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العنوان
New trends in genetics of schizophrenia
الناشر
Mohammed Ahmad Awad El-Wasify ,
المؤلف
El-Wasify , Mohammed Ahmad Awad
هيئة الاعداد
باحث / محمد أحمد عوض الوصيفى
مشرف / زينب أبو الفتوح جمعه
مشرف / محمد فريد أبو الهدى
مشرف / هالة أحمد البرعي
الموضوع
Schizophrenia Classical genetics Overview Schizophrenia Psychopharmaco genetics Overview
تاريخ النشر
2008 .
عدد الصفحات
186 p.:
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب النفسي والصحة العقلية
تاريخ الإجازة
01/01/2008
مكان الإجازة
جامعة المنصورة - كلية الطب - Psychiatry
الفهرس
Only 14 pages are availabe for public view

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Abstract

Schizophrenia is a common, severe and disabling disorder that in a majority of instances requires long-term medical and social care. The population incidence is 0.17-0.57 per 1000. The point prevalence is 2.4-6.7 per 1000 reflecting the typical chronic course. The lifetime morbid risk in the general population is close to 1 percent. Its aetiology remains unknown, although both genetic and environmental risk factors are known to be involved. Its pathophysiology is also largely obscure, and consequently the available treatment can alleviate symptoms but not cure the disease. Genetic factors are crucial in determining susceptibility to schizophrenia. This essay entails the discussion of the new trends in genetics of schizophrenia. The research design is categorized into four main parts: First part includes; classical genetics of schizophrenia. Second part includes: molecular genetics of schizophrenia. Third part includes; pharmacogenetics of schizophrenia. Fourth part includes; various issues concerning psychiatric genetics Till now, no susceptibility gene for schizophrenia has been detected consistently, though a large number of genes have been speculated to be associated with the disorder. Identifying the genes that predispose to schizophrenia face formidable challenges arising from both genetic and phenotypic complexity. Compelling advances in pharmacogenetics and drug metabolism are paving the way for personalized medicine Gene therapy for schizophrenia may a future research topic rather than a current one. Psychiatric genetics in the next 20 years will achieve breakthroughs previously unattaina.