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العنوان
The Neuroprotective Effects of Antenatal Magnesium Sulphate in Preterm Infants :
المؤلف
Abd-Elfatah, Enas El-Saeed.
هيئة الاعداد
باحث / ايناس السعيد عبد الفتاح
مشرف / هشام محمد ابراهيم الطوخي
مشرف / احمد محمود هجرس
مشرف / اسماس محمود المسيري
الموضوع
Obstetrics. Gynecology.
تاريخ النشر
2023.
عدد الصفحات
66 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض النساء والتوليد
تاريخ الإجازة
21/4/2024
مكان الإجازة
جامعة طنطا - كلية الطب - التوليد وامراض النساء
الفهرس
Only 14 pages are availabe for public view

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Abstract

This prospective observational study was carried out on 50 pregnant women at 30 through 34 weeks of gestation with imminent or early preterm labour. Patients will be classified into: • Study group: 25 cases with early preterm labour in latent phase (cervical dilatation ≤ 4 cm). • Control group: 25 cases with imminent preterm labour in active phase (cervical dilatation ≥ 6 cm). For the mother, each case was subjected to full history taking, routine lab investigations (CBC and CRP), routine radiology (US) to exclude fetal anomalies, monitor maternal pulse, blood pressure, respiratory rate, tendon reflexes and urine output for toxicity of MgSo4. After delivery: the neonate was subjected to an assessment of APGAR score at 5 and 10 minutes, clinical examination, seizures activity, routine lab investigation and cranial ultrasound and neonatal outcomes at delivery and at scheduled follow-up visits and at discharge from neonatal unit. Summary of our Results: • Regarding patient characteristics (age, weight, height, and BMI), gestational age and parity of the studied groups, there was insignificantly different between both groups. • The number of fetuses was insignificantly different between both groups. The incidence of Intra-ventricular hemorrhage (IVH) was significantly lower in the study group than control group (P value = 0.047). • APGAR score was significantly higher in study group than control group after 5 min and after 10 min (P value = 0.001 and 0.013 respectively). • APGAR was significantly lower in study group than control group at 5 min <7 and at 10 min <7 (P value = 0.011 and 0.015 respectively). • NICU admission, need for NCPAP and MV were significantly lower in case group than control group (P value 0.015, 0.024 and 0.042 respectively) • Seizures were significantly lower in the studied group than control group (P value = 0.018). Mortality was insignificantly different between both groups.