الفهرس 
Anatomy of human prostate
Material and methodOnly 14 pages are availabe for public view
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Abstract
The present study was undertaken to study the effects of hyperprolactinaemia induced by metoclopramide on the prostate of prepubertal and adult rats. Fifty newborn male were used in this study. They were divided into:Group of animals (15 rats): was treated with intraperitoneal injection of 2.2 mg/kg b.w. of metoclopramide for two weeks from postnatal day 22 to 36. The animals were sacrificed at: postnatal day 36 (5 rats), postnatal day 60 (5 rats) and postnatal day 90 (5 rats).Group of animals (10 rats): they were left until postnatal 120 and they were treated with intraperitoneal injection of 2.2 mg/ kg b.w. of meloctopramide then, either sacrificed immediately (5 rats) or after two months (5 rats).Control group: was treated with intraperitoneal injection of saline and used as placebo.Induction of hyperprolactinaemia in prepubertal rats results in histopathological changes in adult rat prostate. These changes include: atypical prostatic hyperplasia, altered secretory functions, inflammatory cellular infiltration of the stroma and marked stromal expansion. The stromal expansion resembles BPH seen in humans. While induction of hyperprolactineamia in adult rats results in the same histopathological changes as in the treated prepubertal groups but the fibromuscular stroma is much less affected. The most serious structural change is the atypical prostatic hyperplasia which is a precursor of prostatic cancer. According to the results of the current work we recorded that, antiemetic drugs (Primpiran) must be given cautiously both in prepubertal and adult individuals. This is due to the marked proliferative changes that might be considered precancerous changes.