الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 96 |  |  |
| | | from | 96 | | |
Abstract
Type 1 diabetes mellitus (T1D ) may lead to severe long-term health consequences, such as renal failure, blindness, as well as heart and cerebrovascular disease. Although a direct relationship between blood glucose control and diabetes complications remains to be established beyond doubt, most diabetologists aim to achieve the best possible glucose control in their patients with T1D .assuit. (Kim et al., 2012).
Traditionally, HbA1c value has been used to measure long- term glycemic control over the preceding 2–3 months in DM patients. But recent studies have left areas of uncertainty about HbA1c: biological variability and clinical variability. Variability of Hb lifespan affects the HbA1c levels and the relationship of HbA1c monitoring to microvascular disease in T2DM is not strongly established. (Kim et al., 2012)
Alternative methods of assessment of glycemia are fructosamin and glycated albumin which assesss the degree of glycemia over a period of two to three weeks. (Rhea et al., 2013).
The present study aimed for evaluate glycated albumin to measure intermediate- term glycemic control in type 1 diabetic children in comparison with HbA1c.
This study was conducted on Twenty five patients (10 males – 15 females) with age ranging from (2-15 years) diagnosed as type 1 diabetes.They were selected consecutively attending endocrinology out patient clinic in zagazing university children’s hospital. Twenty two age and sex matched subjects were used as controls consisting of 12 females (54.4%) and 10 males (45.5%) of non diabetic children. (Kim et al., 2012).
The results was statistically analyzed and we observed the followings:
• The twenty five diabetic children were assessed by self monitoring of blood sugar and HbA1cand was divided in to two groups Patients with HbA1c above the recommended values for age by the American Diabetes Association were considered as poor glycemic control group (uncontrolled group) (76%) and controlled group (24%).
• Among uncontrolled group they have higher average blood sugar readings, higher HbA1c values and higher fructosamin than controlled group.
• Our study revealed that there was significant relationship between fasting blood glucose levels and GA among diabetic patients (r=0.547,p < 0.05) and highly significant relationship between HbA1c and GA (r=0.632,p < 0.001)
• Glycated albumin showed no significant statistical differences regarding age, sex (p=0.58,p=0.7 respectively) and BMI (p=0.784).
• In receiver operating characteristics (ROC) curve analysis,area under the curve (AUC) for glycated albumin was 88.6%.