الفهرس 
Normal growth and developmentOnly 14 pages are availabe for public view
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Abstract
The present study was performed on 40 patients w ith low birthweigth . They were ascertained from
the out patient clinic of the Human Genetic Department, National Research Centre. They were
classified according to their birthw eight and clinical diagnosis into 12 syndromes. They were
all subjected to full history taking, thorough clinical examination and anthropometric measurements
including head circumference , weight and length, pedigree construction, cytogenetic analysis
using G-banding technique and other investigations according to the provisional diagnosis . Our
results showed that cases with VLBW had more developmental anomalies than those with LBW.
Assessment of growth velocity of some of our studied cases showed that cases with VLBW remain
significantly shorter and lighter throughout early childhood such as Seckel syndrome, and don’t
seem to catch up. While LBW patients were prone to an increasing of fat deposition in early
childhood such as Russell Silver syndrome. Cytogenetic studies showed chromosomal abnormalities in
45% of the studied cases with low birthweight. This incidence was higher than that reported in
the literatures. So, we emphasized that chromosomal abnormalities can result in some degree of
prenatal growth deficiency. Our study delineated several predisposing factors to prenatal growth
deficiency in the form of maternal age below 21 and above 26 years, consanguinity , primparity
and low socioeconomic status. The findings of different types of chromosoma l abnormalities and
wide variety of syndromes provide the background for genetic studies of fetuses with IUGR on the
population level. We concluded that clinical, cytogenetic and growth evaluation may allow a
conclusive diagnosis with prop er genetic counselling.