الفهرس 
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Abstract
Background: Cisplatin is a powerful antitumor chemotherapeutic agent that is widely used in the treatment of many cancers but it has many side effects on many organs including salivary glands. Bone marrow is considered to be a rich environment that comprises many types of stem cells of which mesenchymal stem cells are the most studied with potentiality to differentiate into many cell types.
Aim: This study was conducted to evaluate the effect of different routes of administration of BMSCs (Bone marrow mesenchymal stem cells) on parotid glands of rats receiving cisplatin. Materials and Methods: Albino rats were divided into 3 groups: a normal group, a control group which received intraperitoneal injection of cisplatin and an experimental group where rats received cisplatin and then received iron oxide labeled BMSCs by either intravenous or intraparotid routes or both. Animals were sacrificed at periods of 3, 6, 10 and 15 days after cisplatin injection, then histological, ultrastructural and immunohistochemical studies were done.
Results: The experimental stem cell treated group showed better histological appearance and increased PCNA proliferation index when compared to the control. The systemic and combination groups showed better results than the local group. Iron oxide-labeled cells were detected with Prussian blue stain. Conclusion: This study proved that BMSCs can improve cisplatin induced cytotoxicity in parotid glands. Systemic administration showed to have a better effect than local intraparotid administration and comparable effect to combined administration.