الفهرس | Only 14 pages are availabe for public view |
Abstract The current study was undertaken to investigate the role of haemolysin transport system in efflux of antimicrobials and biocides and the possible use of efflux inhibitors in combination with such agents. Escherichia coli is the most common causative agent of urinary tract infection. Escherichia coli was isolated from patients with clinically diagnosed urinary tract infection in a rate of 74.2%, and 22.5% of the isolates were found to be haemolytic. Twelve isolates produced high titres of haemolysin, among which isolate No. 14 was the most haemolytic. The susceptibility profile of the haemolytic isolates to some antimicrobial agents used in UTI therapy and representatives of different drug groups was performed. The isolates showed complete resistance to erythromycin, azithromycin and chloramphenicol. Susceptibility rates of 90%, 65% and 55% were found for gentamicin, polymyxin and streptomycin, respectively. Susceptibility rates of 40% was found to the tested fluoroquinolones (ciprofloxacin, norfloxacin and ofloxacin) and of 20% for each of tetracycline, cefotaxime and cefoperazone. |