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Abstract This study has been carried on 15 normal control and 15 patients with end stage renal failure under maintenance hemodialysis treatment. The age of these patients ranged between 23 - 38 years with a mean of 29.733 + 5.012 years. Their duration of dialysis treatment ranged between 6 - 25 months with a mean of 14.6 + 6,28 months. It was found that 1- Significant hypoxia (92.2 + 10.84) occurred in most of the patients dialyzed with acetate dialysate. This hypoxia was mainly transient with its greatest degree after 45 minutes. 2- Significant leucopenia occurred after 15 minutes of starting dialysis (1960 + 656) and was corrected after the first hour. 3- With acetate dialysate there was significant Co2 dialysance after one hour of starting dialysis (33.6 + 1.51) 4- ultrafiltration in the first two hours of the session prevent the occurrence of hypoxia while significant leucopenia occurred after 15 minutes of ultrafiltration and was corrected after the first hour (Table 2). 150 5- Significant leucocytosis occurred at the end of hemodialysis session. 6- Nasal oxygen administration in the first hour of dialysis prevent the occurrence of hypoxia throughout the dialysis session inspite of the occurrence of leucopenia and Co2 dialysance. 7- Metabolic acidosis was significantly corrected after 45 minutes of dialysis till the end of the session while ultrafiltration session could not correct it but significant acidosis occurred at the end of ultrafiltration session. 8- significant increase of sodium level occurred during and after the hemodialysis session while nonsignificant changes occurred in ultrafiltration session (Table 9). 9- Significant hypokalemia occurred during and after hemodialysis session (Table 8) while non significant hypokalemia during ultrafiltration session (Table 9). 10- Significant increase of serum calcium level occurred dur ing and after hemodialysis sess ion (Table e,) while nonsignificant decrease occurred during ultrafiltration session (Table 9). 11- The heart rate is regular and nonsignificantly increased in all the sessions and the sudden increase in QRS amplitude after hemodialysis might lead to diagnosis of left ventricular hypertrophy. 151 Recommendation : --------------- 1 _ Hypoxia on dialysis should be well investigated and properly treated particularly in patients with chest and heart diseases and so Nasal oxygen administration in the first hour of dialysis is recommended to prevent the occurrence of hypoxia till the end of the dialysis session. 2 _ Also patient with repeated hypoxia during dialysis can be avoided it by using ultrafiltration in first 2 hours of the dialysis session. |