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Abstract From the above result we concluded that Elevated levels of circulating ICAM -1 may be produced in liver disease in response to hepatic inflammation but this remains speculation. Serum ICAM-1 closely correlated with activity of the disease more than chronicity. Serum ICAM-1 strongly correlate with the degree of activity (grading) more than i~s correlation with degree of fibrosis ( staging). K _ Serum ICAM-1 concentration may represent, at least in part, hepatcellular damage. In the same time sICAM-1 may be used as a useful non invasive indicator of liver cell damage and, to less extent, to suspect the histological graded inflammatory activity in the liver. |