmacopeias. The results showed that timolol maleate ophthalmic solution 0.5%, and polyvinyl alcohol ophthalmic solution 1.4% comply with different compendial acceptance criteria in antimicrobial effectiveness test(AET) , while prednisolone acetate ophthalmic suspension 1% didn’t comply with any of compendial acceptance criteria.. There are many reasons can lead to preservative failure like adsorption of preservatives on plastic bottles and/or differences in formulation conditions of eye drops (viscosity- increasing agents , surfactants, incompatibility between product’s pH range and optimal pH range of preservative used).
LISTERIA MONOCYTOGENES: MECHANISMS OF PATHOGENESIS AND ANTIMICROBIAL RESISTANCE / Listeria monocytogenes: آليات الإمراضية ومقاومة مضادات الميكروبات
قطاع الدراسات الصيدلية / الميكروبيولوجيا الطبية والمناعة
تخصص البحث : الميكروبيولوجيا الطبية والمناعة
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 11/01/2023
تاريخ قبول البحث 24/01/2023
عدد صفحات البحث 9
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ كنعان التميمي - مؤلف رئيسي
الميكروبيولوجيا
Listeria monocytogenes is nonspore-forming, gram-positive rods, it is a widespread bacterium; it can survive for a long time in different environments such as food, soil, water, and feces causing adverse health impacts in both animals and humans. Because of its pathogenesis mechanism combined with its ubiquity, It’s considereda serious concern. Invasive listeriosis could be without symptoms until 1-4 weeks after infection. It causes serious complications especially in pregnant women, newborn babies, and people with weakened immunity if left untreated. An example of its outbreak what happened in South Africa in January 2018, which resulted in 180 deaths. Attention is conferred on L.monocytogene from being able to adapt to many types of stresses. Moreover, it can activate specific genes during the life cycle allowing it to replicate within many host cell types during its infection. In our review, we will highlight the pathogenicity of L.monocytogenes, with emphasis on its antimicrobial resistance.
IMPACT OF INFECTION WITH HELICOBACTER PYLORI ON INTERLEUKIN-10 MRNA EXPRESSION IN STOMACH MUCOSA / تأثير العدوى بالبكتيريا الملوية البوابية على التعبير الجينى للإنترلوكين 10 فى الغشاء المخاطى للمعدة
قطاع الدراسات الصيدلية / الميكروبيولوجيا الطبية والمناعة
تخصص البحث : الميكروبيولوجيا الطبية والمناعة
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 11/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ إبراهيم عبدالهادى أمين - مؤلف رئيسي
الميكروبيولوجيا
The immuno-regulatory cytokine interleukin 10 (IL-10) is important in reducing the inflammatory response during H. pylori infection. The goal of our study was to explain how H.pylori infection affects mucosal IL-10 mRNA expression. This study included seventy-three patients suffering from gastroduodenal disorders admitted to Assiut University Hospitals, (35 (47.95%) were males, and 38 (52.05%) were females). Three antral biopsies were obtained from each patient during endoscopic examination. Two invasive tests (Rapid urease test (RUT) and polymerase chain reaction (PCR)) were performed for the detection of H. pylori infection in all participants. Real time PCR (RT-PCR) was performed for determination of IL-10 mRNA expression. Results of RUT and PCR indicated that 60.27% of patients were H. pylori infected. Our results showed that patients positive for H. pylori had significantly higher IL10 mRNA expression than H. pylori-negative patients. Finally, overexpression of IL 10 during H. Pylori infection may be implicated in the downregulation of excessive immune response.
MONKEYPOX: FACTS ABOUT THE DISEASE / جدري القرود: حقائق عن المرض
قطاع الدراسات الصيدلية / الميكروبيولوجيا الطبية والمناعة
تخصص البحث : الميكروبيولوجيا الطبية والمناعة
Bulletin of Pharmaceutical sciences / / vol.45 الجزء الثانى لعام 2022 - 31/12/2022
تاريخ تقديم البحث 11/01/2023
تاريخ قبول البحث 27/01/2023
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ كنعان التميمي - مؤلف رئيسي
الميكروبيولوجيا
Monkeypox is a zoonotic disease caused by the monkeypox virus of the genus Orthopoxvirus genus and Poxiviridae family. Many animal species, including rodents and monkeys, can transmit the virus. However, the natural reservoir is unknown yet. It can be transmitted to humans via close contact with infected animal or person, or contaminated materials. Monkeypox virus was first detected in 1958 among cynomolgus monkey’s colony in Denmark. The first human case of monkeypox was reported in September 1970 in a 9-month-old child with smallpox-like vesicular skin lesions. This virus usually affects humans and animals living in Central and West Africa, yet it led to several outbreaks previously out of Africa since its discovery. Since 7 May 2022, monkeypox started to appear again in non-endemic countries. By 29 July 2022 at 9:00 PM (GMT), 22485 confirmed cases were recorded worldwide. This review focuses on monkeypox virus structure, transmission, symptoms, diagnosis methods, treatment and prevention.
جميع البيانات التي يتم تسجيلها على النظام هي ملك للجهة صاحبة هذه البيانات
لا يتم الاطلاع على هذه البيانات من قبل مهندسي المركز إلا للضرورة القصوى ولغرض الدعم الفني وبالاتفاق مع الجهة صاحبة البيانات شفوياً أو كتابياً
لا يتم إعطاء أي بيان من بيانات النظام لأي فرد او جهة فرعية تنتمي للجهة صاحبة البيانات او لأي جهة أخرى إلا بموافقة كتابية من الجهة صاحبة البيانات
يمكن استخدام البيانات المسجلة على النظام بهدف عمل إحصائيات يستفاد منها فى قياس اداء النظام وكفاءة استخدامه من قبل مستخدميه
يتم تأمين جميع البيانات الخاصة بالنظام من خلال تأمين الحاسب الخادم الذي يستضيف البيانات ومن خلال تأمين انتقال البيانات بين جهاز المستخدم والحاسب الخادم وكذلك تأمين واجهة النظام التي يستخدمها المستخدم
كل مستخدم للنظام مسئول مسئولية كاملة عن كلمة المرور الخاصة به وعليه اتخاذ كافة الاحتياطات الممكنة حتى لا يستطيع أى شخص آخر الحصول عليها
تسجيل دخول 
Download Paper
