الفهرس 
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Abstract
The aim of this study was to analyze serum BPA concentrations in order to identify the potential impact of BPA on the hormonal profiles of women with and without PCOS and to discover whether this endocrine disruptor may be an environmental factor in PCOS pathogenesis.
The studied patients included 60 patients classified into: group I (PCOS cases): consisted of 30 apparently healthy volunteers and group II: (control) consisted of 30 patients diagnosed with PCO.
All patients were subjected to the following:
A detailed history administration including the menstrual history ―oligomenorrhea, amenorrhea, …etc‖, history of contraceptives uses ―type and duration of taking‖, medical history of any systemic disease as ―diabetes mellitus, thyroid disease, heart disease, endometrial cancer‖, drug history for any medications ―types, duration, doses‖, family history of any similar condition, history of any investigations for the same condition.
A careful medical examination ”general and local examination
General examinations: included ―vital signs, weight, height, BMI, both breasts. Local examinations: such as local abdominal examination, pelvic examination in the form of inspection, digital PV, bimanual pelvic examination as well as speculum examination.
Laboratory investigations: serum level of the following (in the follicular phase of the menstrual cycle (third day)): Prolactin, Thyroid functions ―TSH‖, LH/FSH ratio, Free testosterone, 17-hydroxy-progesterone, Androstenedione, SHBG ,Serum Bisphenol A level.
The results of this study could be summarized as follow:
There were no statistically significant differences among polycystic ovary syndrome cases and control studied groups regarding age, body mass index, residency and career (P>0.05).
Sex hormone binding globulin was statistically significantly decreased among PCOS cases group than control group, (P<0.05). While TSH, LH / FSH ratio, free testosterone, androstendione and bisphenol A were statistically significantly
Summary
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Increased among PCOS cases group than control group (P<0.05). On the other hand, there were no statistically significant differences among PCOS cases and control studied groups regarding prolactin and 17-OH progesterone (P>0.05).
Most of polycystic ovary syndrome cases group had moderate degree of BPA exposure and moderate degree of hirsutism (50.00%, 33.33%) respectively, while, most of control group had no exposure of BPA and no hirsutism (76.67%, 63.33%) respectively, with a statistically significant difference (P<0.001).
There was no statistically significant Relationship between age, body mass index, residency and career and different degrees of BPA exposure among both studied groups (P>0.05).
There was no statistically significant between different degrees of BPA exposure among control group and sera levels of prolactin, TSH, BPA, LH / FSH ratio, free testosterone, androstendione, 17-OH progesterone and SHBG (P>0.05).