الفهرس 
Introduction and Aim of the Work
Subjects and MethodsOnly 14 pages are availabe for public view
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Abstract
This study comprised 80 diabetic patients: 50 patients with cardiovascular autonomic neuropathy and 30 patients without cardiovascular autonomic neuropathy. 20 apparently healthy persons were included as a control group. The patient were divided into 2 main groups: diabetic patients with cardiovascular autonomic neuropathy and diabetic patients without cardiovascular autonomic neuropathy. Each group subdivided into 2 subgroups according to the type of diabetes ; type 1or type 2. Aim of the work The aim of this study is to evaluate the role of oxidative stress in diabetic patients with cardiovascular autonomic neuropathy, by estimating the level of biochemical markers of both oxidative stress and antioxidative defenses. Results There is highly significant increase in the markers of oxidative stress damage (plasma MDA)with highly significant decrease in the markers of anti oxidative defenses (glutathione peroxidase and superoxide dismutase) in all diabetic patients with CAN either type 1 or type 2 versus diabetic patients without CAN and versus control group (P<0.05). There is non significant differences as regard the markers of both oxidative damage and anti oxidative defenses when comparing type 1 versus type 2 diabetic patients with cardiovascular autonomic neuropathy(P>0.05). Summary and Conclusion
We recommend further studies to assess the levels of the markers of oxidative stress before and after the good glycemic control. We recommend studying the effect of the antioxidative therapies in the prevention and management of cardiovascular autonomic neuropathy and other diabetic complications. We recommend further studies for evaluating the levels of the oxidative stress markers in relation to other diabetic complications.