الفهرس 
Ocular Bioavailability of Enrofloxacin from CertainOphthalmic Preparations in Rabbits Eyes
Formulation and Stability Study of NaproxenOnly 14 pages are availabe for public view
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Abstract
It is assumed that drugs administered topically to the eye are rapidly absorbed and available at a desirable site in the globe of the eye to exert their therapeutic effect. The main objectives in this investigation were; to evaluate some ocular formulations that may possibly used in treatment of certain eye diseases. In this thesis, two drugs were selected; the first drug was Enrofloxacin (An antibacterial agent) and the second drug was Naproxen (An antiinflammatory agent). The work in this thesis includes, the preparation of inclusion complexes of enrofloxacin with betacyclodextrin and hydroxypropylatedbetacyclodextrin. And then, formulate enrofloxacin in different ophthalmic ointments (water soluble base, absorption base, and emulsion base). and gels (sodium carboxymethylcellulose and sodium alginate). Also, to investigate the release characteristics, stability and ocular bioavailability of enrofloxacin from ophthalmic ointments and gels. Also, the effect of the drug on healing time of inflamed rabbits eyes was studied. Also the work in this thesis includes, the formulation of naproxen in different ophthalmic preparations; DROPs, gels, and ocular inserts. And then, investigate the release characteristics and stability of naproxen from ophthalmic preparations. The obtained results revealed that, Enrofloxacin can be formulated in these bases. Also, the drug solubility, the rate of drug release, the drug stability and the total bioavailability of the drug in different tissues of rabbit?s eye improved by complexation with the selected types of CyDs. After treatment of inflamed rabbits eyes with formulation containing the drug, the ulcers were healed and the denuded layers were completely regenerated and the eye tissues become nearly normal. Also, the obtained results revealed that, Naproxen can be formulated in different ophthalmic preparations; DROPs, gels, and ocular inserts using different bases like; methylcellulose, sodium carboxymethylcellulose, hydroxypropyl methylcellulose. from the obtained results, the drug released from eye DROPs was higher than that from ocular inserts and followed by gels. The drug showed a great stability up to 6 months of storage at different temperatures using sodium carboxymethylcellulose, hydroxypropyl methylcellulose polymers.