الفهرس | Only 14 pages are availabe for public view |
Abstract Forty renal patients as well as ten healthy volunteers were selected for this study. The selected subjects were classified into the following groups. -Grou I: Control group (comprises 10 volunteers, 5 females and 5 males) -Groan II: 10 patients with end stage renal failure under dialysis (4 females and 6 males). -Grou III: 30 renal patients under conservative treatment (14 females and 16 males). All patients were subjected to a thorough history taking and clinical examination with special stress on: - 0 Etiology and manifestation of renal failure. Duration of disease and duration of dialysis. 0 Manifestations of atherosclerosis and recurrent infection. The following laboratory tests were performed to every subject: 0 Complete blood picture Complete urine analysis. 0 Serum albumin, Serum urea, Serum creatinine and creatinine clearance. 0 Serum glutathione and glutathione reductase. 97 Summary & conclubiu.• Each patient was given an antioxidant therapy composed of vitamin A 30 (5.54mg/day), vitamin C (100mg/day) and vitamin E ( rag/day) for 6 months. The reevaluated and the laboratory investigation were reperformed after treatment. The following were reported in our work: - -Antioxidant activity lutathione as measured by glutathione and g reductase was significantly lower in all renal patients when compared with controls. -Glutathione and glutathione reductase was significantly lower in group 11 when compared with group -Hemoglobin level, creatinine clearance and serum albumin were red with controls. significantly lower in all renal patients when comp -Hemoglobin level, creatinine clearance and serum albumin were significantly lower in group 11 when compared with group 111. was significantly higher in all -Serum creatinine and serum urea renal patients when compared with controls. -Serum creatinine and serum urea was significantly higher in group 11 when compared with group III. -There was significant positive correlation between glutathione and lobin level, serum albumin and creatinine glutathione reductase, hemog clearance. -There was significant negative correlation between glutathione and serum creatinine, urea, and duration of disease, hypertension, infection and proteinuria. 98 !II 441/011.11110 I ’110014 I1111X11 III Summary & conclusion -There was significant positive correlation between glutathione reductaseand hemoglobin level, serum albumin and creatinine clearance. -There was significant negative correlation between glutathione reductase and serum creatinine, urea, and duration of disease, hypertension, infection and proteinuria. Treatment with antioxidant for 6 month has the following effects: - -Significant elevation in glutathione, glutathione reductase and hemoglobin level in group II (dialysis group). -Significant elevation in glutathione, glutathione reductase creatinine clearance serum albumin and hemoglobin in group III (patients under conservative treatment). -Significant reduction in serum creatinine and serum urea in group III. Conclusion: Our study clearly showed the beneficial effect of antioxidant therapy in improving the antioxidant status, reduction of complication and reduction of progression of renal impairment in all patients. |