الفهرس 
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Abstract
In this work, we prepared zinc oxide using green synthesis, where for the first time tomato juice was used in preparation, which its important medicinal properties, due to the presence of carotenoids (such as lycopene), polyphenols, and ascorbic acid, which are among Antioxidants and anticarcinogens. This method is considered promising because it is rapid, one-step environmentally friendly, andcost-effective. The application of ZnO NPs for UV protection still faces some challenges due to their white color. Accordingly, the other part of the work came to mix zinc oxide with organic or inorganic safe agents to improve its effectiveness as a sunscreen. Biological minerals such as iron and its oxides (magnetite: Fe3O4) are promising for modulating biomaterials agents. They are nontoxic, biodegradable, and biocompatible. Therefore, the aim and novelty of this work is firstly to prepare ZnO using green synthesis where tomato juice was used as a combustion fuel agent and secondly to solve the challenges inherent in ZnO NPs as an inorganic sunscreen by hybridizing it with a biometallic oxide (Fe3O4) that can protect skin from visible light. The obtained samples were characterized by XRD, FTIR, FESEM, and UV-vis diffuse reflectance techniques. The in vitro sun protection factor (SPF) and antioxidant activity of the prepared samples. The biocompatibility potential was tested on the normal (Human lung fibroblast: WI38) and cancerous (Hepatocellular carcinoma: HEPG-2) cell lines and the antibacterial activity was tested against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. For (ZnO NPs) using Solanum Lycopersicum, XRD show pure structure of the sample, SEM image showed that the ZnO NPs have a quasispherical shape with a size of about 39 ± 12 nm. ZnO NPs showed high potency as sunscreens (in vitro SPF = 16.8) and as mild antioxidant agents. Notably, ZnO NPs enhanced the cytotoxic activity against hepatocellular carcinoma cells and confirmed their antibacterial activity against pathogenic bacteria. One the other hand Bare ZnO NPs and ZnO/Fe3O4 hybrid nanocomposites had pure structures with average particle sizes on a scale below 100 nm. The samples had antibacterial and antioxidant activity as well as the potential for biocompatibility and anticancer activity. The nanocomposite presented good UV absorption and SPF values (SPF = 12.2 to 14) not too far from those of bare ZnO (SPF = 15.4) and achieved extended protection over the UV and visible range. ZnO/Fe3O4 hybrid nanocomposites are colored compounds that can match a desired tanned skin tone and have biophysical properties that make them a promising future as a cosmetic UV protectant.