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Abstract
Most recent research has thrown new light in understanding the relationship between down syndrome and obesity This study aimed to investigate the effect of different intervention for obesity in Down syndrome (DS) children with hypothyroidism. Thirty nine DS children were divided into three equal groups (thirteen patients each). group A (nutrition intervention) received balanced diet. group B (land exercise) received aerobic exercises, jogging-abdominal, bicycling, and body building using free weights. group C (under water exercise) received exercises, and free swimming, with upper and lower limb exercises). The treatment sessions for land exercises and under water exercise group were conducted for 6 months (3 times/week, and last for 30 minutes) with regular change of diet program every week. Assessment of weight, height, BMI using the center of disease and control prevention CDC BMI for age growth charts