الفهرس 
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Abstract
In conclusion Diabetes mellitus type 2 (formerly non insulin dependent diabetes mellitus ;NIDDM or adult-onset diabetes) is a metabolic disorder that is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency.
FASN is the central enzyme in de novo lipogenesis, catalysing the conversion of malonyl CoA into palmitate. Consequences of excess energy intake include hyperinsulinaemia, elevated triacylglycerol, increased or decreased circulating adipokines and others. These outcomes could potentially lead to higher FASN expression and FASN activity, resulting in increased lipogenesis. Thus, FASN expression may play a role in the causal relationship between the metabolic consequences of excess energy intake and increased fat mass.
Seventy five person selected by the history attended to Sohag University Hospital, 25 of them were suffering from diabetes mellitus , 25 with complicated diabetes and 25 control persons.
Fasting blood glucose, HbA1c, lipogram , Serum fatty acid synthase and 24 h protein in urine were done for those cases. Our results showed that :
• There was significant relation between fatty acid synthase levels in complicated DM and hypoglycemic therapy.
• Significant negative correlation was observed between the fatty acid synthase in complicated group and HGA1c.
• Significant positive correlation was observed between fatty acid synthase in uncomplicated group and VLDL.
• Significant positive correlation was observed between fatty acid synthase in complicated group and LDL.
Recommendation:-
1) FASN can be used for diagnostic and prognostic purposes.
2) Patients should understand that treatment is lifelong and that compliance with dietary management is necessary.
3) Our study need to be done over a wider scale of patients.