الفهرس 
Magnesium: Physiology andOnly 14 pages are availabe for public view
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Abstract
Background: The need for bariatric surgery is rapidly increasing and the concept of laparoscopy have made bariatric surgery a cost-effective and efficient way of treating the morbidly obese when other non-surgical options have been unsuccessful. Bariatric surgery is effective in reducing obesity related co -morbidities as well as achieving major long-term weight loss and improvement in quality of life. Laparoscopic approach has emerged as a popular alternative to traditional open abdominal surgery as it combines the benefits of less post-operative pain and ileus and less deterioration of postoperative respiratory functions with subsequent shorter postoperative hospital stay and rapid return to normal activities. However, laparoscopic surgeries are associated with hemodynamic, ventilatory and neuroendocrinal changes which result from the combined effects of pneumoperitoneum, hypercapnia secondary to CO2 absorption, anesthesia technique and patient position. Aim of the Work: This study was performed to evaluate the effect of intravenous magnesium on intra-operative and post-operative narcotic requirements and the incidence of postoperative need for mechanical ventilation in bariatric surgeries. Patients and Methods: This randomized clinical study was conducted on 48 adult patients scheduled for elective laparoscopic gastric sleeve operations under general anesthesia in Ain Shams University Hospitals; after obtaining approval of research ethical committee and patients’ written informed consents, Patients were divided into two equal groups 24 patients per group, both groups received Nalbuphen 0.2 mg/kg in induction & Nalbuphen infusion in the rate of 2 mg/hr for 24 hrs postoperative, group (M) recieved intravenous magnesium sulphate on the dose of 50 mg/ kg in 250 ml of isotonic sodium chloride solution 0.9% after induction & Magnesium sulfate infusion as a total dose of 50 mg/kg given over 24 hrs postoperative. Results: results showed that MAP, VAS and CO2 level were significantly less in Mg group than control group & There were no statistically significant differences between the 2 groups as regard demographic data and heart rate Conclusion: It can be concluded that MgSO4 could be a useful adjuvant to general anesthesia in laparoscopic gastric sleeve surgeries, since this molecule is inexpensive, relatively harmless and enables anesthesiologists to avoid the hypoventilation effect of large doses of opioids that may be used in bariatric patients. Also the biological basis for its anesthesia promoting ant-nociceptive and hypotensive effects is promising. Recommendations: Large scale further studies will definitely help to elucidate its role in the field of anesthesia.