الفهرس 
Introduction and Aim of the WorkOnly 14 pages are availabe for public view
 |  | from | 136 |  |  |
| | | from | 136 | | |
Abstract
A retrospective analysis was performed on 30 patients with operable breast cancer referred to Clinical Oncology and Nuclear Medicine Department, Mansoura University Hospital, after surgical management during the period from 1993 to 1998. The. aim was the prognostic significance of DNA ploidy of the tumour and S-phase fraction by using DNA flow cytometry from paraffine section containing the tumour of previously treated patients after preparation by Hedly method 1983. Then correlated the ploidy status, DNA index and S-phase fraction values with other clinical data such as tumour size, histologic grading, number of involved lymph nodes, estrogen receptors, DFS and OAS . The peak age incidence of breast cancer was found between 40¬50 years. Post menopausal females were more commonly affected. Patients with a diploid tumours had a longer DFS and OAS than those with an aneuploid tumour. Patients with S-phase fraction value more than 10% had a shorter DFS and OAS, also had a greater number of involved lymph nodes and associated with high rate of recurrence. There was +ve correlation between S-phase fraction and DNA index and number of involved lymph nodes.