الفهرس 
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Abstract
This study dealt with the relation between factor VIII related antigen (F VIII RAG) and vascular
tumors.
It was proved that F VIII RAG .Ls synthesized
and localized in ’the endothelial cells, which ,are
the cells of origen of all vascular tumors except
hemangiopericytoma. Accordingly, F VIII RAG could
be used as a specific vascular tumor marker.
This work aimed to asscess F VIII RAG as a
specific vascular tumor marker.
Forty formalin fixed-paraffin embedded specimens
of vascular tumors were collected, recut and stained
by hematoxylin and eosin as well as F VIII RAG using
PAP technique. Histopathological evaluation of these
tumors was done by studying the H & E stained sections.
These tumors were classified into benign lesion (15
cases) and malignant tumors (25 cases).
Benign lesions were classified into juvenile
hemangioma (3 cases), capillary hemangioma (2 cases),
cavernous hemangioma (1 case), pyogenic granuloma
(2 cases), angiokeratoma (2 cases) and angiofibrolipoma
(1 case) as well as 4 cases of lymphangioma
which were capillary (2 cases) and cavernous lymphangioma
(2 cases). Malignant tumors were found to
(82)
be angiosarcoma (11 cases), Kaposi’s sarcoma (6 cases)
and hemangiopericytoma (8 cases). Both Kaposi’s sarcoma
and angiosarcoma cases were graded into 3 grades,
angiomatous (well differentiated), intermediate
(moderatly differentiated) and solid
(undifferentiated).
The evaluation of F VIII RAG staining results
was done as regards positivity and distribution of
the reaction whether focal or diffuse as well as its
intensity which was graded into weak, moderat and
strong. In relation to positivity, all tumors showed
positive staining for F VIII RAG except only one case
of angiosarcoma and all cases of hemangiopericytoma
This ensured the fact that hemangiopericytoma is not
of endothelial cell origen.
Distribution of the reaction was found to be
diffuse in all benign tumors except in capillary buds
of juvenile hemangioma and cases of pyogenic granuloma
which showed focal staining reaction. This may be
due to immature cells of capillary buds of juvenile
hemangioma and rapied growth of pyogenic granuloma.
In relation to malignant tumors it was found that.
as the tumor was more differentiated, the distribution
of the reaction was more diffuse. Also it was found
that the reaction was more diffuse in benign lesions
(86.7%) than in malignant tumors (56%).
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(83)
Compairing the intensity of the reaction in
benign and malignant tumors, it was found that the
reaction was of higher intensity in benign lesions
while it was usually of lower intensity in malignant
tumors. In relation to the intensity in different
grades of malignant tumors it was found that, the
more differentiated the tumor, the stronger tpe intensity
of the reaction.
Thus it could be concluded that F VIII RAG
is not only a specific vascular tumor marker, but
also it is a marker of vascular tumor differentiation.