الفهرس 
Diabetes MellitusOnly 14 pages are availabe for public view
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Abstract
Aim: to evaluate the central nervous system affection in patients with diabetes mellitus.Subjects & Methods: Eight Egyptian diabetic patients and twenty control individuals were tested by VEPs, BAEPs, SEPs, MEPs, EEG, brain MRI, MRI diffusion and MRI spectroscopy (MRS). The patients were classified into subgroups according to type of DM, duration of DM, level of HbA1c and microangiopathy. Results: There were statistically non-significant differences of EEG changes. SEPs showed a statistically significant increase of mean N9, N13 N22, N9-N13 and N13-N22 interpeak latencies. MEPs showed a statistically significant increase of mean cervical, lumbar, cortical latencies and CMCT. BAEPs showed a statistically significant increase of mean wave I, II, III, IV, V, III-V interpeak, I-V interpeak latencies and I/V amplitude ratio in both ears and mean wave I-III interpeak latency in the left ears. VEPs showed a statistically significant increase of mean P100 latency in both eyes. Brain MRI showed a statistically significant increase of silent ischemic lesions (focal and multiple) in DM type 2 than DM type 1. MRI diffusion showed a statistically significant decrease of parietal and basal ganglia (BG) ADC values. MRS showed a statistically significant increase of mean occipital, parietal and BG NAA/Cr, parietal and basal ganglia Myo/Cr and BG Cho/Cr ratios. There were a statistically significant positive correlation between SEPs, MEPs, BAEPs, VEPs, MRI diffusion and duration of DM; and between BG Cho/Cr ratio and level of HBA1c. We conclude that the central effects of DM are related to duration rather than metabolic control.