الفهرس 
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Abstract
The current retrospective, case- control, hospital-based study was carried out in the Department of Clinical pathology and Department of Neonatology at Minia University hospitals during the period from June 2016 to January 2017. This study aimed to identify the diagnostic efficacies of nCD64 and serum amyloid A versus CRP as an early markers for the diagnosis of neonatal sepsis.
The current study included the following groups:
group I: included 40 neonates suspected to have sepsis. Their gestational age ranged from (35-40wks.), their weights ranged from (1.4 – 3.5 kg) .They were 26 males and 14 females.
group II included 20 neonates apparently healthy apart from neonatal jaundice with matched gestational age as control group but all had normal results and no illness was subsequently detected.
Blood culture results revealed that false negative culture in 22.5% of cases, gram positive in 47.5% of cases and gram-negative culture in 30 % of cases. Results show a sensitivity of 77.5%, a specificity of 50%; PPV 76% and NPV 53%.
Among the different markers of sepsis, nCD64 was statistically higher in patient group when compared to control group (p– value <0.001). It was also lower in septic neonates who survived than in septic neonates who died (p– value = 0.001).
Neutrophil CD64 expression also showed a significant positive correlation with CRP (P– value = 0.001) and negative correlation with HB (P–value = 0.044), TLC (P – value = 0.001), immature neutrophil (P–value = 0.001), I/M (P–value = 0.041) and I/T (P – value = 0.015). It also showed a sensitivity of 100%, a specificity of 100%, PPV 100% and NPV of 100%
Serum amyloid A was statistically higher in patient group when compared to control group (P – value = 0.001). It didn’t show any significant correlation with studied markers. Serum amyloid A showed a sensitivity of 72.5%, a specificity of 80%, PPV 88% and NPV 59%.
CRP was statistically higher in patient group when compared to control group (P – value < 0.001). CRP showed a sensitivity of 97.5%, a specificity of 75%; PPV 88.6% and NPV 93.7%.
Other markers of sepsis that show significant differences between patient group and control group were platelet, I/M, I/T and immature neutrophil with P – value (= 0.001, 0.001, 0.002 and 0.007 respectively).
Markers of sepsis that didn’t show significant differences between patient group and control group were TLC, absolute neutrophil count, mature neutrophils and ESR.