الفهرس 
Introduction
Merkel cell carcinomaOnly 14 pages are availabe for public view
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Abstract
Introduction: Neuroendocrine tumors are a rare tumors that are widely distributed allover the body. They produce several symptoms and syndromes due to overproduction of hormone secretion. They need multimodal approach for treatment. Radical tumor surgery is the only available curative approach; recently, the surgical approach has become more aggressive, including wide resections of metastases together with enucleation of liver metastases and/or hepatic artery embolization with adjuvant chemotherapy or focal hepatic ablation techniques. SS analogs control the symptoms Chemotherapy should be considered for poorly differentiated and progressive GEP tumors and facilitate the preparation of such patients for surgical intervention. Therapy with radionuclides, 131IMIBG for chromaffin cell tumors.Aim of the work:This study aims to discuss the role of chemotherapy and radiotherapy as adjuvant and radical treatment in neuroendocrine malignancies. Suggestions: Clinical suspicion based on the presence of characteristic symptoms and/or syndromes may require assessment of specific or general tumor markers.Genetic screening is necessary if familial syndrome is suspected. The expected efficacy of treatment should be weighed against possible a diverse effects to Maintain the quality of life.