الفهرس 
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Abstract
The present study was designed to assess the levels of neurometals ( zinc, copper and magnesium) in the fullterm newborns diagnosed with hypoxic ischemic encephalopathy to study its possible effects on such neonates .
It was conducted on 30 fullterm neonates inside the NICU of El Minia university hospital in the period from January 2014 to May 2015.
They were 9 females and 21 males with gestational age ranging from 37 to 40 weeks. They all had met the designation criteria for perinatal asphyxia.
The control group included 30 healthy neonates 6 females and 24 males of comparable age and sex .
Neonates with pretmaturity, congenital central nervous system malformations, lethal congenital malformations, metabolic encephalopathies, evidence of neonatal sepsis, chromosomal syndromes and neonatal abstinence syndrome due to suspected maternal substance abuse were excluded from the study.
All neonates included in the study were subjected to careful history, complete clinical examination and laboratory investigations include complete blood picture, renal functions test (urea and creatinine), erythrocyte sedimentation rate (ESR), serum zinc, copper and magnesium level.
In the present study there is statistically non significant difference of weight, sex and gestational age between cases and controls.
In addition there is a highly significant increase in serum zinc level , significant increase in serum copper level in cases compared to control. Magnesium shows decreased levels in cases compared to control but it is non statistically significant. Also there is a highly significant increase in ESR , Urea and creatinine in cases compared to controls. There are highly significant lower median platelets counts in cases compared to controls.
In addition there is a highly significant negative correlation between serum zinc and copper levels with Apgar score values at 1 minute . There is a highly significant positive correlation between serum zinc and copper levels with Apgar score values at 5 minute
There is a significant negitive correlation between serum copper level and serum creatinine level.
There is a significant negative correlation between serum magnesium level and serum creatinine level and median platelets count.