الفهرس | Only 14 pages are availabe for public view |
Abstract The traditional function attributed to white adipose tissue as a passive reservoir for energy storage in the form of triglycerides has been changed by results from recent studies, showing that adipose tissue is a highly active metabolic and endocrine organ. It can release many hormones and factors into the blood stream in response to specific extracellular stimuli or changes in metabolic status. These hormones and factors are actively involved in energy homeostasis, insulin secretion and insulin sensitivity. Among these factors is resistin, which was initially identified in 2001 as a novel mRNA induced during adipocyte differentiation but down-regulated by TZDs. Initial studies suggested that resistin mediates insulin resistance by antagonizing insulin action and modulating one or more steps in the insulin-signaling pathway. Resistin had an inhibitory effect on adipose conversion and was therefore speculated to be a feedback regulator of adipogenesis and a signal to restrict adipose tissue formation. So, resistin has been proposed to be the missing link between obesity and diabetes. Exposure to maternal diabetes inutero is associated with metabolic changes that may impact body size, glucose and intermediary metabolism with increased adiposity at birth, as well as increases in fetal insulin. |