الفهرس 
LITERATURE REVIEWOnly 14 pages are availabe for public view
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Abstract
Cardiovascular diseases (CVDs) affect a large portion of the population and are the main cause of death in developed nations, as well as a major contributor to high healthcare expenses. Myocardial infarction (MI) is a serious medical condition that can cause irreversible damage to the heart. Reactive oxygen species (ROS) concentration, inflammatory responses, the production of damage-associated molecular patterns, and the release of numerous cytokines that control immune cell migration towards injury sites are all directly correlated with how much damage MI causes.
Myocardial infarction (MI) management has attracted a lot of scientific attension.So the trend to use cardioprotective products as NaHS and zinc-aspirin complex Zn(ASA)2 has become important and useful. The present study evaluated and compared the cardioprotective effect of NaHS (6.3 mg/kg b.w, i.p., 3 days/week) and Zn(ASA)2 (100 mg/kg b.w, orally, and daily for 21 days), separately or together, on the chemically-induced myocardial infarction rat model by STZ (50mg/ kg b.w, i.p., single dose) and ISO (100 mg/kg b.w, s.c, on day 20 and 21) for 21 consecutive days. Moreover, this study tested the potency of NaHS and Zn(ASA)2 separately or together as antioxidant,anti-inflammatory and anti-apoptotic compounds. Furthermore, the study extends to evaluate any side effects caused by Zn(ASA)2 and NaHS.
The results of the present study showed that the MI group had a significant decrease (P< 0.05–0.001, compared with the control group) in body weight, serum zinc concentration, serum iron concentration, activity of reduced glutathione (GSH), Superoxide dismutase (SOD) and catalase (CAT).
On the other hand, it showed a significant increase (P < 0.05–0.001, compared with the control group) in heart relative weight, serum ASAT, LDH, CK-MB, troponin-T activity, serum TNF-α level, and myocardial MDA level. Additionally, MI group showed a significant downregulation in cardiac BcL-2 expression (P < 0.05) accompanied by a significant upregulation in the BAX expression and caspase 3, 8, 9 levels.
Treatment of MI rats with either NaHS or Zn(ASA)2 separately or in combination significantly increased (P < 0.05–0.001, compared with the MI group) body weight, GSH, CAT, Gpx, SOD and Bcl-2. Additionally, treatment of MI rats with either NaHS or Zn(ASA)2 separately or in combination led to significant decrease(P< 0.05–0.001) in the relative heart weight, serum cardiac enzyme levels of (ASAT, LDH, CK-MB and troponin-T) and anti-inflammatory cytokine TNF-α. This was coupled with a significant decrease in the BAX and caspases level (caspase 3, 8, 9).