الفهرس 
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Abstract
It is well known that mercaptotriazole and ammo triazoles in general possess wide pharmaceutical applications such as fungicidal, anti-inflammatory and antibacterial agents. Thus, conjugation of the antimicrobial agent nicotinic acid with thio/ amino triazoles and amino acid residues could afford a new interesting series of compounds with anticipated potent antimicrobial activity. The first part of this investigation deals with the synthesis of some new nicotiuyl thio and N-aminothiotriazole derivatives as shown in schemes (1-5). The starting compounds nicotinyl-4-phenyl-l,2,4-triazole-5-thiol [1] and nicotinyl-4-ammo-l,2,4,triazole-5-thiol [24] were prepared by conventional methods described in literature i.e. by cyclization of the corresponding thiosemi-carbazide with KOH in case of [1] and dithiocarbazales with hydrazine hydrate in case of [24],
Alkylation of triazole [1] with chloroacetic acid in the presence of sodium hydroxide gave the corresponding triazoly! thioacetic acid derivative [2] which was converted into acid chloride [3] on treatment with thionyl chloride. The latter [3] when reacted with ammonia gave the corresponding amide [4]. Acid [2] on fusion with thiosemicarbo-hydrazides underwent cyclocondenstion to give [10].