الفهرس | Only 14 pages are availabe for public view |
Abstract Three major human diseases, malaria, sleeping sickness and leishmaniasis, are caused by protozoan parasites that are transmitted by blood-sucking insects. Current control measures which involve treating infected patients chemotherapeutically and inhibiting transmission by reducing vector population using insecticides, proved impractical and even harmful to the environment. Understanding the molecular aspects of vector-transmitted protozoa is crucial to design ways to interrupt transmission and to develop rational genetic control strategies. ♦ Aim of Work: - 1- The life cycle of insect-transmitted haemo-protozoa (update). 2- Parasite molecules expressed inside the invertebrate vectors. 3- Significance of parasite molecules in transmission. 4- A brief reference to the possible internal defense armory of insect vectors. ♦ Conclusion: - Presently, in human haemo-protozoan parasites, much more is known about the vertebrate stages than the insect stages. This could be due to , in part, to easier access to the blood stages and perhaps because the vertebrate stages are directly related to the diseased state. Research on molecular aspect of insect stages and the rapid progress in genomics might accelerate the identification of parasite molecules pertinent to vector competence which is crucial to advance in the key areas, such as the identification of new drug and insecticide targets and developing rational anti-parasite strategies as vaccine candidates (including transmission-blocking vaccine) and production of transgenic arthropods refractory to infections. |