الفهرس 
INTRODUCTION AND AIM OF THE WORKOnly 14 pages are availabe for public view
 |  | from | 209 |  |  |
| | | from | 209 | | |
Abstract
The neurochemical basis of the schizophrenia plays a significantrole as the symptoms of the disease can be exacerbated or amelioratedby the administration of relatively simple chemical compounds andthese chemicals have been suggested to interactions with specific neurotransmitter mechanisms. Brain ftmctions can be assessed indirectly by examining peripheral body fluids and tissues. More recently, neurotransmitter mechanisms have been studied directly in post-mortem brain tissue from schizophrenic or in vivo using neuro-imaging techniques. The hypothalamus is the area of the brain most closely linked to fluid and electrolyte balance. The proposed location for the internal osmostat that controls serum osmolarity is the lamma terminalis at the anterior border of the third ventricle. Drinking behavior appears to be mediated by the lateral hypothalamus. Antidiuretic hormone (ADH) is synthesized m the supra-optic nucleus of the hypothalamus and it projects to cortex and brain stem and could therefore play a role in psychiatric illness as well as electrolyte balance (Sklar et al., 1983). Metabolism of neurotransmitters depends on electrolytes and ionic compounds participating m the synapse, therefore, electrolytes are expected to play an important role in stabilizing the internal enviroment and helping the nervous system to respond to external events (Kaplan & Sadock, 1991).