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Abstract
The current study was undertaken to investigate the role of haemolysin transport system in efflux of antimicrobials and biocides and
the possible use of efflux inhibitors in combination with such agents.
Escherichia coli is the most common causative agent of urinary
tract infection. Escherichia coli was isolated from patients with clinically
diagnosed urinary tract infection in a rate of 74.2%, and 22.5% of the
isolates were found to be haemolytic. Twelve isolates produced high
titres of haemolysin, among which isolate No. 14 was the most
haemolytic.
The susceptibility profile of the haemolytic isolates to some
antimicrobial agents used in UTI therapy and representatives of different
drug groups was performed. The isolates showed complete resistance to
erythromycin, azithromycin and chloramphenicol. Susceptibility rates of
90%, 65% and 55% were found for gentamicin, polymyxin and
streptomycin, respectively. Susceptibility rates of 40% was found to the
tested fluoroquinolones (ciprofloxacin, norfloxacin and ofloxacin) and
of 20% for each of tetracycline, cefotaxime and cefoperazone.