الفهرس 
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Abstract
Quality of life as an outcome variable has become an important measure in clinical research. Making a transition from a ?biomedical model? of health to one that incorporates the social aspects of disease, clinicians and researchers dealing with chronic illness now incorporate quality of life measures into clinical practice and research. chronic liver cell failure has shown a significant impact on the well being of patients and contributes to the significant morbidity associated with these conditions. The evaluation of quality of life in chronic liver disease is a crucial outcome measure of all interventions on patients; thus a reliable and valid healthrelated quality of life diseasetargeted measures are needed. One of these measures is the chronic Liver Disease Questionnaire (CLDQ) which is short, easy to administer, produces both a summary score and domain scores, and correlates with the severity of liver disease. We found that the severity of chronic liver disease is associated with advanced age, hepatic encephalopathy, GIT bleeding, bilharziasis, splenomegaly, ascites, elevated serum total bilirubin, low serum albumin, prolonged prothrombin time and worse ChildPugh class. While, gender and serum transaminases are not associated with disease severity. CLDQ consistently and negatively correlated with all dimensions of disease severity such as total serum bilirubin and ChildPugh classification and this reflects CLDQ<U+2019>s usefulness in targeting disease specific aspects of dysfunction in patients with chronic liver disease and highlights the impact of this progressive illness on patients<U+2019> experience and HRQL (Health Related Quality of Life).