الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
This study completed a comprehensive survey of the extent of the camel blood parasite, trypanosoma evansi, infection in the northern-west coast of Egypt lasted from November 2014 to October 2015, using blood film examination and RoTat1.2 PCR-based assay. The present study was carried out in the frame of PROCAMED project, supported by the European Union (ENPI-Joint operational programme of the mediterranean basin-IEVP-CT). Historical data of our previous and the present survey have shown that trypanosomiasis in this particular area is constant and not subject to change over time. In addition, the present study has clarified that T. evansi is endemic in this area, and its distribution coincides with the distribution of vectors. During the current study, the antitrypanosomal activity of five medicinal plants (camellia sinensis, thymus vulgaris, mentha longifolia, azadirachta indica, and Saliva officinalis) and four plasma proteins was investigated on T. evansi. Within 60 min of incubation, all the tested plant extracts and plasma proteins showed obvious activity on T. evansi using microtiter plates test (in vitro). Subsequently, these materials were assessed for their in vivo antitrypanosomal activity on T. evansi infection in rats. Blood samples from treated and control rats were subjected to haematological and biochemical analyses