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Abstract Schizophrenia is a progressive and chronic brain disorder that if detected early may be treated in a rigorous manner so that the severe consequences of its chronicity are attenuated. Thus, the search for vulnerability markers, that are sensitive to early biological changes caused by the development of this illness, could have predictive value in the future for the institution of early treatment. The use of cognitive and brain imaging markers as endophenotypes for psychiatric illnesses has become a popular concept in the recent literature. These endophenotypes should be found in unaffected family members at a higher rate than the general population for complex illnesses. 1) Theoretical part: Review of literature: The review of literature is consisted of four chapters: Chapter 1: In this chapter Cognitive dysfunctions in Schizophrenia were covered. Chapter 2: Here we reviewed different brain MRI finding in schizophrenia. Chapter 3: In this part, we reviewed a brief hint on cognitive dysfunctions as endophenotypes for schizophrenia. Chapter 4: In this chapter, we have mentioned neuroradiological variables in nonpsychotic relatives of Schizophrenic patients |