الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
This study provided an additional evidences that indomethacin at a high dose level is considered as a hepatotoxic and nephrotoxic agent. The results documented that the changes in both oxidative stress and lysosomal activity could play a part in the mechanisms of the indomethacin-induced hepatic and renal cell injury. Administration of melatonin alone exerted a moderate suppressive effect on the basal tissue rate of oxidative stress in the intact rats. On the other hand, both melatonin and indomethacin exerted similar responses in some analyzed metabolic parameters. Melatonin pretreatment reduced only some of the adverse changes in the indices of cell oxidative injury induced by subsequently administered indomethacin. Present results suggested that the selected low dose of melatonin together with the abilityofindomethacin to inhibit melatonin secretion, and the chosen route of administration might play an impot1ant part intheattenuation of the antioxidative capacity ofmelatonin against high dose of indomethacininduced cytotoxicity. In view of this, the authors recommend the performance of further studies to determine the exact role of the melatonin, as a potent antioxidant, in the protection against indomethacin-induced hepatotoxicity and nephrotoxicity in rats, in terms of dose level and .rout of administration.