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Abstract from the previous two chapter we could summarize our results and finding in the following. I. Human part: ; There were no significant effect of the 3 studied drugs on the thyroid function. As regards serum Ca it is only increased with carbamazepine therapy with no changes associated with other drugs. Na valproat was found to be the most drug studied at this thesis to affect serum prolactin level so carbamazepine & vigabatrine are most suitable used in females with low fertility. Vigabatrine was found to give higher records of serotonin serum level so, it is not suitable for patients with previous history of psychiatric disorder. Na valproate is the most to decrease serum norepinephrine level especially in stroked patient so it has the most protective effect on brain cells in epilepsy after stroke.~gabatrine was highest among studied groups to affect serum GABA level which proves that GABA mediation is the main way of action vigabatrine had. II. Experimental part: Na, valproate Was found to have the lowest noreprephine level at different brain areas with or without vascular disorder so, Na, Valproate is the best anti-epileptic of our study in brain protection. -181- ------------ ---- ------~~------- --- --._------- SUMMARY AND CONCLSVlON Na, valproate one the most studied drug to affect 5-Ht cortical level and this establishes its protective role in cortical brain injury while vigabatrine was highest in thalamus and this supports its role in mode disturbance at both epilepsy with or without vascular disorder. Lowest effect on serotonin at all levels was produced by carbamazepine. The study of GABA levels at different brain areas show that brain GABA inhibition is the maimrole of action of vigabatrin as anti-epileptic followed by Na valproate who use GABA as one of its moods of actions as anti-epileptic. Carbamazepine. The least to affect brain GABA at different brain levels. |