الفهرس 
LIST OF CONTENTS
II-ACUTE LYMPHOBLASTIC LEUKEMIAOnly 14 pages are availabe for public view
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Abstract
Intercellular adhesion molecule-1 (ICAM-1 is a membrane glycoprotein belonging to the immunoglobulin superfamily, present on the surface of variety of cells, such as lymphocytes and endothelial cells, with an important role as an adhesion molecule in cell-cell interaction. ICAM-1 participates as an accessory molecule in the immune recognition; it also provides important costimulatory signals in lymphocyte activation and participates in lymphocyte endothelial cell translocations required for lymphocyte traffic and lymphocyte migration to the tissues. The aim of this study is to assess serum levels of ICAM-1 and its expression in ALL patients at Children Hospital in Mansoura to correlate these levels with other known prognostic factors and patients outcome. This study comprised 40 patients with newly diagnosed ALL and 20 healthy volunteers with matched age and sex were taken as control. ALL patients received treatment and were followed up. In the outpatient department and observed over 18 months. ALL patients and healthy controls were subjected to some laboratory investigations as CBC, serum LDH, serum B2MG and serum ICAM-1 level. This study showed that sICAM-1 level was significantly elevated in the ALL patients compared to control group. Also there was a highly significant increase in sICAM-1 at diagnosis than at remission. There is a positive significant correlation between SOD activity& sICAM-1 level at diagnosis. There was a significant increase in B2MG level in ALL patients (at diagnosis) compared to control group.