الفهرس | Only 14 pages are availabe for public view |
Abstract Viral infections may induce an acquired form of immunodefeciency, generally lasting a few weeks. In the more severe form such as HIV infection, the immunodefecincy is permanent. Programmed death of Tcells represents one of the mechanisms by which HIV determines the Tcell functional impairment, finally resulting in the destruction of Tcells. FAS/APO1 (CD95) surface molecule is involved in the process, and its ligation mediates DNA fragmentation. In CD4+ and CD8+ populations obtained from cytomegalovirus seropositive subjects, and cultured in the presence of cytomogalovirus antigen , the expression of Fas increased significantly. This gave the impetus to ascertain whether adysregulation of apoptosis may also be associated with the partial anergy that follows infections with varicella <U+2013> zoster and mumps virus in children. Peripheral blood mononuclear cells (PBMC), were examined for spontenous apoptosis, obtained from thirty children with varicella (16 girls and 14 boys), thirty children with mumps ( 18 boys and 12 girls) and from thirty control children of comparable age and sex were included in the present study. |