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Abstract Male erectile dysfunction is a problem and it seems that its incidence is increasing in our d-ays. Although a great progress has occur red in the understanding of the physiology of erection, diagnosis of impotence and its line of therapy but still this problem needs fin-Iiier research to establish specific lines without complications. Papaverine either alone or wiLh phentolamine are commonly used for diagnosis and irealmeni of impotence but uui \vi(honi compiications. Priapism and fibrosis of the caveiiioi-is lissue aie some of these complications (Virag et al., 1982). Piostai’.landin El proved to be more safer than papaverine in these purposes but it is an invasive techniques (Stackl et al., •^ .<: Allia and Al-Ghoneimi, 1992). I-ocallv aj-’i’ilied vasodilalois if proved to give erection inni^ 01 less similar in tlie i n j eclat-lie drm.’.s wili be more convenient and easily used by tlie palicnl (Cavallim, 1991). Niti-oglyceiiiie is ra[)idly absorbed after topical application .md acts as a vasodilator drug through being similar to nitric oxide v.hich is an endothelium-derived relaxiny, factor. This |