الفهرس 
Introduction & Aim of EssayOnly 14 pages are availabe for public view
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Abstract
Introduction: SLE affects women frequently during the childbearing period. A pregnancy should be allowed only, especially if there are no obvious medical circumstances that could impinge on pregnancy. Every pregnancy in a patient with SLE should be regarded as a high-risk pregnancy, and requires intensive monitoring and immediate treatment of clinical problems. Appropriate pre-conceptional diagnostic procedures are mandatory, especially if problems in earlier pregnancies have occurred. Specific major risk factors for an unfavorable outcome such as aPLs or nephritic syndrome, and contraindications such as severe organ dysfunction, such as cardiopulmonary or renal insufficiency, or PH should be determined prior to conception whenever possible. After conception, obstetricianal and rheumatological visits should be scheduled every 4 weeks until delivery and at least one visit 4 weeks thereafter. Women with active lupus prior to pregnancy more frequently experience a flare of the lupus during pregnancy. Lupus flares can occur at any time during pregnancy, as well as in the several months following delivery. There is a clear impact of LN on outcome of pregnancy and vice versa. If there is a risk for CHB, fetal ECHO should be performed every 1-2 weeks between the 16th -28th week of pregnancy. Pathological serological tests (e.g. aPLs) should be repeated during pregnancy as they can be only temporary. In patients with positive aPL-antibodies, the combination of heparin with aspirin appears to reduce pregnancy loss significantly. Among the DMARDs, antimalarials have the safest records, AZA can be given if required to control the underlying disease. Prednisolone is safe in pregnancy, although if patients are on chronic steroids, stress-dose steroids should be given at delivery. IVIg is effective and safe as no adverse reactions were observed; pregnancy was led without fetal complications. MTX, CYC, MMF and LEF are teratogenic. At present, from the few studies reported, there is no evidence that TNF-α antagonist are linked to embryotoxicity, teratogenicity or increased pregnancy loss. Aim of work: The aim of this essay is review systemic lupus erythematosus and pregnancy Conclusions: SLE female patient should not allow getting pregnant unless she should be controlled for at least 6 months. Her pregnancy should be considered as a high risk one which should be closely followed up by both rheumatologist and high risk obstetrician. A neonatologist should be recruited for delivery team.