الفهرس 
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Abstract
In rats with induced mammary gland carcinoma, supplementation of pumpkin seed extract may have a beneficial therapeutic effect on mammary gland cancer via improvement in the function of mammary gland and potentiation of the antioxidant status. So experiment were made on 40 rats were divided into four group each group contains ten rats: group 1 (control group) was fed on normal ration and received similar injection (one ml) of saline solution for 8 weeks. group 2 (Cancer group) The rats of this group were injected subcutaneously with 7, 12 DMBA in the mammary region at a dose rate of 7.5mg/kg body weight as described by once a week for four consecutive weeks. group 3 (pumpkin group) the rats of this group were received an aqueous solution of pumpkin seed extract orally by gavage (300 mg/kg.bw) as described by day after day for four weeks. group 4 (treatment group) lasted for 8 weeks. In the first four weeks the rats of this group were injected with DMBA at dose (7.5mg/kg.bw) subcutaneously in mammary region once a week for four weeks to develop cancer, then in the second four weeks rats were received an aqueous solution of pumpkin seed extract orally by gavage (300 mg/kg.bw) day after day for four weeks. At the end of the 8 weeks, All groups of animals were sacrified under diethyl ether anesthesia for making tests. We concluded that supplementation of pumpkin seed extract could decrease Cyclin D1 gene expression and could improve oxidant/and oxidant status so can treat breast cancer.