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Abstract
Hepatotoxicity induced by oral co-administration of paracetamol (APAP) (500 mg / kg) and alcohol (5 ml/ kg ) to each rat for two and four weeks .On the other hand, oral administration of whey protein isolate (WPI), alpha- lactalbumin (Ü-LA) and beta-lactoglobulin (Ý-LG) are used as therapeutic agents, in two dose levels (100 and 200 mg/kg) after induction of hepatotoxicity in both two and four weeks ,then liver tissue and blood sample collected. Oral administrated of APAP (500 mg / kg ) and alcohol (5 ml/ kg ) for two and four weeks increase in serum levels of alanine aminotransferase (ALT), and aspartate aminotransferase (AST). While, oral administration of WPI, Ü-LA and Ý-LG after APAP and alcohol resulted in reduction in serum AST and ALT activities , serum tumor necrosis factor- alpha (TNF- Ü) and hepatic lipid peroxidation marker malondialdehyde (MDA),while increase oxidative stress biomarkers (hepatic reduced glutathione (GSH) and superoxide dismutase (SOD)