الفهرس 
AcknowledgmentOnly 14 pages are availabe for public view
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Abstract
During the past several years, it has become increasingly evident that the pharmacological and toxicological actions of drugs may be frequently changed bv alteration in the rate at which they are metabolism and eliminated. {Such changes in the rate of drug metabolism can be clinically important [because they can markedly alter the steady- state plasma level of drugs in atients and thereby alter the intensity and duration of the therapeutic or )xicological response. The liver:body weight ratio of treated mice with lylmethylnitrosamine for three consecutive days was decreased by 19 % and not change with other tested compounds. The results indicate that the icrosomal protein content in the liver of male mice decreased by 13% after satment with diphenylnitrosamine for one hour a single dose and also :reased by 24% after repeated dose treatments for three consecutive days ethyl butyl nitrosamine.
The present study showed that the hepatic content of P-450 was <edly increased after treatment of male mice with dibutylnitrosamine and )ylbutylnitrosamine for one hour as a single dose. On thp other hand, such lent was decreased after diphenyl nitrosamine treatment for one hour reas, the other tested compounds did not change cytochrome P-450 lent after treatments for one hour as a single dose. ;ated dose treatments of male mice with ethylbutylnitrosamine increased content, whereas such content of P450 decreased after treatment with jnyl and rnethylpropylnitrosamine by 34% and 44% respectively at the period.