الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Diabetes is a prevalent health problem in today’s many culturally and economically diverse nations. Nephropathy, retinopathy, and neuropathy are among the many problems that may arise from this condition. Metabolic disruptions caused by insulin resistance or absolute or relative insulin insufficiency are the primary causes of this. Hyperglycemia, dyslipidemia, increased free radicals, and macro and micro vascular complications are all symptoms of this hormone deficit, whether relative or absolute. The metabolic processes of the body, including insulin, glucose, and lipid metabolism, are intricately connected to adropin and other polypeptides. It aids in controlling blood sugar levels and maintains insulin sensitivity in the body. The cellular and molecular mechanisms of DM and DN and its difficulties may be better understood via research on adropin and related compounds. This, in turn, might lead to the development of novel marker for DN in type 2 diabetic patient. The purpose of this study was to compare adropin levels in four groups: group 1: This group will include 20 healthy volunteers to serve as control group. group 2: This group will include 20 adult patient with type 2 diabetes mellitus and normoalbuminuria. group 3: This group will include 20 adult patients with type 2 diabetesmellitus and microalbuminuria. group 4: This group will include 20 adult patients with type 2 diabetes mellitus and macroalbuminuria. The following were administered to both the control group and the patients: Full patient history. Thorough clinical examination: Other standard laboratory tests beside adropin and ACR Abdominopelvic ultrasonography The research did not include patients who were < 18 years old, as well as those who had renal impairment due to conditions other than diabetes mellitus, such as urinary tract infections, obstructions in the urinary system, or being pregnant. Everyone who took part in the research was required to sign an informed consent form. Comparison between healthy control and diabetic group showed lower serum adropin level in diabetic group. Also serum adropin level in diabetic group with macroalbuminuria was significantly lower than diabetic group with microalbumiuria or without albuminuria. Blood glucose level, duration of diabetes, albumin to creatinine ratio in urine, and serum creatinine were in a negative correlation with serum adropin. Increase in one of these parameters was associated with adropin decrease.