الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
This study was conducted to evaluate the possible benefitthat high risk patients for the development of preeclampsia maygain from a new preventive measure; antioxidants.Many studies have shown the role of oxidative stress andoxygen free radicals in the pathogenesis of preeclampsia.Antioxidant level was found to be deficient in patients withpreeclampsia. from that point we started our trial by selection ofhigh-risk patients depending on clinical risk factors andevaluation of the effect of antioxidants supplementation duringthe second half of pregnancy on the occurrence of preeclampsia.Results were compared with a control group that shared almostthe same risk factors but received placebo.The study involved a total 130 high-risk pregnant ladieswith mean gestational age about 20 weeks’ gestation. They wererandomly divided into two, antioxidant and placebo groups.Follow up of patients till delivery revealed a significantreduction in the incidence of occurrence of preeclampsia amongthe group received antioxidant therapy. The severity of thedisease was also affected as there was a significant reduction ofincidence of severe preeclampsia and superimposedpreeclampsia in the group received antioxidants.Comparing the incidence of preeclampsia in both groupsin relation to each risk factor revealed a significant reduction inthe incidence of the disease in high and low risk patients in thegroup that received antioxidants. This inspires the use ofantioxidants as a routine preventive therapy to all pregnant ladies. Also, there were no significant differences in the incidenceof other obstetric complications except that intrauterine growthrestriction showed a higher incidence in the placebo group. Pregnancy outcome was also assessed and results werecompared between both groups. A higher percentage ofstillbirths were noted in the placebo group, but it was not statistically significant.