الفهرس | Only 14 pages are availabe for public view |
Abstract Accurate assessment of post-transplant kidney functions is mandatory for early recognition of rejection and renal drugs toxicity. Many low molecular weight proteins and urinary enzymes as serum cystatin C, urinary GST and urinary NAG are proved to have better diagnostic accuracy and sensitivity for assessment of renal functions. This work was planned aiming to evaluate serum cystatin C as a novel non-invasive laboratory parameter reflecting variation in GFR among kidney transplant recipients, optimize its use in evaluation and follow up of such patients and determine the usefulness of urinary proteins, GST and NAG as markers of renal functions in those patients. This study was conducted on 15 patients with end stage renal disease undergoing renal transplantation in Mansoura urology and Nephrology during the period of March 2006 to June 2007. They are followed up for one year at intervals of one day, one week, one month, six months and one year after transplantation. It was reported that serum creatinine is a more specific in detection of impaired kidney functions one day and one month after transplantation and serum cystatin C is more specific for detection of impaired creatinine clearance one week, six months and one year after transplantation We concluded that serum creatinine is still a good marker to assess th evolution of posttransplant kidney function during the first month after transplantation, serum cystatin C is a reliable endogenous marker of renal function six months and one year after transplantation and both urinary NAG and GST are good markers of tubular function and better correlated with urinary proteins. |