الفهرس 
1- IntroductionOnly 14 pages are availabe for public view
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Abstract
P.aeruginosa is an opportunistic Gram-negative bacterium. It is a multidrug-resistant pathogen with considerable medical importance. The World health organization lists it as a priority pathogen that requires new antibiotics. P.aeruginosa has many virulence factors including biofilm formation, antibiotic resistance, adherence factors, and toxin secretions. effector proteins are translocated by many pathogenic bacteria into host cells through a type three secreting system (T3SS) (Cornelis et al., 1997; Galán et al., 1999).
The injectisome (T3SS) is crucial for pathogenicity in many important human pathogens as Shigella, Salmonella, and pathogenic Escherichia coli, killing millions of lives each year (Marshall et al., 2014). Specific effector proteins are injected into host cells in the right order to induce a response beneficial for the bacterium without alerting the host immune system. For successful infection, bacteria must thus tightly control the timing, rate, and substrate specificity of effector translocation by the T3SS.