الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
It is important when treating chronic diseases to evaluate the hazards of these medications used on the human body and carefully assess the side effects of these medications. Erosive medications that cannot be avoided may be a more worrying cause of erosive tooth wear. Oral medications for children are often in liquid form for ease of swallowing. Unfortunately, many of these medications have high erosive potential. The study aimed to assess the erosive effects of pediatric medicaments on primary teeth enamel, and trying to minimize these effects by application of remineralizing materials. The remineralizing materials used in this study have been proven to be effective in enamel remineralization, but no studies before gathered these syrup medicaments (Probric, Depakine) with Proshield varnish (NaF) and MI varnish (CPP-ACC + Fluoride). Teeth were collected after extraction and kept in saline. Samples were divided into seven groups, with 10 in each group (n=10). The control group was exposed to artificial saliva (neutral pH). Another 3 groups exposed to Probric syrup, one of them to assess the demineralization occurred in enamel surface, second one was treated first with Proshield and the third one was treated with MI varnish. The remaining 3 groups were exposed to Depakine syrup, one of them to assess the demineralization effects of the drug, the second one was treated with Proshield and the third one was treated with MI varnish. The study period was 28 days, then samples were allowed to dry. Scanning is done to reveal surface changes occurred to the enamel surface and to assess how much the pediatric medicaments affected the enamel. As, the SEM would not give quantitative measures for the amount of demineralization or remineralization occurred. So, EDX analysis was done to accurately measure the percentage of elements by weight especially calcium and phosphate percentage. The study showed that, both pediatric medicaments have erosive potential that led to surface changes and decrease in mineral content of the enamel. Both Proshield and MI varnishes have remineralizing effects on enamel and had decreased the effects of these medicaments but with different levels. Proshield varnish proved more remineralization efficacy with both medicaments. The following conclusions were reached in the study : - Both Probric and Depakine syrups have erosive potential on primary teeth enamel. - Proshield varnish was capable of remineralizing initial enamel lesions that were induced by Probric and Depakine syrups - MI varnish was capable of remineralizing initial enamel lesions that were induced by Probric syrup more than that induced by Depakine solution. - Proshield varnish showed better remineralization ability as compared to MI varnish.