الفهرس | Only 14 pages are availabe for public view |
Abstract Hepatitis E virus is the major causative pathogen of enterically transmitted nonA, nonB hepatitis. HEV is a serious viral infection that occasionally cause large epidemics in developing countries. The living in rural area are exposed to high risk of HEV infection compared to urban population, whereas the presence of antiHEVIgG was significantly associated with consumption of common village water, oral therapy for schistosomiasis, and the high population density contributed to maintain this infection. The diagnosis of HEV infection is carried out routainly by serological assay for the detection of viral antibodies using Enzyme Linked Immunosorbent Assay (ELISA), which is sensitive and specific in detection of IgG and IgM antibodies to hepatitis E virus. The results for IgG antiHEV were positive in 15 (34.1%) of 44 with hepatitis A virus(HAVIgM), 12 (30%) of 40 with hepatitis B virus(HBsAg & HBeAg), 26 (40%) of 65 with hepatitis C virus(HCVIgG), 5 (27.7%) of 18 with pastinfection with HBsAb, and 2 (7.1%) of 28 with nonA, nonB, nonC hepatitis. The results for IgM antiHEV were positive in 3 (3.3%) of 92 samples, as HEVIgM was positive in 2 (20%) of 10 with hepatitis A virus (HAVIgM) and in 1 (5.3%) of 19 with hepatitis B virus. On the light of the results in this study, there is a positive relationship between liver function levels, Blood picture count and infection with hepatitis E virus. |