الفهرس 
Introductionand Aim of the workOnly 14 pages are availabe for public view
 |  | from | 149 |  |  |
| | | from | 149 | | |
Abstract
Chronic Obstructive Pulmonary Disease (COPD), a common
disease, is characterized by persistent airflow limitation that is usually
progressive and associated with an enhanced chronic inflammatory
response in the airways and the lung to noxious particles or gases.
Exacerbations and co morbidities contribute to the overall severity in
individual patients.
Pulmonary surfactant consists of about 3% of two
hydrophobic lipoproteins (SP-B and SP-C), 3-6% of two hydrophilic
lipoproteins (SP-A and SP-D) and approximately 90% of lipids which
consist of equimolar amounts of saturated and unsaturated
phospholipid species and cholesterol.
SP-D is thought to play an important role in the pathogenesis of
COPD by oxidant production, inflammatory responses in alveolar
macrophages and apoptotic cell clearance.
Within the SP-D gene, the three SNPs Met11Thr, Ala160Thr and
Ser270Thr are of potential functional relevance. Rs721917 is
a missense substitution which leads the replacement in position 11 of
an ancestral methionine by a threonine (Met11Thr). Subjects carrying
TT -genotype (Met/Met) have increased concentrations of SP-D in
plasma, and show multimers, dodecamers, and monomers of subunits,
whereas CC -carriers (Thr/Thr) produce almost exclusively
monomers.
The SNP rs3088308 causes a substitution of nucleotide adenine
(A) in place of a thymidine (T) in the seventh exon of the SFTPD gene
leading to the replacement of serine (Ser) by threonine (Thr) at
position number 270 in the CRD of SP-D protein molecule. Theis residue corresponds to the carbohydrate recognition domain of the
mature protein which binds various pathogens as well as apoptotic
cells.
Rs721917 is associated with increased susceptibility to
tuberculosis, Influenza A virus, infection, allergic rhinitis,COPD, RSV
infection in infants, atopy and blood levels of SP-D.
The current study was carried out at Medical Biochemistry and
Chest diseases & Tuberculosis Departments, Faculty of Medicine,
Menoufia University. The study was carried out on76 subjects.The
patients were attendants of outpatient and inpatients of Chest diseases
and Tuberculosis Department, Menoufia University Hospitals during
the period from April 2014 to April 2015.